NP_001156526.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
41,499 Da
NCBI Official Full Name
urea transporter 1
NCBI Official Synonym Symbols
NCBI Protein Information
urea transporter 1
UniProt Protein Name
Urea transporter 1
UniProt Synonym Protein Names
Solute carrier family 14 member 1; Urea transporter B; UT-B; Urea transporter, erythrocyte
UniProt Synonym Gene Names
UniProt Comments for SLC14A1
Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means ().
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Diseases associated with SLC14A1 recombinant protein
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