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ULBP3 recombinant protein :: UL16 Binding Protein 3 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS140770 ULBP3 recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $5,015 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

UL16 Binding Protein 3 (ULBP3), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human UL16 Binding Protein 3

 Product Synonym Names    ULBP3 Human; UL16 Binding Protein 3 Human Recombinant; UL16 Binding Protein 3; Retinoic Acid Early Transcript 1N; ALCAN-Gamma; NKG2DL3; N2DL-3; RAET1N; UL16-Binding Protein 3; NKG2D Ligand 3; N2DL3; ULBP3
 Product Gene Name   

ULBP3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MKHHHHH HASDAH SLWYNFT IIHLPRHGQQ WCEVQSQVDQ KNFLSYDCGS DKVLSMGHLE EQLYATDAWG KQLEMLREVG QRLRLELADT ELEDFTPSGP LTLQVRMSCE CEADGYIRGS WQFSFDGRKF LLFDSNNRKW TVVHAGARRM KEKWEKDSGL TTFFKMVSMR DCKSWLRDFL MHRKKRLEPT APPTMAPG.< /u>
 OMIM    605699
 3D Structure    ModBase 3D Structure for Q9BZM4
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 Host    E Coli
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 Purity/Purification    Purity as determined by densitometric image analysis is greater than 90%.
 Form/Format    ULBP3 was filtered (0.4 um) and lyophilized in 20mM Tris buffer, 50mM NaCl and 0.1% v/v amisoft CS-22, pH 7.5.
Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to add 200 ul of deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. ULBP3 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
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 Preparation and Storage    Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.
 Other Notes    Small volumes of ULBP3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ULBP3 recombinant protein

   Introduction: UL16 Binding Protein 3 (ULBP3) is a ligand for the NKG2D receptor in NK cells. ULBPs activate different signaling pathways resulting in the production of cytokines and chemokines. ULBP3 is a ligand for the KLRK1/NKG2D receptor, along with at least ULBP1 and ULBP2. Binding of ULBPs ligands to KLRK1/NKG2D stimulates calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. ULBP3 has lower affinity for KLRK1/NKG2D compared to ULBP1 and ULBP2 and stimulates weaker signaling responses than does ULBP2 or ULBP1.

Description: ULBP3 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain (Asp30-Gly217) containing 198 amino acids including a 10 aa His tag at N-terminus. The total calculated molecular mass is 23.25kDa.
 Product Categories/Family for ULBP3 recombinant protein    RECOMBINANT & NATURAL PROTEINS
NCBI/Uniprot data below describe general gene information for ULBP3. It may not necessarily be applicable to this product.
 NCBI GI #    13375656
 NCBI GeneID    79465
 NCBI Accession #    NP_078794.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_024518.2 [Other Products]
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 UniProt Primary Accession #    Q9BZM4 [Other Products]
 UniProt Secondary Accession #    Q5VY82; Q8IZX5; Q8TE75 [Other Products]
 UniProt Related Accession #    Q9BZM4 [Other Products]
 Molecular Weight    27,949 Da
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 NCBI Official Full Name    NKG2D ligand 3
 NCBI Official Synonym Full Names    UL16 binding protein 3
 NCBI Official Symbol    ULBP3 [Similar Products]
 NCBI Official Synonym Symbols   
N2DL-3; RAET1N; NKG2DL3
[Similar Products]
 NCBI Protein Information    NKG2D ligand 3
 UniProt Protein Name    NKG2D ligand 3
 UniProt Synonym Protein Names   
ALCAN-gamma; Retinoic acid early transcript 1N
 Protein Family    NKG2D ligand
 UniProt Gene Name    ULBP3 [Similar Products]
 UniProt Synonym Gene Names    N2DL3; RAET1N; N2DL-3; NKG2DL3 [Similar Products]
 UniProt Entry Name    N2DL3_HUMAN
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 UniProt Comments for ULBP3    ULBP3: Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. Has lower affinity for NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does ULBP2 or ULBP1. Belongs to the MHC class I family.

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 6q25

Cellular Component: anchored to plasma membrane; plasma membrane

Molecular Function: antigen binding; natural killer cell lectin-like receptor binding

Biological Process: antigen processing and presentation; natural killer cell activation; natural killer cell mediated cytotoxicity; regulation of immune response
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ULBP3 recombinant proteinDiseases associated with ULBP3 recombinant protein
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >8 publications with ULBP3 and Necrosis
 Lymphatic Diseases Antibodies  >5 publications with ULBP3 and Lymphatic Diseases
 Alopecia Areata Antibodies  >5 publications with ULBP3 and Alopecia Areata
 Nasopharyngeal carcinoma Antibodies  >3 publications with ULBP3 and Nasopharyngeal carcinoma
 Stomach Neoplasms Antibodies  >3 publications with ULBP3 and Stomach Neoplasms
 Adenocarcinoma Antibodies  >3 publications with ULBP3 and Adenocarcinoma
 Inflammation Antibodies  >2 publications with ULBP3 and Inflammation
 Cardiovascular Diseases Antibodies  >2 publications with ULBP3 and Cardiovascular Diseases
 Multiple Myeloma Antibodies  >2 publications with ULBP3 and Multiple Myeloma
 Uterine Cervical Neoplasms Antibodies  >2 publications with ULBP3 and Uterine Cervical Neoplasms
Organs/Tissues associated with ULBP3 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >8 publications with ULBP3 and Bone
 Lung Antibodies  >5 publications with ULBP3 and Lung
 Skin Antibodies  >4 publications with ULBP3 and Skin
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