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CRKL recombinant protein :: V-crk Sarcoma Virus CT10 Oncogene Homolog Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS144666 CRKL recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

V-crk Sarcoma Virus CT10 Oncogene Homolog (CRKL), Recombinant Protein

 Also Known As   

Recombinant Human V-crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like

 Product Synonym Names    CRKL Human; V-crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like Human Recombinant; Crk-like protein; CRKL
 Product Gene Name   

CRKL recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MSSARFDSSD RSAWYMGPVS RQEAQTRLQG QRHGMFLVRD SSTCPGDYVL SVSENSRVSH YIINSLPNRR FKIGDQEFDH LPALLEFYKI HYLDTTTLIE PAPRYPSPPM GSVSAPNLPT AEDNLEYVRT LYDFPGNDAE DLPFKKGEIL VIIEKPEEQW WSARNKDGRV GMIPVPYVEK LVRSSPHGKH GNRNSNSYGI PEPAHAYAQP QTTTPLPAVS GSPGAAITPL PSTQNGPVFA KAIQKRVPCA YDKTALALEV GDIVKVTRMN INGQWEGEVN GRKGLFPFTH VKIFDPQNPD ENE
 OMIM    602007
 3D Structure    ModBase 3D Structure for P46109
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 Host    E Coli
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 Purity/Purification    Greater than 90.0% as determined by SDS-PAGE.
 Form/Format    The CRKL solution (1 mg/ml) 20mM Tris-HCl buffer (pH 8.0), 10% glycerol, 2mM DTT and 0.1M NaCl.
Sterile Filtered colorless solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of CRKL recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CRKL recombinant protein

   Description: CRKL Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 323 amino acids (1-303 a.a.) and having a molecular mass of 35.9kDa (Molecular size on SDS-PAGE will appear higher). The CRKL is purified by proprietary chromatographic techniques.

Introduction: Crk-like protein (CRKL) is a protein kinase containing SH2 and SH3 (src homology) domains which activates the RAS and JUN kinase signaling pathways and transforms fibroblasts in a RAS-dependent manner. CRKL is a substitute of the BCR-ABL tyrosine kinase, it also has a role in fibroblast transformation by BCR-ABL, and has oncogenic potential.
 Product Categories/Family for CRKL recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; V-crk Sarcoma Virus CT10
NCBI/Uniprot data below describe general gene information for CRKL. It may not necessarily be applicable to this product.
 NCBI GI #    4885153
 NCBI GeneID    1399
 NCBI Accession #    NP_005198.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005207.3 [Other Products]
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 UniProt Primary Accession #    P46109 [Other Products]
 UniProt Secondary Accession #    A8KA44; D3DX35 [Other Products]
 UniProt Related Accession #    P46109 [Other Products]
 Molecular Weight    33,777 Da
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 NCBI Official Full Name    crk-like protein
 NCBI Official Synonym Full Names    v-crk avian sarcoma virus CT10 oncogene homolog-like
 NCBI Official Symbol    CRKL [Similar Products]
 NCBI Protein Information    crk-like protein
 UniProt Protein Name    Crk-like protein
 Protein Family    Crk-like protein
 UniProt Gene Name    CRKL [Similar Products]
 UniProt Entry Name    CRKL_HUMAN
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 NCBI Summary for CRKL    This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]
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 UniProt Comments for CRKL    CRKL: an oncogenic adaptor protein with an SH2-SH3-SH3 domain structure. Plays a specific role in integrin-induced migration as a downstream mediator of Src. Activates the RAS and Jnk signaling pathways. Transforms fibroblasts in a RAS-dependent fashion. A substrate of BCR-ABL and plays a role in fibroblast transformation by BCR-ABL.

Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: cytosol; endosome

Molecular Function: signal transducer activity; protein binding; SH3/SH2 adaptor activity

Biological Process: anterior/posterior pattern formation; blood vessel development; organ morphogenesis; nerve growth factor receptor signaling pathway; thymus development; activation of MAPKK activity; heart development; Ras protein signal transduction; JNK cascade; parathyroid gland development
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 Research Articles on CRKL    1. Crk1/2 and CrkL are physically linked, functionally complement each other during podocyte foot process spreading, and together are required for developing typical foot process architecture.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CRKL recombinant proteinPathways associated with CRKL recombinant protein
 Reference Product  PubMed Publications
 BCR recombinant protein  >161 publications with CRKL and BCR
 CBL recombinant protein  >70 publications with CRKL and CBL
 ABL1 recombinant protein  >10 publications with CRKL and ABL1
 BCAR1 recombinant protein  >9 publications with CRKL and BCAR1
 PXN recombinant protein  >9 publications with CRKL and PXN
 GAB2 recombinant protein  >7 publications with CRKL and GAB2
 EPOR recombinant protein  >6 publications with CRKL and EPOR
 CBLB recombinant protein  >2 publications with CRKL and CBLB
 MAP4K1 recombinant protein  >1 publications with CRKL and MAP4K1
 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
Diseases associated with CRKL recombinant proteinOrgans/Tissues associated with CRKL recombinant protein
 Disease Name  Pubmed Publications
 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Antibodies  >87 publications with CRKL and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
 Lung Neoplasms Antibodies  >14 publications with CRKL and Lung Neoplasms
 Leukemia, Myeloid, Acute Antibodies  >13 publications with CRKL and Leukemia, Myeloid, Acute
 Disease Models, Animal Antibodies  >12 publications with CRKL and Disease Models, Animal
 Craniofacial Abnormalities Antibodies  >12 publications with CRKL and Craniofacial Abnormalities
 DiGeorge Syndrome Antibodies  >12 publications with CRKL and DiGeorge Syndrome
 Breast Neoplasms Antibodies  >8 publications with CRKL and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >7 publications with CRKL and Neoplasms, Experimental
 Inflammation Antibodies  >6 publications with CRKL and Inflammation
 Skin Diseases Antibodies  >5 publications with CRKL and Skin Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >101 publications with CRKL and Blood
 Bone Antibodies  >26 publications with CRKL and Bone
 Bone Marrow Antibodies  >22 publications with CRKL and Bone Marrow
 Lung Antibodies  >20 publications with CRKL and Lung
 Nerve Antibodies  >20 publications with CRKL and Nerve
 Brain Antibodies  >19 publications with CRKL and Brain
 Heart Antibodies  >13 publications with CRKL and Heart
 Embryonic Tissue Antibodies  >12 publications with CRKL and Embryonic Tissue
 Lymph Node Antibodies  >8 publications with CRKL and Lymph Node
 Lymph Antibodies  >8 publications with CRKL and Lymph
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