NP_067499
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
nicotinamide phosphoribosyltransferase
NCBI Official Synonym Full Names
nicotinamide phosphoribosyltransferase
NCBI Official Synonym Symbols
Pbef; Pbef1; AI314458; AI480535; Visfatin; NAmPRTase; 1110035O14Rik [Similar Products]
NCBI Protein Information
nicotinamide phosphoribosyltransferase
UniProt Protein Name
Nicotinamide phosphoribosyltransferase
UniProt Synonym Protein Names
Pre-B-cell colony-enhancing factor 1 homolog; PBEF; Visfatin
UniProt Synonym Gene Names
UniProt Comments for Nampt
The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma (). Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression.
Product References and Citations for Nampt recombinant protein
Stephens JM., et al. (2006) Curr Opin Lipidol. 17:128-31.; Hug C., et al. (2005) Science. 307 (5708):366-7.;
Research Articles on Nampt
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Products associated with Nampt recombinant protein
Pathways associated with Nampt recombinant protein
Diseases associated with Nampt recombinant protein
Organs/Tissues associated with Nampt recombinant protein
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