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RALA recombinant protein :: V-ral Simian Leukemia Viral Oncogene Homolog A Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS144169 RALA recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

V-ral Simian Leukemia Viral Oncogene Homolog A (RALA), Recombinant Protein

 Also Known As   

Recombinant Human V-ral Simian Leukemia Viral Oncogene Homolog A

 Product Synonym Names    RALA Human; V-ral Simian Leukemia Viral Oncogene Homolog A Human Recombinant; Ras-related protein Ral-A; RALA; RAL; MGC48949
 Product Gene Name   

RALA recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MGSHMA ANKP KGQNSLALHK VIMVGSGGVG KSALTLQFMY DEFVEDYEPT KADSYRKKVV LDGEEVQIDI LDTAGQEDYA AIRDNYFRSG EGFLCVFSIT EMESFAATAD FREQILRVKE DENVPFLLVG NKSDLEDKRQ VSVEEAKNRA EQWNVNYVET SAKTRANVDK VFFDLMREIR ARKMEDSKEK NGKKKRKSLA KRIRERC
 OMIM    179550
 3D Structure    ModBase 3D Structure for P11233
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 Host    E Coli
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 Purity/Purification    Greater than 90.0% as determined by SDS-PAGE.
 Form/Format    The RALA solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 10% glycerol, 2mM DTT, 100mM NaCl and 0.1mM PMSF.
Sterile Filtered colorless solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks.Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of RALA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for RALA recombinant protein

   Description: RALA Human Recombinant fused with a 24 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 227 amino acids (1-203 a.a.) and having a molecular mass of 25.8kDa. The RALA is purified by proprietary chromatographic techniques.

Introduction: Ras-related protein Ral-A (RALA) is a member of the small GTPase superfamily, Ras family of proteins. RALA mediates a distinct downstream signaling pathway from Ras which facilitates cellular transformation. Furthermore, RALA is thought to be involved in various signaling cascades, including regulation of the cytoskeleton, vesicle trafficking, and endocytosis.
 Product Categories/Family for RALA recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; V-ral Simian Leukemia Viral Oncogene
NCBI/Uniprot data below describe general gene information for RALA. It may not necessarily be applicable to this product.
 NCBI GI #    33946329
 NCBI GeneID    5898
 NCBI Accession #    NP_005393.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005402.3 [Other Products]
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 UniProt Primary Accession #    P11233 [Other Products]
 UniProt Secondary Accession #    A4D1W3 [Other Products]
 UniProt Related Accession #    P11233 [Other Products]
 Molecular Weight    23,567 Da
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 NCBI Official Full Name    ras-related protein Ral-A
 NCBI Official Synonym Full Names    v-ral simian leukemia viral oncogene homolog A (ras related)
 NCBI Official Symbol    RALA [Similar Products]
 NCBI Official Synonym Symbols   
RAL
[Similar Products]
 NCBI Protein Information    ras-related protein Ral-A; RAS-like protein A; Ras family small GTP binding protein RALA; ras related GTP binding protein A
 UniProt Protein Name    Ras-related protein Ral-A
 Protein Family    Ras-related protein
 UniProt Gene Name    RALA [Similar Products]
 UniProt Synonym Gene Names    RAL [Similar Products]
 UniProt Entry Name    RALA_HUMAN
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 NCBI Summary for RALA    The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RALA    RALA: Multifuntional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin- dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells. Interacts with RALBP1 via its effector domain. Interacts with EXOC8 and EXOC2. EXOC2 and EXOC8 have overlapping binding sites and compete for RALA binding. Interacts with Clostridium exoenzyme C3. Interacts with RALGPS1. Interacts with LPAR1 and LPAR2. Interacts with ADRBK1 in response to LPAR1 activation. RALA and ADRBK1 mutually inhibit each other's binding to LPAR1. Activated in an LPA-dependent manner by LPAR1 and in an LPA-independent manner by LPAR2. Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase- activating protein (GAP). Belongs to the small GTPase superfamily. Ras family.

