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VHL recombinant protein

Scan QR to view Datasheet Catalog #    MBS835911
SDS-PAGE
Unit / Price
0.1 mg  /  $265 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

VHL, Recombinant Protein

★Popular Item★
 Also Known As   

VHL protein, betadomain protein (His tag)

 Product Synonym Names    HRCA1 protein; RCA1 protein; VHL 1 protein; VHL1 protein; G7 protein protein; Von Hippel-Lindau tumor suppressor isoform 1 protein; von Hippel Lindau tumor suppressor protein; Von Hippel-Lindau tumor suppressor isoform 1 pVHL protein; RCA 1 protein; HRCA 1 protein; VHLH protein; von Hippel Lindau syndrome protein; Elongin binding protein protein; Von Hippel Lindau disease tumor suppressor protein; VHL protein
 Product Gene Name   

VHL recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    1-154 amino acids: MGSSHHHHHH SSGLVPRGSH MPRRAENWDE AEVGAEEAGV EEYGPEEDGG EESGAEESGP EESGPEELGA EEEMEAGRPR PVLRSVNSRE PSQVIFCNRS PRVVLPVWLN FDGEPQPYPT LPPGTGRRIH SYRGHLWLFR DAGTHDGLLV NQTELFVPSL NVDGQPIFAN ITLP
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 Host    Human
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 Purity/Purification    > 95% pure
 Form/Format    Supplied as a liquid in PBS, pH 7.4, containing 2mM EDTA.
 Concentration    1 mg/ml (lot specific)
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 Protein Type    Recombinant
 Biological Significance    Von Hippel-Lindau disease(VHL) is a dominant inherited syndrome characterized by the predisposition to develop various kinds of benign and malignant tumors, including clear cell renal carcinomas, pheochromocytomas and hemangioblastomas of the central nervous system and retina. VHL syndrome is caused by germline mutation in the VHL tumor suppressor, and VHL tumors are associated with loss or mutation of the remaining wild-type allele. VHL has two domains: a roughly 100-residue NH2-terminal domain rich in beta sheet (beta-domain) and a smaller alpha-helical domain (alpha-domain), held together by two linkers and a polar interface. VHL protein is also involved in the degradation of hypoxia-inducible factor (HIF). VHL beta-domain(1-154aa) was overexpressed in E Coli and purified by using conventional chromatography techniques
 Expression System    E Coli
 Tag/Conjugate    His tag
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 Preparation and Storage    Store at 4 degree C for short term storage (1/2 weeks). Aliquot and store at -20 degree C or - 70 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of VHL recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for VHL recombinant protein

   Purified recombinant Human VHL protein, betadomain protein
 Product Categories/Family for VHL recombinant protein    Cancer; Conjugated Proteins
 Applications Tested/Suitable for VHL recombinant protein   

SDS-PAGE

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 SDS-PAGE of VHL recombinant protein    Figure annotation denotes ug of protein loaded and % gel used.
VHL recombinant protein SDS-PAGE image
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 Molecular Weight    19.2 kDa (174 aa), confirmed by MALDI-TOF.
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 Protein Family    Von Hippel-Lindau disease tumor suppressor
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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