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| Product Name
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Tyrosine--tRNA ligase, cytoplasmic (Yars), Recombinant Protein
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| Also Known As
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Recombinant Rat Tyrosine--tRNA ligase, cytoplasmic (Yars)
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| Product Synonym Names
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Tyrosine--tRNA ligase, cytoplasmic; EC=6.1.1.1; Tyrosyl-tRNA synthetase; TyrRS
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| Sequence Positions
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1-528
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| Sequence
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MGDAPSPEEK LHLITRNLQE VLGEEKLKEI LKERELKVYW GTATTGKPHV AYFVPMSKIA DFLKAGCEVT ILFADLHAYL DNMKAPWELL ELRTSYYENV IKAMLESIGV PLEKLKFTKG TDYQLSKEYT LDVYRLSSLV TQHDAKKAGA EVVKQVEHPL LSGLLYPGLQ ALDEEYLKVD AQFGGIDQRK IFTFAEKYLP TLGYSKRVHL MNPMVPGLTG SKMSSSEEES KIDLLDRKED VKKKLKKAFC EPGNVENNGV LSFVKHVLFP LKSEFVILRD EKWGGNKTYT IYQELEKDFA AEVVHPGDLK NSVEVALNKL LDPIREKFNT PALKKLASAA YPDPSKQKPT AKGPAKSSEP EEIIPSRLDI RVGKILSVEK HPDADSLYVE KIDVGEAEPR TVVSGLVQFV PKEELQDRLV VVLCNLKPQK MRGVDSQGML LCASVEGVSR QVEPLDPPAG SAPGERVFVQ GYEKGQPDEE LKPKKKVFEK LQADFKISDD CVAQWKQTNF MTKLGFVSCK SLKGGNIS
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| 3D Structure
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ModBase 3D Structure for Q4KM49
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| Host
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E Coli or Yeast or Baculovirus or Mammalian Cell
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| Purity/Purification
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>90%
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| Form/Format
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Liquid containing glycerol; lyophilization may be available upon request.
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| Tag Information
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This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
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| Sterility
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Sterile filter available upon request.
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| Endotoxin
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Low endotoxin available upon request.
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| Species
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Rattus norvegicus (Rat)
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| Preparation and Storage
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Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
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| ISO Certification
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Manufactured in an ISO 9001:2008 Certified Laboratory.
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| Other Notes
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Small volumes of Yars recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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TOP
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| NCBI/Uniprot data below describe general gene information for Yars. It may not necessarily be applicable to this product. |
| NCBI GI #
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411147388
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| NCBI GeneID
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313047
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| NCBI Accession #
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NP_001020867.2
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[Other Products]
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| NCBI GenBank Nucleotide #
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NM_001025696.1
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[Other Products]
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| UniProt Primary Accession #
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Q4KM49
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[Other Products]
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| UniProt Related Accession #
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Q4KM49
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[Other Products]
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| Molecular Weight
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59,115 Da
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TOP
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| NCBI Official Full Name
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tyrosine--tRNA ligase, cytoplasmic
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| NCBI Official Synonym Full Names
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tyrosyl-tRNA synthetase
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| NCBI Official Symbol
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Yars
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[Similar Products]
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| NCBI Protein Information
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tyrosine--tRNA ligase, cytoplasmic; tyrRS; tyrosyl--tRNA ligase; tyrosyl-tRNA synthetase, cytoplasmic
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| UniProt Protein Name
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Tyrosine--tRNA ligase, cytoplasmic
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| UniProt Synonym Protein Names
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Tyrosyl-tRNA synthetase; TyrRS
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| Protein Family
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Tyrosine--tRNA ligase
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| UniProt Gene Name
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Yars
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[Similar Products]
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| UniProt Synonym Gene Names
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TyrRS
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[Similar Products]
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| UniProt Entry Name
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SYYC_RAT
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| UniProt Comments for Yars
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YARS: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr). Defects in YARS are the cause of Charcot-Marie-Tooth disease dominant intermediate type C (CMTDIC). CMTDIC is a form of Charcot-Marie-Tooth disease characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec. Belongs to the class-I aminoacyl-tRNA synthetase family.
Protein type: Ligase; EC 6.1.1.1
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: tyrosine-tRNA ligase activity; ATP binding; isoleucine-tRNA ligase activity; tRNA binding
Biological Process: isoleucyl-tRNA aminoacylation; tyrosyl-tRNA aminoacylation
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TOP
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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TOP
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| Products associated with Yars recombinant protein | Pathways associated with Yars recombinant protein |
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| Diseases associated with Yars recombinant protein | Organs/Tissues associated with Yars recombinant protein |
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TOP
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Recombinant Protein 