Protein type: G protein, monomeric, Ras; G protein; Motility/polarity/chemotaxis; G protein, monomeric

Chromosomal Location of Human Ortholog: 7p15-p13

Cellular Component: cytoplasmic vesicle membrane; cell surface; focal adhesion; endocytic vesicle; plasma membrane; midbody; cleavage furrow

Molecular Function: GTPase activity; protein binding; GDP binding; myosin binding; GTP binding; Edg-2 lysophosphatidic acid receptor binding; ubiquitin protein ligase binding; ATPase binding

Biological Process: positive regulation of filopodium formation; regulation of exocytosis; exocytosis; nerve growth factor receptor signaling pathway; lipid raft localization; viral reproduction; metabolic process; Ras protein signal transduction; actin cytoskeleton reorganization; cytokinesis; signal transduction; chemotaxis
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 Research Articles on RALA    1. expression of K-Ras and RalB and possibly RalA proteins is critical for maintaining low levels of p53, and down-regulation of these GTPases reactivates p53 by significantly enhancing its stability, contributing to suppression of malignant transformation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with RALA recombinant proteinPathways associated with RALA recombinant protein
 Reference Product  PubMed Publications
 RALGDS recombinant protein  >53 publications with RALA and RALGDS
 RALBP1 recombinant protein  >41 publications with RALA and RALBP1
 EXOC2 recombinant protein  >13 publications with RALA and EXOC2
 PLD1 recombinant protein  >12 publications with RALA and PLD1
 ARF6 recombinant protein  >8 publications with RALA and ARF6
 EXOC8 recombinant protein  >8 publications with RALA and EXOC8
 EXOC4 recombinant protein  >3 publications with RALA and EXOC4
 EXOC3 recombinant protein  >3 publications with RALA and EXOC3
 Products by Pathway  Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 ErbB1 Downstream Signaling Pathway antibodies  ErbB1 Downstream Signaling Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 NGF Signalling Via TRKA From The Plasma Membrane Pathway antibodies  NGF Signalling Via TRKA From The Plasma Membrane Pathway Diagram
 Pancreatic Cancer Pathway antibodies  Pancreatic Cancer Pathway Diagram
 Pancreatic Cancer Pathway antibodies  Pancreatic Cancer Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 RalA Downstream Regulated Genes Pathway antibodies  RalA Downstream Regulated Genes Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
Diseases associated with RALA recombinant proteinOrgans/Tissues associated with RALA recombinant protein
 Disease Name  Pubmed Publications
 Cell Transformation, Neoplastic Antibodies  >29 publications with RALA and Cell Transformation, Neoplastic
 Neoplasm Metastasis Antibodies  >15 publications with RALA and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >12 publications with RALA and Adenocarcinoma
 Pancreatic Neoplasms Antibodies  >11 publications with RALA and Pancreatic Neoplasms
 Lung Neoplasms Antibodies  >10 publications with RALA and Lung Neoplasms
 Nervous System Diseases Antibodies  >10 publications with RALA and Nervous System Diseases
 Necrosis Antibodies  >10 publications with RALA and Necrosis
 Urinary Bladder Neoplasms Antibodies  >9 publications with RALA and Urinary Bladder Neoplasms
 Liver Neoplasms Antibodies  >5 publications with RALA and Liver Neoplasms
 Liver Diseases Antibodies  >5 publications with RALA and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >29 publications with RALA and Blood
 Brain Antibodies  >28 publications with RALA and Brain
 Muscle Antibodies  >16 publications with RALA and Muscle
 Lung Antibodies  >15 publications with RALA and Lung
 Kidney Antibodies  >13 publications with RALA and Kidney
 Liver Antibodies  >11 publications with RALA and Liver
 Prostate Antibodies  >11 publications with RALA and Prostate
 Vascular Antibodies  >10 publications with RALA and Vascular
 Bladder Antibodies  >10 publications with RALA and Bladder
 Skin Antibodies  >8 publications with RALA and Skin
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