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VAPB recombinant protein

Scan QR to view Datasheet Catalog #    MBS203952
SDS-PAGE
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

VAPB, Recombinant Protein

 Also Known As   

VAPB, 1-222aa, Human, His tag, E Coli

 Product Synonym Names    Vesicle-associated membrane protein-associated protein B/C; ALS8; VAMP-B; VAMP-C; VAP-B; VAP-C
 Product Gene Name   

VAPB recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MAKVEQVLSL EPQHELKFRG PFTDVVTTNL KLGNPTDRNV CFKVKTTAPR RYCVRPNSGI IDAGASINVS VMLQPFDYDP NEKSKHKFMV QSMFAPTDTS DMEAVWKEAK PEDLMDSKLR CVFELPAEND KPHDVEINKI ISTTASKTET PIVSKSLSSS LDDTEVKKVM EECKRLQGEV QRLREENKQF KEEDGLRMRK TVQSNSPISA LAPTGKEEGL ST
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 Purity/Purification    > 90% by SDS - PAGE
 Form/Format    Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol
 Concentration    1.0 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag    His-tag
 Expression System    E Coli
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of VAPB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for VAPB recombinant protein

   VAPB, also known as vesicle-associated membrane protein (VAMP)-associated protein B, is a type IV transmembrane protein and member of the VAP family of proteins. This protein may play a role in vesicle trafficking. It is found in plasma and intracellular vesicle membranes as a homodimer and heterodimer with VAPA, and interacts with VAMP1 and VAMP2. Defects in VAPB are a cause of amyotrophic lateral sclerosis type 8 and spinal muscular atrophy autosomal dominant Finkel type. Recombinant human VAPB protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
 Product Categories/Family for VAPB recombinant protein    Neuroscience
 Applications Tested/Suitable for VAPB recombinant protein   

SDS-PAGE

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 SDS-PAGE of VAPB recombinant protein    VAPB recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for VAPB. It may not necessarily be applicable to this product.
 NCBI GI #    4759302
 NCBI GeneID    9217
 NCBI Accession #    NP_004729 [Other Products]
 NCBI GenBank Nucleotide #    NM_004738.4 [Other Products]
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 UniProt Secondary Accession #    O95293; Q9P0H0; A2A2F2 [Other Products]
 UniProt Related Accession #    O95292 [Other Products]
 Molecular Weight    27.1 kDa (242aa) confirmed by MALDI-TOF (molecular weight on SDS-PAGE will appear higher)
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 NCBI Official Full Name    vesicle-associated membrane protein-associated protein B/C isoform 1
 NCBI Official Synonym Full Names    VAMP (vesicle-associated membrane protein)-associated protein B and C
 NCBI Official Symbol    VAPB [Similar Products]
 NCBI Official Synonym Symbols   
ALS8; VAP-B; VAMP-B
[Similar Products]
 NCBI Protein Information    vesicle-associated membrane protein-associated protein B/C; VAMP-associated 33 kDa protein
 UniProt Protein Name    Vesicle-associated membrane protein-associated protein B/C
 Protein Family    Virulence-associated protein
 UniProt Gene Name    VAPB [Similar Products]
 UniProt Synonym Gene Names    VAMP-B/VAMP-C; VAMP-associated protein B/C; VAP-B/VAP-C [Similar Products]
 UniProt Entry Name    VAPB_HUMAN
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 NCBI Summary for VAPB    The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking. [provided by RefSeq, Jul 2008]
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 UniProt Comments for VAPB    VAPB: Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. Defects in VAPB are the cause of amyotrophic lateral sclerosis type 8 (ALS8). ALS8 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms. Defects in VAPB are a cause of spinal muscular atrophy proximal adult autosomal dominant (SMAPAD); also called late-onset spinal muscular atrophy Finkel type. A form of spinal muscular atrophy, a neuromuscular disorder characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. SMAPAD is characterized by proximal muscle weakness that begins in the lower limbs and then progresses to upper limbs, onset in late adulthood (after third decade) and a benign course. Most of the patients remain ambulatory 10 to 40 years after clinical onset. Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 20q13.33

Cellular Component: Golgi membrane; Golgi apparatus; endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane

Molecular Function: protein binding; enzyme binding; protein homodimerization activity; protein heterodimerization activity; FFAT motif binding; microtubule binding; beta-tubulin binding

Biological Process: endoplasmic reticulum organization and biogenesis; cellular calcium ion homeostasis; ER to Golgi vesicle-mediated transport; unfolded protein response, activation of signaling protein activity; sphingolipid metabolic process; positive regulation of viral genome replication; sphingolipid biosynthetic process; unfolded protein response; virus-host interaction; negative regulation of viral protein levels in host cell

Disease: Spinal Muscular Atrophy, Late-onset, Finkel Type; Amyotrophic Lateral Sclerosis 8
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Product References and Citations for VAPB recombinant protein

   Nishimura AL, et al. (2004), Am J Hum Genet., 75(5):822-31.
Hamamoto I., et al. (2005). J Virol., 79(21):13473-82.
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 Research Articles on VAPB    1. The repertoire of VAPB interactors is more diverse than previously anticipated and link VAPB to the function of ATPase complexes such as p97/FAF1 and ASNA1/transmembrane-domain recognition complex.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with VAPB recombinant proteinPathways associated with VAPB recombinant protein
 Reference Product  PubMed Publications
 VAPA recombinant protein  >40 publications with VAPB and VAPA
 OSBP recombinant protein  >2 publications with VAPB and OSBP
 ZFYVE27 recombinant protein  >1 publications with VAPB and ZFYVE27
 Products by Pathway  Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Sphingolipid De Novo Biosynthesis Pathway antibodies  Sphingolipid De Novo Biosynthesis Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
Diseases associated with VAPB recombinant proteinOrgans/Tissues associated with VAPB recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >70 publications with VAPB and Nervous System Diseases
 Atrophy Antibodies  >12 publications with VAPB and Atrophy
 Nerve Degeneration Antibodies  >7 publications with VAPB and Nerve Degeneration
 Amyotrophic Lateral Sclerosis 8 Antibodies  >7 publications with VAPB and Amyotrophic Lateral Sclerosis 8
 Liver Diseases Antibodies  >3 publications with VAPB and Liver Diseases
 Chromosome Aberrations Antibodies  >2 publications with VAPB and Chromosome Aberrations
 Necrosis Antibodies  >2 publications with VAPB and Necrosis
 Adenocarcinoma Antibodies  >2 publications with VAPB and Adenocarcinoma
 Cognition Disorders Antibodies  >1 publications with VAPB and Cognition Disorders
 Hyperplasia Antibodies  >1 publications with VAPB and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >16 publications with VAPB and Muscle
 Brain Antibodies  >15 publications with VAPB and Brain
 Nerve Antibodies  >14 publications with VAPB and Nerve
 Lymph Antibodies  >8 publications with VAPB and Lymph
 Lymph Node Antibodies  >8 publications with VAPB and Lymph Node
 Lung Antibodies  >4 publications with VAPB and Lung
 Eye Antibodies  >3 publications with VAPB and Eye
 Liver Antibodies  >3 publications with VAPB and Liver
 Bone Antibodies  >3 publications with VAPB and Bone
 Vascular Antibodies  >2 publications with VAPB and Vascular
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