NP_032055.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Related Accession #
Molecular Weight
153,016 Da
NCBI Official Full Name
vascular endothelial growth factor receptor 3
NCBI Official Synonym Full Names
FMS-like tyrosine kinase 4
NCBI Official Synonym Symbols
Chy; Flt-4; VEGFR3; VEGFR-3; AI323512 [Similar Products]
NCBI Protein Information
vascular endothelial growth factor receptor 3
UniProt Protein Name
Vascular endothelial growth factor receptor 3
UniProt Synonym Protein Names
Fms-like tyrosine kinase 4; FLT-4; Tyrosine-protein kinase receptor FLT4
UniProt Synonym Gene Names
UniProt Comments for Flt4
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.
Research Articles on Flt4
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with Flt4 recombinant protein
Pathways associated with Flt4 recombinant protein
Diseases associated with Flt4 recombinant protein
Organs/Tissues associated with Flt4 recombinant protein
|