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VEGFB recombinant protein :: Vascular Endothelial Growth Factor B Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143805 VEGFB recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $4,870 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Vascular Endothelial Growth Factor B (VEGFB), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Vascular Endothelial Growth Factor B

 Product Synonym Names    VEGFB Human; Vascular Endothelial Growth Factor-B Human Recombinant; Vascular endothelial growth factor B; VEGF-B; VRF; VEGFL; VEGF-related factor; VEGFB
 Product Gene Name   

VEGFB recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MPVSQPDAPG HQRKVVSWID VYTRATCQPR EVVVPLTVEL MGTVAKQLVP SCVTVQRCGG CCPDDGLECV PTGQHQVRMQ ILMIRYPSSQ LGEMSLEEHS QCECRPKKKD SAVKPDRAAT PHHRPQPRSV PGWDSAPGAP SPADITHPTP APGPSAHAAP STTSALTPGP AAAAADAAAS SVAKGGA.
 OMIM    601398
 3D Structure    ModBase 3D Structure for P49765
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 Host    E Coli
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 Purity/Purification    Greater than 90.0% as determined by SDS-PAGE.
 Form/Format    The VEGFB protein (1mg/ml) solution contains 20mM Tris-HCl buffer pH 7.5 & 10% glycerol.
 Concentration    1mg/ml (lot specific)
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 Biological Activity    Measured in a cell proliferation assay using NIH-3T3 mouse embryonic fibroblast. The ED50 for this effect is < 1ng/ml corresponding to a specific activity of less than 1,000,000units/mg.
 Physical Appearance    Sterile Filtered colorless liquid formulation.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of VEGFB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for VEGFB recombinant protein

   Description: VEGFB Human Recombinant produced in E Coli is a double, non-glycosylated, polypeptide chain containing 207 amino acids (22-207) and having a molecular mass of 21.6 kDa (molecular weight on SDS-PAGE will appear higher).The VEGFB is fused to a 20 amino acid His Tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: VEGFB is a growth factor for endothelial cells. VEGFB 167 a.a. binds heparin and neuropilin-1 while the binding to neuropilin-1 of VEGFB 186 a.a. is regulated by proteolysis. Overexpression of VEGFB in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy. Increased VEGFB expression is associated with hepatocellular carcinoma. VEGF-B has restricted angiogenic activity in the ischemic heart. VEGFB binds to VEGFR1, Flt1, but not to VEGFR2 and VEGFR3. VEGFB is homodimeric, heparin-binding glycoprotein involved in embryonic angiogenesis and vasculogenesis.
 Product Categories/Family for VEGFB recombinant protein    CYTOKINES AND GROWTH FACTORS; Growth Factors; VEGF
NCBI/Uniprot data below describe general gene information for VEGFB. It may not necessarily be applicable to this product.
 NCBI GI #    344179103
 NCBI GeneID    7423
 NCBI Accession #    NP_001230662.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001243733.1 [Other Products]
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 UniProt Primary Accession #    P49765 [Other Products]
 UniProt Secondary Accession #    Q16528 [Other Products]
 UniProt Related Accession #    P49765 [Other Products]
 Molecular Weight    21,261 Da
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 NCBI Official Full Name    vascular endothelial growth factor B isoform VEGFB-167
 NCBI Official Synonym Full Names    vascular endothelial growth factor B
 NCBI Official Symbol    VEGFB [Similar Products]
 NCBI Official Synonym Symbols   
VRF; VEGFL
[Similar Products]
 NCBI Protein Information    vascular endothelial growth factor B; VEGF-related factor
 UniProt Protein Name    Vascular endothelial growth factor B
 UniProt Synonym Protein Names   
VEGF-related factor; VRF
 Protein Family    Vascular endothelial growth factor
 UniProt Gene Name    VEGFB [Similar Products]
 UniProt Synonym Gene Names    VRF; VEGF-B; VRF [Similar Products]
 UniProt Entry Name    VEGFB_HUMAN
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 NCBI Summary for VEGFB    This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011]
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 UniProt Comments for VEGFB    VEGFB: Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis. Homodimer; disulfide-linked. Can also form heterodimer with VEGF. Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas. Belongs to the PDGF/VEGF growth factor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted; Cytokine; Cell cycle regulation

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: extracellular space; membrane; extracellular region

Molecular Function: heparin binding; protein binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity; vascular endothelial growth factor receptor 1 binding; chemoattractant activity

Biological Process: response to drug; protein amino acid O-linked glycosylation; platelet activation; positive regulation of vascular permeability; positive regulation of vascular endothelial growth factor receptor signaling pathway; induction of positive chemotaxis; positive regulation of protein kinase B signaling cascade; positive regulation of peptidyl-tyrosine phosphorylation; platelet degranulation; positive chemotaxis; positive regulation of cell division; positive regulation of endothelial cell proliferation; negative regulation of neuron apoptosis; angiogenesis; blood coagulation; vascular endothelial growth factor receptor signaling pathway; negative regulation of apoptosis; cardiac muscle contraction
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 Research Articles on VEGFB    1. Roles of vascular endothelial growth factor in amyotrophic lateral sclerosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with VEGFB recombinant proteinPathways associated with VEGFB recombinant protein
 Reference Product  PubMed Publications
 FLT1 recombinant protein  >10 publications with VEGFB and FLT1
 KDR recombinant protein  >6 publications with VEGFB and KDR
 NRP1 recombinant protein  >4 publications with VEGFB and NRP1
 FLT4 recombinant protein  >3 publications with VEGFB and FLT4
 ERBB2 recombinant protein  >2 publications with VEGFB and ERBB2
 EGFR recombinant protein  >1 publications with VEGFB and EGFR
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Heart Development Pathway antibodies  Heart Development Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
Diseases associated with VEGFB recombinant proteinOrgans/Tissues associated with VEGFB recombinant protein
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >18 publications with VEGFB and Disease Models, Animal
 Heart Diseases Antibodies  >11 publications with VEGFB and Heart Diseases
 Neoplasm Invasiveness Antibodies  >7 publications with VEGFB and Neoplasm Invasiveness
 Hypertrophy Antibodies  >7 publications with VEGFB and Hypertrophy
 Edema Antibodies  >7 publications with VEGFB and Edema
 Inflammation Antibodies  >6 publications with VEGFB and Inflammation
 Liver Diseases Antibodies  >5 publications with VEGFB and Liver Diseases
 Neoplasm Metastasis Antibodies  >5 publications with VEGFB and Neoplasm Metastasis
 Hypertension Antibodies  >5 publications with VEGFB and Hypertension
 Myocardial Ischemia Antibodies  >5 publications with VEGFB and Myocardial Ischemia
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >96 publications with VEGFB and Vascular
 Blood Antibodies  >38 publications with VEGFB and Blood
 Heart Antibodies  >16 publications with VEGFB and Heart
 Muscle Antibodies  >14 publications with VEGFB and Muscle
 Brain Antibodies  >11 publications with VEGFB and Brain
 Lung Antibodies  >9 publications with VEGFB and Lung
 Placenta Antibodies  >7 publications with VEGFB and Placenta
 Liver Antibodies  >7 publications with VEGFB and Liver
 Eye Antibodies  >7 publications with VEGFB and Eye
 Kidney Antibodies  >5 publications with VEGFB and Kidney
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