NP_002350.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
17,850 Da
NCBI Official Full Name
transcription factor MafG
NCBI Official Synonym Full Names
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
NCBI Official Synonym Symbols
NCBI Protein Information
transcription factor MafG; basic leucine zipper transcription factor MafG
UniProt Protein Name
Transcription factor MafG
UniProt Synonym Protein Names
V-maf musculoaponeurotic fibrosarcoma oncogene homolog G; hMAF
UniProt Entry Name
MAFG_HUMAN
NCBI Summary for MAFG
Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).[supplied by OMIM, Mar 2010]
UniProt Comments for MAFG
MAFG: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF- E2. Activates globin gene expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+). Belongs to the bZIP family. Maf subfamily.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: nucleoplasm
Molecular Function: protein heterodimerization activity; sequence-specific DNA binding; transcription factor activity
Biological Process: regulation of cellular pH; regulation of transcription, DNA-dependent; transcription, DNA-dependent; in utero embryonic development; adult behavior; regulation of epidermal cell differentiation; blood coagulation; regulation of cell proliferation
Research Articles on MAFG
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Products associated with MAFG recombinant protein
Pathways associated with MAFG recombinant protein
Diseases associated with MAFG recombinant protein
Organs/Tissues associated with MAFG recombinant protein
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