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UBE2L3 recombinant protein :: Ubiquitin-Conjugating Enzyme E2L 3 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142485 UBE2L3 recombinant protein
Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $1,945 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ubiquitin-Conjugating Enzyme E2L 3 (UBE2L3), Recombinant Protein

 Also Known As   

Recombinant Human Ubiquitin-Conjugating Enzyme E2L 3, His Tag

 Product Synonym Names    UBE2L3 Human His; Ubiquitin-Conjugating Enzyme E2L 3 Human Recombinant, His Tag; Ubiquitin-conjugating enzyme E2 L3; EC 6.3.2.19; Ubiquitin-protein ligase L3; Ubiquitin carrier protein L3; UbcH7; E2-F1; L-UBC; UbcM4; UBE2L3 His
 Product Gene Name   

UBE2L3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MHHHHHHAMA ASRRLMKELE EIRKCGMKNF RNIQVDEANL LTWQGLIVPD NPPYDKGAFR IEINFPAEYP FKPPKITFKT KIYHPNIDEK GQVCLPVISA ENWKPATKTD QVIQSLIALV NDPQPEHPLR ADLAEEYSKD RKKFCKNAEE FTKKYGEKRP VD.
 OMIM    603721
 3D Structure    ModBase 3D Structure for P68036
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
 Form/Format    Lyophilized from a 0.2um filtered concentrated (1 mg/ml) solution in 1X PBS and 1mM DTT, pH 7.5.
Sterile Filtered white lyophilized powder.
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 Solubility    It is recommended to reconstitute the lyophilized UBE2L3 in sterile water not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
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 Preparation and Storage    Lyophilized UBE2L3 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution UBE2L3 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of UBE2L3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for UBE2L3 recombinant protein

   Description: Ubiquitin-Conjugating Enzyme E2L 3 Human Recombinant produced in E Coli is an 18.9 kDa protein containing 162 amino acids.The UBE2L3 protein contains 6xHis tag and is purified by proprietary chromatographic techniques.

Introduction: Human Ubquitin Conjugating Enzyme 7 (UbcH7) is a class I enzyme which functions in the stress response and the control of transcription factors. The enzyme is ubiquitously expressed with high levels of expression seen in adult muscle. UbcH7 mediates the selective degradation of short-lived and abnormal proteins and is highly homologous to UbcH5. It has been demonstrated to participate in the ubiquitinylation of p53, c-Fos and NF-?B. UbcH7 is one of two E2s (UbcH5 being the other) with which HECT domain proteins interact with UbcH7 being able to efficiently substitute for UbcH5 in E6-AP-dependent ubiquitinylation.
 Product Categories/Family for UBE2L3 recombinant protein    ENZYMES; Enzymes; Ubiquitin Conjugating Enzyme
NCBI/Uniprot data below describe general gene information for UBE2L3. It may not necessarily be applicable to this product.
 NCBI GI #    373432684
 NCBI GeneID    7332
 NCBI Accession #    NP_001243284.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001256355.1 [Other Products]
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 UniProt Primary Accession #    P68036 [Other Products]
 UniProt Secondary Accession #    P51966; P70653; Q9HAV1; B2R4A7; B4DDG1; B4DSZ4; E7EWS7 [Other Products]
 UniProt Related Accession #    P68036 [Other Products]
 Molecular Weight    24,004 Da
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 NCBI Official Full Name    ubiquitin-conjugating enzyme E2 L3 isoform 4
 NCBI Official Synonym Full Names    ubiquitin-conjugating enzyme E2L 3
 NCBI Official Symbol    UBE2L3 [Similar Products]
 NCBI Official Synonym Symbols   
E2-F1; L-UBC; UBCH7; UbcM4
[Similar Products]
 NCBI Protein Information    ubiquitin-conjugating enzyme E2 L3; ubiquitin carrier protein L3; ubiquitin-conjugating enzyme E2-F1; ubiquitin-conjugating enzyme UBCH7; ubiquitin-protein ligase L3
 UniProt Protein Name    Ubiquitin-conjugating enzyme E2 L3
 UniProt Synonym Protein Names   
L-UBC; UbcH7; Ubiquitin carrier protein L3; Ubiquitin-conjugating enzyme E2-F1; Ubiquitin-protein ligase L3
 Protein Family    Ubiquitin-conjugating enzyme
 UniProt Gene Name    UBE2L3 [Similar Products]
 UniProt Synonym Gene Names    UBCE7; UBCH7 [Similar Products]
 UniProt Entry Name    UB2L3_HUMAN
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 NCBI Summary for UBE2L3    The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]
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 UniProt Comments for UBE2L3    UBE2L3: Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down- regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis. Interacts with PARK2; involved in ubiquitination and degradation of misfolded proteins. Interacts with UBE3A; used by the papilloma virus HPV-16 E6 protein to ubiquitinate p53/TP53. Interacts with CCNB1IP1, CBL, ZAP70, RNF19A, RNF19B and RNF144B. Interacts with ARIH1. Interacts with ARIH2 (via RING-type 1). Interacts with NCOA1; they functionally interact to regulate progesterone receptor transcriptional activity. May interact with NR3C1. Ubiquitous, with highest expression in testis. Belongs to the ubiquitin-conjugating enzyme family.

