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UBE2L6 recombinant protein :: Ubiquitin Conjugating Enzyme E2L 6 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142488 UBE2L6 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $3,515 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ubiquitin Conjugating Enzyme E2L 6 (UBE2L6), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Ubiquitin Conjugating Enzyme E2L 6

 Product Synonym Names    UBE2L6 Human; Ubiquitin Conjugating Enzyme E2L 6 Human Recombinant; RIG-B; UBCH8; MGC40331; UBE2L6; Ubiquitin/ISG15-conjugating enzyme E2 L6; Ubiquitin-protein ligase L6; Ubiquitin carrier protein L6; Retinoic acid-induced gene B protein
 Product Gene Name   

UBE2L6 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MRGSHHH HHH GMASMTGGQQ MGRDLYDDDD KDRWGS MASM RVVKELEDLQ KKPPPYLRNL SSDDANVLVW HALLLPDQPP YHLKAFNLRI SFPPEYPFKP PMIKFTTKIY HPNVDENGQI CLPIISSENW KPCTKTCQVL EALNVLVNRP NIREPLRMDL ADLLTQNPEL FRKNAEEFTL RFGVDRPS
 OMIM    603890
 3D Structure    ModBase 3D Structure for O14933
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 Host    E Coli
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE.
 Form/Format    The protein contains 20mM Tris pH-8, 0.1mM PMSF, 1mM DTT, and 10% glycerol.
Sterile filtered colorless solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of UBE2L6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for UBE2L6 recombinant protein

   Description: UBE2L6 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 188 amino acids (1-152 a.a.) & having a molecular mass of 21.7 kDa. The UBE2L6 is fused to a 36 amino acid His Tag at N-terminus and purified by standard chromatography techniques.

Introduction: UBE2L6 belongs to the E2 ubiquitin-conjugating enzyme family. UBE2L6 enzyme is very similar in its primary structure to the enzyme encoded by UBE2L3 gene. UBE2L6 catalyzes the covalent attachment of ubiquitin to other proteins. UBE2L6 functions in the e6/e6-ap-induced ubiquitination of p53/tp53.
 Product Categories/Family for UBE2L6 recombinant protein    ENZYMES; Enzymes; Ubiquitin Conjugating Enzyme
NCBI/Uniprot data below describe general gene information for UBE2L6. It may not necessarily be applicable to this product.
 NCBI GI #    4759282
 NCBI GeneID    9246
 NCBI Accession #    NP_004214.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004223.4 [Other Products]
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 UniProt Primary Accession #    O14933 [Other Products]
 UniProt Secondary Accession #    Q8N5D8; Q9UEZ0; A6NDM6; A8MY53 [Other Products]
 UniProt Related Accession #    O14933 [Other Products]
 Molecular Weight    10,086 Da
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 NCBI Official Full Name    ubiquitin/ISG15-conjugating enzyme E2 L6 isoform 1
 NCBI Official Synonym Full Names    ubiquitin-conjugating enzyme E2L 6
 NCBI Official Symbol    UBE2L6 [Similar Products]
 NCBI Official Synonym Symbols   
RIG-B; UBCH8
[Similar Products]
 NCBI Protein Information    ubiquitin/ISG15-conjugating enzyme E2 L6; retinoic acid induced gene B protein; retinoic acid-induced gene B protein; ubiquitin carrier protein L6; ubiquitin-protein ligase L6
 UniProt Protein Name    Ubiquitin/ISG15-conjugating enzyme E2 L6
 UniProt Synonym Protein Names   
Retinoic acid-induced gene B protein; RIG-B; UbcH8; Ubiquitin carrier protein L6; Ubiquitin-protein ligase L6
 Protein Family    Ubiquitin/ISG15-conjugating enzyme
 UniProt Gene Name    UBE2L6 [Similar Products]
 UniProt Synonym Gene Names    UBCH8; RIG-B [Similar Products]
 UniProt Entry Name    UB2L6_HUMAN
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 NCBI Summary for UBE2L6    The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011]
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 UniProt Comments for UBE2L6    UBE2L6: Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3. Belongs to the ubiquitin-conjugating enzyme family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ligase; Ubiquitin conjugating system; EC 6.3.2.19; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 11q12

Cellular Component: cytosol

Molecular Function: protein binding; ISG15 conjugating enzyme activity; ubiquitin-protein ligase activity; ligase activity

Biological Process: ISG15-protein conjugation; modification-dependent protein catabolic process; cytokine and chemokine mediated signaling pathway; innate immune response; protein ubiquitination; protein modification process; negative regulation of interferon type I production
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 Research Articles on UBE2L6    1. study reports that UBCH8 and UBE2G1 and UBE2G2 cooperate with CRL4Cdt2 in promoting the polyubiquitylation and subsequent degradation of p21 and Cdt1, respectively
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with UBE2L6 recombinant proteinPathways associated with UBE2L6 recombinant protein
 Reference Product  PubMed Publications
 ISG15 recombinant protein  >13 publications with UBE2L6 and ISG15
 STAT1 recombinant protein  >1 publications with UBE2L6 and STAT1
 HERC5 recombinant protein  >1 publications with UBE2L6 and HERC5
 DDX58 recombinant protein  >1 publications with UBE2L6 and DDX58
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 ISG15 Antiviral Mechanism Pathway antibodies  ISG15 Antiviral Mechanism Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Negative Regulators Of RIG-I/MDA5 Signaling Pathway antibodies  Negative Regulators Of RIG-I/MDA5 Signaling Pathway Diagram
Diseases associated with UBE2L6 recombinant proteinOrgans/Tissues associated with UBE2L6 recombinant protein
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >3 publications with UBE2L6 and Breast Neoplasms
 Inflammation Antibodies  >3 publications with UBE2L6 and Inflammation
 Influenza, Human Antibodies  >2 publications with UBE2L6 and Influenza, Human
 Poisoning Antibodies  >1 publications with UBE2L6 and Poisoning
 Brain Diseases Antibodies  >1 publications with UBE2L6 and Brain Diseases
 Hypertrophy Antibodies  >1 publications with UBE2L6 and Hypertrophy
 Hyperplasia Antibodies  >1 publications with UBE2L6 and Hyperplasia
 Weight Loss Antibodies  >1 publications with UBE2L6 and Weight Loss
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with UBE2L6 and Blood
 Lung Antibodies  >2 publications with UBE2L6 and Lung
 Bone Antibodies  >1 publications with UBE2L6 and Bone
 Lymph Node Antibodies  >1 publications with UBE2L6 and Lymph Node
 Connective Tissue Antibodies  >1 publications with UBE2L6 and Connective Tissue
 Kidney Antibodies  >1 publications with UBE2L6 and Kidney
 Lymph Antibodies  >1 publications with UBE2L6 and Lymph
 Embryonic Tissue Antibodies  >1 publications with UBE2L6 and Embryonic Tissue
 Intestine Antibodies  >1 publications with UBE2L6 and Intestine
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