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JUN recombinant protein :: V-Jun Sarcoma Virus 17 Oncogene Homolog Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2031255 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
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Unit / Price
0.01 mg  /  $190 +1 FREE 8GB USB
0.05 mg  /  $405 +1 FREE 8GB USB
0.1 mg  /  $625 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

V-Jun Sarcoma Virus 17 Oncogene Homolog, Recombinant Protein

 Also Known As   

Recombinant V-Jun Sarcoma Virus 17 Oncogene Homolog (JUN)

 Product Gene Name   

JUN recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with two N-terminal Tags, His-tag and T7-tag, its sequence is listed below.
MGSSHHHHH H SSGLVPRGSH MASMTGGQQM GRGSEF- DDALNASFLP SESGPYGYSN PKILKQSMTL NLADPVGSLK PHLRAKNSDL LTSPDVGLLK LASPELERLI IQSSNGHITT TPTPTQFLCP KNVTDEQEGF AEGFVRALAE LHSQNTLPSV TSAAQPVNGA GMVAPAVASV AGGSGSGGFS ASLHSEPPVY ANLSNFNPGA LSSGGGAPSY GAAGLAFPAQ PQQQQQPPHH LPQQMPVQHP RLQALKEEPQ TVPEMPGETP PLSPIDMESQ ERIKAERKRM RN
 OMIM    165160
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 Host    Host: E Coli
Source: Prokaryotic expression
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 Purity/Purification    >95%
 Form/Format    Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
 Concentration    6.4 (lot specific)
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 Predicted Molecular Mass    30.4kDa
 Accurate Molecular Mass (KD)    34kDa
 Endotoxin    <1.0EU per 1ug (determined by the LAL method)
 Expression System    Prokaryotic expression
 Tag    two N-terminal Tags, His-tag and T7-tag
 Organism Species    Homo sapiens (Human)
 Fragment    Asp11~Asn262
 Usage    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of JUN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for JUN recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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 SDS-Page of JUN recombinant protein    JUN recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for JUN. It may not necessarily be applicable to this product.
 NCBI GI #    119627033
 NCBI GeneID    3725
 NCBI Accession #    EAX06628.1 [Other Products]
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 UniProt Secondary Accession #    Q6FHM7; Q96G93 [Other Products]
 UniProt Related Accession #    P05412 [Other Products]
 Molecular Weight    35,676 Da
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 NCBI Official Full Name    v-jun sarcoma virus 17 oncogene homolog (avian)
 NCBI Official Synonym Full Names    jun proto-oncogene
 NCBI Official Symbol    JUN [Similar Products]
 NCBI Official Synonym Symbols   
AP1; AP-1; c-Jun
[Similar Products]
 NCBI Protein Information    transcription factor AP-1
 UniProt Protein Name    Transcription factor AP-1
 UniProt Synonym Protein Names   
Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39
 Protein Family    Viral jun-transforming protein
 UniProt Gene Name    JUN [Similar Products]
 UniProt Synonym Gene Names    AP1 [Similar Products]
 UniProt Entry Name    JUN_HUMAN
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 NCBI Summary for JUN    This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]
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 UniProt Comments for JUN    Jun: the protooncogene c-Jun is a component of the transcription factor AP-1, which binds and activates transcription at TRE/AP-1 elements. The Jun Kinases (JNKs) binds to the N-terminal region of c-Jun and phosphorylate it in response to extracellular signals including growth factors, cytokines and stress, regulating its transcriptional activity.

Protein type: Transcription factor; Oncoprotein

Chromosomal Location of Human Ortholog: 1p32-p31

Cellular Component: nucleoplasm; nuclear chromosome; transcription factor complex; transcriptional repressor complex; cytosol; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; enzyme binding; DNA binding; double-stranded DNA binding; transcription coactivator activity; transcription factor activity; transcription factor binding

Biological Process: positive regulation of monocyte differentiation; transcription from RNA polymerase II promoter; circadian rhythm; response to cAMP; regulation of cell cycle; positive regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-dependent; stress-activated MAPK cascade; microglial cell activation; response to lipopolysaccharide; SMAD protein nuclear translocation; toll-like receptor 3 signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; negative regulation of cell proliferation; positive regulation of fibroblast proliferation; response to radiation; regulation of transcription factor activity; transforming growth factor beta receptor signaling pathway; positive regulation of neuron apoptosis; negative regulation of protein amino acid autophosphorylation; negative regulation of neuron apoptosis; angiogenesis; toll-like receptor 4 signaling pathway; aging; response to drug; release of cytochrome c from mitochondria; monocyte differentiation; leading edge cell differentiation; axon regeneration; MyD88-independent toll-like receptor signaling pathway; learning; liver development; negative regulation of DNA binding; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; membrane depolarization; cellular response to potassium ion starvation; response to hydrogen peroxide; response to mechanical stimulus; response to cytokine stimulus; toll-like receptor signaling pathway; innate immune response; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; negative regulation of transcription, DNA-dependent; positive regulation of DNA replication
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 Research Articles on JUN    1. In all, these data demonstrate that the AP-1 transcription factor is involved in Chlamydia pneumoniae intracellular development.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with JUN recombinant proteinPathways associated with JUN recombinant protein
 Reference Product  PubMed Publications
 FOS recombinant protein  >8221 publications with JUN and FOS
 MAPK8 recombinant protein  >844 publications with JUN and MAPK8
 SMAD3 recombinant protein  >522 publications with JUN and SMAD3
 ATF2 recombinant protein  >410 publications with JUN and ATF2
 ATF3 recombinant protein  >214 publications with JUN and ATF3
 FOSL2 recombinant protein  >106 publications with JUN and FOSL2
 EP300 recombinant protein  >82 publications with JUN and EP300
 FOSL1 recombinant protein  >22 publications with JUN and FOSL1
 MAPK9 recombinant protein  >12 publications with JUN and MAPK9
 MAPK10 recombinant protein  >5 publications with JUN and MAPK10
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of The AP-1 Family Of Transcription Factors Pathway antibodies  Activation Of The AP-1 Family Of Transcription Factors Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
Diseases associated with JUN recombinant proteinOrgans/Tissues associated with JUN recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >186516 publications with JUN and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >169382 publications with JUN and Cardiovascular Diseases
 Brain Diseases Antibodies  >89101 publications with JUN and Brain Diseases
 Heart Diseases Antibodies  >83711 publications with JUN and Heart Diseases
 Pain Antibodies  >56750 publications with JUN and Pain
 Liver Diseases Antibodies  >44827 publications with JUN and Liver Diseases
 Inflammation Antibodies  >44820 publications with JUN and Inflammation
 Kidney Diseases Antibodies  >38243 publications with JUN and Kidney Diseases
 Hypertension Antibodies  >35813 publications with JUN and Hypertension
 Necrosis Antibodies  >29759 publications with JUN and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >313570 publications with JUN and Blood
 Brain Antibodies  >131546 publications with JUN and Brain
 Heart Antibodies  >103377 publications with JUN and Heart
 Vascular Antibodies  >93024 publications with JUN and Vascular
 Bone Antibodies  >90187 publications with JUN and Bone
 Liver Antibodies  >81458 publications with JUN and Liver
 Muscle Antibodies  >78679 publications with JUN and Muscle
 Lung Antibodies  >62592 publications with JUN and Lung
 Kidney Antibodies  >59864 publications with JUN and Kidney
 Skin Antibodies  >57099 publications with JUN and Skin
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