Protein type: Nuclear receptor co-regulator; Ligase; Ubiquitin ligase; EC 6.3.2.19; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: cytoplasm; nucleus; ubiquitin ligase complex

Molecular Function: protein binding; enzyme binding; ubiquitin protein ligase binding; transcription coactivator activity; ubiquitin-protein ligase activity; ATP binding; ligase activity

Biological Process: ubiquitin-dependent protein catabolic process; cell proliferation; protein polyubiquitination; transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of protein ubiquitination; positive regulation of ubiquitin-protein ligase activity; protein modification process; protein ubiquitination
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 Research Articles on UBE2L3    1. Report role of UBE2L3 genetic variants in confering risk of systemic lupus erythematosus in Chinese population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with UBE2L3 recombinant proteinPathways associated with UBE2L3 recombinant protein
 Reference Product  PubMed Publications
 PARK2 recombinant protein  >9 publications with UBE2L3 and PARK2
 CBL recombinant protein  >9 publications with UBE2L3 and CBL
 UBC recombinant protein  >8 publications with UBE2L3 and UBC
 ARIH1 recombinant protein  >5 publications with UBE2L3 and ARIH1
 SNCA recombinant protein  >2 publications with UBE2L3 and SNCA
 UBE3A recombinant protein  >2 publications with UBE2L3 and UBE3A
 ARIH2 recombinant protein  >1 publications with UBE2L3 and ARIH2
 NEDD4 recombinant protein  >1 publications with UBE2L3 and NEDD4
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 BARD1 Signaling Events Pathway antibodies  BARD1 Signaling Events Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Parkin-Ubiquitin Proteasomal System Pathway antibodies  Parkin-Ubiquitin Proteasomal System Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
 Parkinsons Disease Pathway antibodies  Parkinsons Disease Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
Diseases associated with UBE2L3 recombinant proteinOrgans/Tissues associated with UBE2L3 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >9 publications with UBE2L3 and Nervous System Diseases
 Death Antibodies  >9 publications with UBE2L3 and Death
 Carcinoma Antibodies  >6 publications with UBE2L3 and Carcinoma
 Liver Diseases Antibodies  >4 publications with UBE2L3 and Liver Diseases
 Inflammation Antibodies  >2 publications with UBE2L3 and Inflammation
 Prostatic Diseases Antibodies  >2 publications with UBE2L3 and Prostatic Diseases
 Adenocarcinoma Antibodies  >2 publications with UBE2L3 and Adenocarcinoma
 Heart Diseases Antibodies  >1 publications with UBE2L3 and Heart Diseases
 Lung Neoplasms Antibodies  >1 publications with UBE2L3 and Lung Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1 publications with UBE2L3 and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >10 publications with UBE2L3 and Blood
 Brain Antibodies  >9 publications with UBE2L3 and Brain
 Nerve Antibodies  >4 publications with UBE2L3 and Nerve
 Liver Antibodies  >4 publications with UBE2L3 and Liver
 Lung Antibodies  >3 publications with UBE2L3 and Lung
 Muscle Antibodies  >3 publications with UBE2L3 and Muscle
 Prostate Antibodies  >2 publications with UBE2L3 and Prostate
 Heart Antibodies  >2 publications with UBE2L3 and Heart
 Pancreas Antibodies  >1 publications with UBE2L3 and Pancreas
 Intestine Antibodies  >1 publications with UBE2L3 and Intestine
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