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VEGFR1 recombinant protein :: Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2011780 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
SDS-PAGE
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.05 mg  /  $185 +1 FREE 8GB USB
0.1 mg  /  $260 +1 FREE 8GB USB
0.2 mg  /  $315 +1 FREE 8GB USB
0.5 mg  /  $600 +1 FREE 8GB USB
1 mg  /  $890 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Vascular Endothelial Growth Factor Receptor 1 (VEGFR1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Vascular Endothelial Growth Factor Receptor 1 (VEGFR1)

 Product Gene Name   

VEGFR1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with two N-terminal Tags, His-tag and S-tag, its sequence is listed below.
MHHHHHHSSG LVPRGSGMKE TAAAKFERQH MDSPDLGTDD DDKAMADIGS EF-SRDKGLY T CRVKSGSSFR TFNTSVHVYE KGFISVKHRK QQVQETIAGK RSHRLSMKVK AFPSPEVVWL KDGVPATEKS ARYSVHGYSL IIKDVTAEDA GDYTILLGIK QSKLFRNLTA TLIVNVKPQI YEKSVSSLPS PPLYPLGSRQ VLTCTVYGIP QPTIKWLWHP CHYNHSKERN DFCFGSEESF ILDSSSNIGN RIEGITQRMM VIEGTNKTVS TLVV
 Chromosome Location    Chromosome: 12; NC_005111.3 (10927827..10959880, complement). Location: 12p11
 3D Structure    ModBase 3D Structure for P53767
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 Host    E Coli
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 Purity/Purification    > 95%
 Form/Format    Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
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 Organism    Rattus norvegicus (Rat)
 Expression System    Prokaryotic expression
 Residues    Ser303~Val524 (Accession # P53767) with two N-terminal Tags, His-tag and S-tag
 Endotoxin Level    <1.0EU per 1ug (determined by the LAL method)
 Reconstitution    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of VEGFR1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for VEGFR1 recombinant protein

   About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.
 Applications Tested/Suitable for VEGFR1 recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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 SDS-PAGE of VEGFR1 recombinant protein    VEGFR1 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for VEGFR1. It may not necessarily be applicable to this product.
 NCBI GI #    11276093
 NCBI GeneID    54251
 NCBI Accession #    NP_062179.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_019306.1 [Other Products]
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 UniProt Primary Accession #    P53767 [Other Products]
 UniProt Related Accession #    P53767 [Other Products]
 Molecular Weight    30.7kDa
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 NCBI Official Full Name    vascular endothelial growth factor receptor 1
 NCBI Official Synonym Full Names    FMS-related tyrosine kinase 1
 NCBI Official Symbol    Flt1 [Similar Products]
 NCBI Official Synonym Symbols   
VEGFR-1
[Similar Products]
 NCBI Protein Information    vascular endothelial growth factor receptor 1; FLT-1; FMS-like tyrosine kinase 1; tyrosine-protein kinase receptor FLT; vascular endothelial growth factor receptor-1; Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
 UniProt Protein Name    Vascular endothelial growth factor receptor 1
 UniProt Synonym Protein Names   
Fms-like tyrosine kinase 1; FLT-1; Tyrosine-protein kinase receptor FLT
 UniProt Gene Name    Flt1 [Similar Products]
 UniProt Synonym Gene Names    Flt-1; Vegfr1; VEGFR-1; FLT-1 [Similar Products]
 UniProt Entry Name    VGFR1_RAT
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 NCBI Summary for VEGFR1    tyrosine kinase receptor for vascular endothelial growth factor; may play a role in cell proliferation and cell survival [RGD, Feb 2006]
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 UniProt Comments for VEGFR1    VEGFR1: a receptor tyrosine kinase of the VEGFR family. Receptor for VEGF, VEGFB and PGF. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Two splice variant isoforms have been described. Isoform SFlt1 may have an inhibitory role in angiogenesis.

Protein type: EC 2.7.10.1; Kinase, protein; Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); TK group; VEGFR family

Cellular Component: focal adhesion; integral to plasma membrane; plasma membrane; endosome; receptor complex

Molecular Function: identical protein binding; vascular endothelial growth factor receptor activity; growth factor binding; transmembrane receptor protein tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; ATP binding

Biological Process: peptidyl-tyrosine phosphorylation; activation of MAPKK activity; positive regulation of smooth muscle cell proliferation; protein amino acid autophosphorylation; chemotaxis; protein amino acid phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; monocyte chemotaxis; positive regulation of MAP kinase activity; positive regulation of fibroblast proliferation; positive regulation of cell proliferation; angiogenesis; embryonic morphogenesis; cell differentiation; regulation of smooth muscle contraction; cell migration; intracellular receptor-mediated signaling pathway; positive regulation of phosphoinositide 3-kinase activity; patterning of blood vessels; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of angiogenesis; response to hypoxia; blood vessel morphogenesis; sprouting angiogenesis; vascular endothelial growth factor receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration
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 Research Articles on VEGFR1    1. Report role of TNF-alpha in regulating sFlt-1 production in response to placental ischemia or hypoxia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with VEGFR1 recombinant proteinPathways associated with VEGFR1 recombinant protein
 Reference Product  PubMed Publications
 Vegfa recombinant protein  >145 publications with VEGFR1 and Vegfa
 Pgf recombinant protein  >16 publications with VEGFR1 and Pgf
 Vegfc recombinant protein  >14 publications with VEGFR1 and Vegfc
 Vegfb recombinant protein  >10 publications with VEGFR1 and Vegfb
 Nrp1 recombinant protein  >8 publications with VEGFR1 and Nrp1
 Figf recombinant protein  >4 publications with VEGFR1 and Figf
 Nrp2 recombinant protein  >2 publications with VEGFR1 and Nrp2
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 Id Signaling Pathway antibodies  Id Signaling Pathway Diagram
 Neurophilin Interactions With VEGF And VEGFR Pathway antibodies  Neurophilin Interactions With VEGF And VEGFR Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
Diseases associated with VEGFR1 recombinant proteinOrgans/Tissues associated with VEGFR1 recombinant protein
 Disease Name  Pubmed Publications
 Pre-Eclampsia Antibodies  >260 publications with VEGFR1 and Pre-Eclampsia
 Neoplasms Antibodies  >220 publications with VEGFR1 and Neoplasms
 Hypertension Antibodies  >108 publications with VEGFR1 and Hypertension
 Proteinuria Antibodies  >62 publications with VEGFR1 and Proteinuria
 Nervous System Diseases Antibodies  >46 publications with VEGFR1 and Nervous System Diseases
 Inflammation Antibodies  >46 publications with VEGFR1 and Inflammation
 Brain Diseases Antibodies  >34 publications with VEGFR1 and Brain Diseases
 Necrosis Antibodies  >33 publications with VEGFR1 and Necrosis
 Heart Diseases Antibodies  >31 publications with VEGFR1 and Heart Diseases
 Kidney Diseases Antibodies  >30 publications with VEGFR1 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Placenta Antibodies  >298 publications with VEGFR1 and Placenta
 Lung Antibodies  >64 publications with VEGFR1 and Lung
 Kidney Antibodies  >63 publications with VEGFR1 and Kidney
 Eye Antibodies  >52 publications with VEGFR1 and Eye
 Brain Antibodies  >52 publications with VEGFR1 and Brain
 Heart Antibodies  >51 publications with VEGFR1 and Heart
 Prostate Antibodies  >11 publications with VEGFR1 and Prostate
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