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SNRPA recombinant protein :: U1 small nuclear ribonucleoprotein A Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS717096
SDS-PAGE
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.05 mg  /  $190 +1 FREE 8GB USB
0.1 mg  /  $285 +1 FREE 8GB USB
0.2 mg  /  $460 +1 FREE 8GB USB
0.5 mg  /  $750 +1 FREE 8GB USB
1 mg  /  $1,180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

U1 small nuclear ribonucleoprotein A (SNRPA), Recombinant Protein

 Also Known As   

Recombinant Human U1 small nuclear ribonucleoprotein A

 Product Gene Name   

SNRPA recombinant protein

[Similar Products]
 Matching Pairs    Antibody: SNRPA (MBS7041730)
Standard: U1 small nuclear ribonucleoprotein A (MBS717096)
Comments: Standards are recommendations only. Compatibility of the standards in the user developed application needs to be established and confirmed by the researcher.
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    8-278aa; Partial
 Sequence    PNHTIYINNL NEKIKKDELK KSLYAIFSQF GQILDILVSR SLKMRGQAFV IFKEVSSATN ALRSMQGFPF YDKPMRIQYA KTDSDIIAKM KGTFVERDRK REKRKPKSQE TPATKKAVQG GGATPVVGAV QGPVPGMPPM TQAPRIMHHM PGQPPYMPPP GMIPPPGLAP GQIPPGAMPP QQLMPGQMPP AQPLSENPPN HILFLTNLPE ETNELMLSML FNQFPGFKEV RLVPGRHDIA FVEFDNEVQA GAARDALQGF KITQNNAMKI S
 OMIM    182285
 3D Structure    ModBase 3D Structure for P09012
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 Host    E Coli
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of SNRPA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for SNRPA recombinant protein

   Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds st loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs.
 Product Categories/Family for SNRPA recombinant protein    Transcription
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 SDS-PAGE of SNRPA recombinant protein    SNRPA recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for SNRPA. It may not necessarily be applicable to this product.
 NCBI GI #    4759156
 NCBI GeneID    6626
 NCBI Accession #    NP_004587.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004596.4 [Other Products]
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 UniProt Primary Accession #    P09012 [Other Products]
 UniProt Related Accession #    P09012 [Other Products]
 Molecular Weight    57.4kD
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 NCBI Official Full Name    U1 small nuclear ribonucleoprotein A
 NCBI Official Synonym Full Names    small nuclear ribonucleoprotein polypeptide A
 NCBI Official Symbol    SNRPA [Similar Products]
 NCBI Official Synonym Symbols   
U1A; Mud1; U1-A
[Similar Products]
 NCBI Protein Information    U1 small nuclear ribonucleoprotein A
 UniProt Protein Name    U1 small nuclear ribonucleoprotein A
 Protein Family    U1 small nuclear ribonucleoprotein
 UniProt Gene Name    SNRPA [Similar Products]
 UniProt Synonym Gene Names    U1 snRNP A; U1-A; U1A [Similar Products]
 UniProt Entry Name    SNRPA_HUMAN
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 NCBI Summary for SNRPA    The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation. [provided by RefSeq, Oct 2010]
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 UniProt Comments for SNRPA    Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs.
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Product References and Citations for SNRPA recombinant protein

