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PTPN5 recombinant protein :: Tyrosine-protein phosphatase non-receptor type 5 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS963965
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $795 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $945 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,070 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,180 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,185 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,210 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,715 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,795 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,840 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,285 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tyrosine-protein phosphatase non-receptor type 5 (PTPN5), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Tyrosine-protein phosphatase non-receptor type 5

 Product Synonym Names    Neural-specific protein-tyrosine phosphatase; Striatum-enriched protein-tyrosine phosphatase; STEP
 Product Gene Name   

PTPN5 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS963965 COA    COA PDF
 Sequence Positions    300-555. Partial.
 Sequence    LQAEFFEIPM NFVDPKEYDI PGLVRKNRYK TILPNPHSRV CLTSPDPDDP LSSYINANYI RGYGGEEKVY IATQGPIVST VADFWRMVWQ EHTPIIVMIT NIEEMNEKCT EYWPEEQVAY DGVEITVQKV IHTEDYRLRL ISLKSGTEER GLKHYWFTSW PDQKTPDRAP PLLHLVREVE EAAQQEGPHC APIIVHCSAG IGRTGCFIAT SICCQQLRQE GVVDILKTTC QLRQDRGGMI QTCEQYQFVH HVMSLY
 OMIM    176879
 3D Structure    ModBase 3D Structure for P54829
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of PTPN5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PTPN5 recombinant protein

   May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors.
 Product Categories/Family for PTPN5 recombinant protein    Neuroscience
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 SDS-PAGE of PTPN5 recombinant protein    PTPN5 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for PTPN5. It may not necessarily be applicable to this product.
 NCBI GI #    90652861
 NCBI GeneID    84867
 NCBI Accession #    NP_001035059.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001039970.1 [Other Products]
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 UniProt Primary Accession #    P54829 [Other Products]
 UniProt Secondary Accession #    Q6P1Z2; Q8N2A1; Q8NDP8; B3KXG7; B7Z386; B7ZAF5; D3DQY7 [Other Products]
 UniProt Related Accession #    P54829 [Other Products]
 Molecular Weight    45.4kD
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 NCBI Official Full Name    tyrosine-protein phosphatase non-receptor type 5 isoform b
 NCBI Official Synonym Full Names    protein tyrosine phosphatase, non-receptor type 5
 NCBI Official Symbol    PTPN5 [Similar Products]
 NCBI Official Synonym Symbols   
STEP; PTPSTEP
[Similar Products]
 NCBI Protein Information    tyrosine-protein phosphatase non-receptor type 5
 UniProt Protein Name    Tyrosine-protein phosphatase non-receptor type 5
 UniProt Synonym Protein Names   
Neural-specific protein-tyrosine phosphatase; Striatum-enriched protein-tyrosine phosphatase; STEP
 Protein Family    Tyrosine-protein phosphatase non-receptor
 UniProt Gene Name    PTPN5 [Similar Products]
 UniProt Synonym Gene Names    STEP [Similar Products]
 UniProt Entry Name    PTN5_HUMAN
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 UniProt Comments for PTPN5    STEP: a non-receptor protein-tyrosine phosphatase. STEP (striatum enriched phosphatase) Contains a single phosphatase catalytic domain located at the C-terminus. Two alternatively-spliced messages have been described.

Protein type: Membrane protein, multi-pass; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: axon; cytosol; endoplasmic reticulum membrane; integral to membrane; perikaryon

Molecular Function: glutamate receptor binding; mitogen-activated protein kinase binding; phosphotyrosine binding; protein binding; protein tyrosine phosphatase activity

Biological Process: negative regulation of MAP kinase activity; positive regulation of protein amino acid phosphorylation; positive regulation of protein import into nucleus, translocation; positive regulation of receptor internalization; protein amino acid dephosphorylation; response to amphetamine; response to drug
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Product References and Citations for PTPN5 recombinant protein

   Complete sequencing and characterization of 21,243 full-length human cDNAs.Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.Nat. Genet. 36:40-45(2004) The full-ORF clone resource of the German cDNA consortium.Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.BMC Genomics 8:399-399(2007) Human chromosome 11 DNA sequence and analysis including novel gene identification.Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.Nature 440:497-500(2006)
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 Research Articles on PTPN5    1. Article focuses on the most recent findings on STEP, discuss how STEP expression and activity are maintained during normal cognitive function, and how disruptions in STEP activity contribute to a number of illnesses. [Review]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PTPN5 recombinant proteinPathways associated with PTPN5 recombinant protein
 Reference Product  PubMed Publications
 FYN recombinant protein  >10 publications with PTPN5 and FYN
 MAPK3 recombinant protein  >9 publications with PTPN5 and MAPK3
 MAPK1 recombinant protein  >9 publications with PTPN5 and MAPK1
 MAPK14 recombinant protein  >2 publications with PTPN5 and MAPK14
 Products by Pathway  Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
Diseases associated with PTPN5 recombinant proteinOrgans/Tissues associated with PTPN5 recombinant protein
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >22 publications with PTPN5 and Mental Disorders
 Disease Models, Animal Antibodies  >13 publications with PTPN5 and Disease Models, Animal
 Cognition Disorders Antibodies  >6 publications with PTPN5 and Cognition Disorders
 Movement Disorders Antibodies  >5 publications with PTPN5 and Movement Disorders
 Memory Disorders Antibodies  >4 publications with PTPN5 and Memory Disorders
 Neurobehavioral Manifestations Antibodies  >4 publications with PTPN5 and Neurobehavioral Manifestations
 Status Epilepticus Antibodies  >2 publications with PTPN5 and Status Epilepticus
 Depressive Disorder Antibodies  >1 publications with PTPN5 and Depressive Disorder
 Edema Antibodies  >1 publications with PTPN5 and Edema
 Poisoning Antibodies  >1 publications with PTPN5 and Poisoning
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >63 publications with PTPN5 and Brain
 Eye Antibodies  >2 publications with PTPN5 and Eye
 Embryonic Tissue Antibodies  >1 publications with PTPN5 and Embryonic Tissue
 Kidney Antibodies  >1 publications with PTPN5 and Kidney
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