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UBE2A recombinant protein :: Ubiquitin Conjugating Enzyme E2A Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS144074 UBE2A recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,235 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ubiquitin Conjugating Enzyme E2A (UBE2A), Recombinant Protein

 Also Known As   

Recombinant Human Ubiquitin Conjugating Enzyme E2A

 Product Synonym Names    UBE2A Human; Ubiquitin Conjugating Enzyme E2A Human Recombinant; HHR6A; HR6A; RAD6A; UBC2; UBE2A; EC=6.3.2.19; Ubiquitin-conjugating enzyme E2 A; Ubiquitin-protein ligase A; Ubiquitin carrier protein A; RAD6 homolog A
 Product Gene Name   

UBE2A recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MSTPARRRLM RDFKRLQEDP PAGVSGAPSE NNIMVWNAVI FGPEGTPFED GTFKLTIEFT EEYPNKPPTV RFVSKMFHPN VYADGSICLD ILQNRWSPTY DVSSILTSIQ SLLDEPNPNS PANSQAAQLY QENKREYEKR VSAIVEQSWR DC
 OMIM    300860
 3D Structure    ModBase 3D Structure for P49459
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 Host    E Coli
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 Purity/Purification    Greater than 95% as determined by SDS-PAGE.
 Form/Format    UBE2A Human solution containing 20mM Trsi HCL pH-8, 1mM DTT, 1mM EDTA & 10% glycerol.
Sterile filtered colorless solution.
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 Preparation and Storage    UBE2A Human although stable at 4 degree C for 1 week, should be stored desiccated below -18 degree C. Please prevent freeze thaw cycles.
 Other Notes    Small volumes of UBE2A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for UBE2A recombinant protein

   Description: UBE2A Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 172 amino acids (1-152 a.a.) and having a molecular mass of 19.4 kDa. UBE2A protein is fused to a 20 amino acid His tag at N-terminus and is purified by standard chromatography.

Introduction: The alteration of proteins with ubiquitin is a vital cellular mechanism for targeting atypical or short-lived proteins for degradation. Ubiquitination involves noT less than three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2A is part of the E2 ubiquitin-conjugating enzyme family. UBE2A is necessary for post-replicative DNA damage repair. UBE2A catalyzes the covalent attachment of ubiquitin to other proteins. UBE2A is necessary for postreplication repair of UV-damaged DNA.
 Product Categories/Family for UBE2A recombinant protein    ENZYMES; Enzymes; Ubiquitin Conjugating Enzyme
NCBI/Uniprot data below describe general gene information for UBE2A. It may not necessarily be applicable to this product.
 NCBI GI #    531990811
 NCBI GeneID    7319
 NCBI Accession #    NP_001269090.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001282161.1 [Other Products]
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 UniProt Primary Accession #    P49459 [Other Products]
 UniProt Secondary Accession #    Q4TTG1; Q96FX4; A6NFE9; A6NGR2; A6NMF5; B2R7R9; D3DWI1 [Other Products]
 UniProt Related Accession #    P49459 [Other Products]
 Molecular Weight    8,833 Da
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 NCBI Official Full Name    ubiquitin-conjugating enzyme E2 A isoform 4
 NCBI Official Synonym Full Names    ubiquitin-conjugating enzyme E2A
 NCBI Official Symbol    UBE2A [Similar Products]
 NCBI Official Synonym Symbols   
UBC2; HHR6A; MRXSN; RAD6A; MRXS30
[Similar Products]
 NCBI Protein Information    ubiquitin-conjugating enzyme E2 A; RAD6 homolog A; ubiquitin carrier protein A; ubiquitin-protein ligase A
 UniProt Protein Name    Ubiquitin-conjugating enzyme E2 A
 UniProt Synonym Protein Names   
RAD6 homolog A; HR6A; hHR6A; Ubiquitin carrier protein A; Ubiquitin-protein ligase A
 Protein Family    Ubiquitin-conjugating enzyme
 UniProt Gene Name    UBE2A [Similar Products]
 UniProt Synonym Gene Names    RAD6A; HR6A; hHR6A [Similar Products]
 UniProt Entry Name    UBE2A_HUMAN
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 NCBI Summary for UBE2A    The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
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 UniProt Comments for UBE2A    UBE2A: a ubiquitin-protein ligase, a member of the ubiquitin-conjugating enzyme family. Homologous to the yeast DNA repair gene RAD6. Interacts with RAD18. Required for postreplication repair of UV-damaged DNA.

Protein type: Ubiquitin ligase; EC 6.3.2.19; Ligase; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: Xq24

Cellular Component: XY body; cytoplasm; nuclear chromatin; chromatin; cytosol

Molecular Function: protein binding; small conjugating protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; ATP binding; ligase activity

Biological Process: ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of peptide antigen via MHC class I; protein autoubiquitination; maternal process involved in pregnancy; protein polyubiquitination; postreplication repair; in utero embryonic development; positive regulation of cell proliferation; DNA repair; histone H2A ubiquitination; response to UV

Disease: Mental Retardation, X-linked, Syndromic, Nascimento Type
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 Research Articles on UBE2A    1. HHR6 and hRad18 can monoubiquitinate FANCD2 at lysine 561 in vitro. This activity may represent a novel stress response pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with UBE2A recombinant proteinPathways associated with UBE2A recombinant protein
 Reference Product  PubMed Publications
 UBE2B recombinant protein  >17 publications with UBE2A and UBE2B
 RAD18 recombinant protein  >10 publications with UBE2A and RAD18
 CDK9 recombinant protein  >3 publications with UBE2A and CDK9
 UBE2N recombinant protein  >2 publications with UBE2A and UBE2N
 RNF20 recombinant protein  >2 publications with UBE2A and RNF20
 UBE2V1 recombinant protein  >1 publications with UBE2A and UBE2V1
 RNF40 recombinant protein  >1 publications with UBE2A and RNF40
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
Diseases associated with UBE2A recombinant proteinOrgans/Tissues associated with UBE2A recombinant protein
 Disease Name  Pubmed Publications
 Chromosome Aberrations Antibodies  >4 publications with UBE2A and Chromosome Aberrations
 Brain Diseases Antibodies  >2 publications with UBE2A and Brain Diseases
 Skin Diseases Antibodies  >1 publications with UBE2A and Skin Diseases
 Carcinoma Antibodies  >1 publications with UBE2A and Carcinoma
 Inflammation Antibodies  >1 publications with UBE2A and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with UBE2A and Blood
 Testis Antibodies  >5 publications with UBE2A and Testis
 Brain Antibodies  >5 publications with UBE2A and Brain
 Muscle Antibodies  >2 publications with UBE2A and Muscle
 Heart Antibodies  >2 publications with UBE2A and Heart
 Skin Antibodies  >2 publications with UBE2A and Skin
 Bone Antibodies  >1 publications with UBE2A and Bone
 Bone Marrow Antibodies  >1 publications with UBE2A and Bone Marrow
 Eye Antibodies  >1 publications with UBE2A and Eye
 Intestine Antibodies  >1 publications with UBE2A and Intestine
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