   Structure, chromosomal localization and evolutionary conservation of the gene encoding human U1 snRNP-specific A protein.Nelissen R.L.H., Sillekens P.T.G., Beijer R.P., Geurts van Kessel A.H.M., van Venrooij W.J.Gene 102:189-196(1991) cDNA cloning of the human U1 snRNA-associated A protein extensive homology between U1 and U2 snRNP-specific proteins.Sillekens P.T.G., Habets W.J., Beijer R.P., van Venrooij W.J.EMBO J. 6:3841-3848(1987) Bienvenut W.V.Submitted (JAN-2004) to UniProtKB The snRNP-free U1A (SF-A) complex(es) identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor.Lutz C.S., Cooke C., O'Connor J.P., Kobayashi R., Alwine J.C.RNA 4:1493-1499(1998) A quantitative atlas of mitotic phosphorylation.Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.Anal. Chem. 81:4493-4501(2009) Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins.Ray D., Kazan H., Chan E.T., Pena Castillo L., Chaudhry S., Talukder S., Blencowe B.J., Morris Q., Hughes T.R.Nat. Biotechnol. 27:667-670(2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions.Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.Science 325:834-840(2009) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.Sci. Signal. 3:RA3-RA3(2010) Initial characterization of the human central proteome.Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.J. Proteomics 96:253-262(2014) Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A.Nagai K., Oubridge C., Jessen T.-H., Li J., Evans P.R.Nature 348:515-520(1990) Crystal structure at 1.92-A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin.Oubridge C., Ito N., Evans P.R., Teo C.-H., Nagai K.Nature 372:432-438(1994) RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins.Hoffman D.W., Query C.C., Golden B.L., White S.W., Keene J.D.Proc. Natl. Acad. Sci. U.S.A. 88:2495-2499(1991) NMR studies of U1 snRNA recognition by the N-terminal RNP domain of the human U1A protein.Howe P.W.A., Nagai K., Neuhaus D., Varani G.EMBO J. 13:3873-3881(1994) Specificity of ribonucleoprotein interaction determined by RNA folding during complex formulation.Allain F.H.-T., Gubser C.C., Howe P.W.A., Nagai K., Neuhaus D., Varani G.Nature 380:646-650(1996) Solution structure of the N-terminal RNP domain of U1A protein the role of C-terminal residues in structure stability and RNA binding.Avis J.M., Allain F.H.-T., Howe P.W.A., Varani G., Nagai K., Neuhaus D.J. Mol. Biol. 257:398-411(1996) Structural basis of the RNA-binding specificity of human U1A protein.Allain F.H.-T., Howe P.W., Neuhaus D., Varani G.EMBO J. 16:5764-5772(1997) Tertiary structure of RBD2 and backbone dynamics of RBD1 and RBD2 of the human U1A protein determined by NMR spectroscopy.Lu J., Hall K.B.Biochemistry 36:10393-10405(1997) Identification of molecular contacts between the U1 A small nuclear ribonucleoprotein and U1 RNA.Jessen T.-H., Oubridge C., Teo C.H., Pritchard C., Nagai K.EMBO J. 10:3447-3456(1991)
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 Research Articles on SNRPA    1. a new mechanism for regulating SMN levels and provides new insight into the roles of U1A in 3' processing of mRNAs.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SNRPA recombinant proteinPathways associated with SNRPA recombinant protein
 Reference Product  PubMed Publications
 U2AF2 recombinant protein  >1 publications with SNRPA and U2AF2
 SNRNP70 recombinant protein  >1 publications with SNRPA and SNRNP70
 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Processing Of Capped Intron-Containing Pre-mRNA Pathway antibodies  Processing Of Capped Intron-Containing Pre-mRNA Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Spliceosome, U1-snRNP Pathway antibodies  Spliceosome, U1-snRNP Pathway Diagram
 Spliceosome, U1-snRNP Pathway antibodies  Spliceosome, U1-snRNP Pathway Diagram
 MRNA Splicing Pathway antibodies  MRNA Splicing Pathway Diagram
 MRNA Splicing - Major Pathway antibodies  MRNA Splicing - Major Pathway Diagram
 MRNA Processing Pathway antibodies  MRNA Processing Pathway Diagram
Diseases associated with SNRPA recombinant proteinOrgans/Tissues associated with SNRPA recombinant protein
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >1 publications with SNRPA and Liver Diseases
 Breast Neoplasms Antibodies  >1 publications with SNRPA and Breast Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with SNRPA and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with SNRPA and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >2 publications with SNRPA and Muscle
 Liver Antibodies  >2 publications with SNRPA and Liver
 Spleen Antibodies  >1 publications with SNRPA and Spleen
 Connective Tissue Antibodies  >1 publications with SNRPA and Connective Tissue
 Kidney Antibodies  >1 publications with SNRPA and Kidney
 Prostate Antibodies  >1 publications with SNRPA and Prostate
 Intestine Antibodies  >1 publications with SNRPA and Intestine
 Lung Antibodies  >1 publications with SNRPA and Lung
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