O13034.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
59,174 Da
NCBI Official Full Name
V(D)J recombination-activating protein 2
NCBI Official Synonym Full Names
recombination activating gene 2
NCBI Protein Information
V(D)J recombination-activating protein 2
UniProt Protein Name
V(D)J recombination-activating protein 2
UniProt Synonym Gene Names
UniProt Comments for rag2
Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. In the RAG complex, rag2 is not the catalytic component but is required for all known catalytic activities mediated by RAG1. It probably acts as a sensor of chromatin state that recruits the RAG complex to H3K4me3 ().
Research Articles on rag2
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Products associated with rag2 recombinant protein
Pathways associated with rag2 recombinant protein
Organs/Tissues associated with rag2 recombinant protein
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