NP_001155044.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
14,569 Da
NCBI Official Full Name
transcription factor MafF isoform a
NCBI Official Synonym Full Names
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
NCBI Official Synonym Symbols
NCBI Protein Information
transcription factor MafF; v-maf avian musculoaponeurotic fibrosarcoma oncogene family protein F
UniProt Protein Name
Transcription factor MafF
UniProt Synonym Protein Names
U-Maf; V-maf musculoaponeurotic fibrosarcoma oncogene homolog F
UniProt Entry Name
MAFF_HUMAN
NCBI Summary for MAFF
The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
UniProt Comments for MAFF
MAFF: Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition. Since it lacks a putative transactivation domain, it may behave as a transcriptional repressor when it dimerize among himself. May also serve as a transcriptional activator by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. May be involved in the cellular stress response. Belongs to the bZIP family. Maf subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: nucleoplasm
Molecular Function: sequence-specific DNA binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; in utero embryonic development; regulation of epidermal cell differentiation; parturition; blood coagulation
Research Articles on MAFF
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Products associated with MAFF recombinant protein
Pathways associated with MAFF recombinant protein
Diseases associated with MAFF recombinant protein
Organs/Tissues associated with MAFF recombinant protein
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