NP_001170823.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
myc proto-oncogene protein isoform b
NCBI Official Synonym Full Names
myelocytomatosis oncogene
NCBI Official Synonym Symbols
Myc2; Nird; Niard; bHLHe39; AU016757 [Similar Products]
NCBI Protein Information
myc proto-oncogene protein; c-myc proto-oncogene; transcription factor p64
UniProt Protein Name
Myc proto-oncogene protein
UniProt Synonym Protein Names
Proto-oncogene c-Myc; Transcription factor p64
UniProt Entry Name
MYC_MOUSE
NCBI Summary for MYC
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Under conditions of stress, such as high cell densities and methionine deprivation, there is a specific and dramatic increase in the synthesis of the non-AUG initiated protein, suggesting its importance in times of adversity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
UniProt Comments for MYC
Myc: a proto-oncogenic transcription factor that plays a role in cell proliferation, apoptosis and in the development of human tumors. Seems to activate the transcription of growth-related genes.
Protein type: Transcription factor; DNA-binding; Nucleolus; Oncoprotein
Cellular Component: nucleoplasm; nuclear body; protein complex; mitochondrion; axon; cytoplasm; nucleolus; spindle; intracellular; nucleus
Molecular Function: protein dimerization activity; protein binding; DNA binding; sequence-specific DNA binding; protein heterodimerization activity; double-stranded DNA binding; protein complex binding; transcription factor binding; transcription factor activity
Biological Process: positive regulation of catalytic activity; cellular iron ion homeostasis; positive regulation of transcription, DNA-dependent; transcription initiation; regulation of mitotic cell cycle; positive regulation of caspase activity; B cell apoptosis; Wnt receptor signaling pathway through beta-catenin; middle ear morphogenesis; regulation of apoptosis; positive regulation of fibroblast proliferation; positive regulation of mesenchymal cell proliferation; negative regulation of protein binding; cell cycle arrest; inner mitochondrial membrane organization and biogenesis; positive regulation of B cell apoptosis; transcription, DNA-dependent; regulation of telomere maintenance; positive regulation of cell cycle; glucose metabolic process; pyruvate transport; detection of mechanical stimulus involved in sensory perception of sound; DNA damage response, signal transduction resulting in induction of apoptosis; regulation of gene expression; negative regulation of fibroblast proliferation; regulation of oxidative phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of epithelial cell proliferation; transcription from RNA polymerase II promoter; response to alkaloid; lactic acid secretion; negative regulation of transcription from RNA polymerase II promoter; chromosome organization and biogenesis; response to radiation; regulation of transcription, DNA-dependent; amino acid transport; positive regulation of cell proliferation; response to gamma radiation; caspase activation; Wnt receptor signaling pathway; MAPKKK cascade; negative regulation of cell division; negative regulation of monocyte differentiation; chromatin remodeling; cell proliferation; negative regulation of glucose import; pigmentation; ureteric bud branching; skeletal morphogenesis; positive regulation of glycolysis; protein processing; response to DNA damage stimulus; transformation of host cell by virus
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Pathways associated with MYC recombinant protein
Diseases associated with MYC recombinant protein
Organs/Tissues associated with MYC recombinant protein
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