NP_009010.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
10,494 Da
NCBI Official Full Name
protein tyrosine phosphatase type IVA 3 isoform 2
NCBI Official Synonym Full Names
protein tyrosine phosphatase type IVA, member 3
NCBI Protein Information
protein tyrosine phosphatase type IVA 3; potentially prenylated protein tyrosine phosphatase; protein-tyrosine phosphatase 4a3; protein-tyrosine phosphatase of regenerating liver 3
UniProt Protein Name
Protein tyrosine phosphatase type IVA 3
UniProt Synonym Protein Names
PRL-R; Protein-tyrosine phosphatase 4a3; Protein-tyrosine phosphatase of regenerating liver 3; PRL-3
UniProt Synonym Gene Names
UniProt Entry Name
TP4A3_HUMAN
NCBI Summary for PTP4A3
This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Comments for PTP4A3
PTP4A3: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. Belongs to the protein-tyrosine phosphatase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component: early endosome; plasma membrane
Molecular Function: prenylated protein tyrosine phosphatase activity
Biological Process: endothelial cell migration
Research Articles on PTP4A3
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Products associated with PTP4A3 recombinant protein
Pathways associated with PTP4A3 recombinant protein
Diseases associated with PTP4A3 recombinant protein
Organs/Tissues associated with PTP4A3 recombinant protein
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