NP_002872.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,710 Da
NCBI Official Full Name
ras-related protein Ral-B
NCBI Official Synonym Full Names
v-ral simian leukemia viral oncogene homolog B
NCBI Protein Information
ras-related protein Ral-B; RAS-like protein B; ras related GTP binding protein B; v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)
UniProt Protein Name
Ras-related protein Ral-B
UniProt Entry Name
RALB_HUMAN
NCBI Summary for RALB
This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008]
UniProt Comments for RALB
RALB: Multifuntional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Plays a role in the late stages of cytokinesis and is required for the abscission of the bridge joining the sister cells emerging from mitosis. Required for suppression of apoptosis. Interacts with EXOC2 and EXOC8. Interacts with RALBP1 via its effector domain. Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase- activating protein (GAP). Belongs to the small GTPase superfamily. Ras family.
Protein type: G protein; G protein, monomeric, Ras; G protein, monomeric
Chromosomal Location of Human Ortholog: 2q14.2
Cellular Component: plasma membrane; exocyst; autophagic vacuole; midbody
Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; ubiquitin protein ligase binding; ATPase binding
Biological Process: regulation of exocyst localization; positive regulation of protein binding; nerve growth factor receptor signaling pathway; apoptosis; metabolic process; regulation of exocyst assembly; Ras protein signal transduction; cytokinesis; positive regulation of protein amino acid phosphorylation; negative regulation of protein binding; cellular response to starvation; signal transduction
Research Articles on RALB
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Products associated with RALB recombinant protein
Pathways associated with RALB recombinant protein
Diseases associated with RALB recombinant protein
Organs/Tissues associated with RALB recombinant protein
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