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CACNA1D recombinant protein :: Voltage-dependent L-type calcium channel subunit alpha-1D (CACNA1D), partial Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1209260 CACNA1D recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $480 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $640 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $655 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $705 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $810 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $885 +1 FREE 8GB USB
1 mg (E-Coli)  /  $995 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $995 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,020 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,050 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,485 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,505 +1 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,605 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $1,990 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Voltage-dependent L-type calcium channel subunit alpha-1D (CACNA1D), partial, Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Chicken Voltage-dependent L-type calcium channel subunit alpha-1D (CACNA1D), partial

 Product Synonym Names    Recombinant Voltage-dependent L-type calcium channel subunit alpha-1D (CACNA1D), partial; Voltage-dependent L-type calcium channel subunit alpha-1D; CHCACHA1D Voltage-gated calcium channel subunit alpha Cav1.3
 Product Gene Name   

CACNA1D recombinant protein

[Similar Products]
 Product Synonym Gene Name    CACNA1D [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1059-1148. Partial, provide a fragment of the complete extracellular domain.
 Sequence    KGKFYKCTDE AKQNPEECRG IYIVYKDGDV DNPMVKERVW QNSDFNFDNV LSAMMALFTV STFEGWPALL YKAIDSNGEN VGPVYNYRVE
 Chromosome Location    Chromosome: 12; NC_006099.3 (7040116..7205466). Location: chromosome: 12
 3D Structure    ModBase 3D Structure for O73700
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Gallus gallus (Chicken)
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 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of CACNA1D recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for CACNA1D. It may not necessarily be applicable to this product.
 NCBI GI #    46048807
 NCBI GeneID    395895
 NCBI Accession #    NP_990365.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_205034.2 [Other Products]
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 UniProt Primary Accession #    O73700 [Other Products]
 UniProt Secondary Accession #    O73701; O73702; O73703; O73704 [Other Products]
 UniProt Related Accession #    O73700 [Other Products]
 Molecular Weight    249,344 Da [Similar Products]
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 NCBI Official Full Name    voltage-dependent L-type calcium channel subunit alpha-1D
 NCBI Official Synonym Full Names    calcium channel, voltage-dependent, L type, alpha 1D subunit
 NCBI Official Symbol    CACNA1D [Similar Products]
 NCBI Protein Information    voltage-dependent L-type calcium channel subunit alpha-1D; CHCACHA1D; voltage-gated calcium channel subunit alpha Cav1.3; L-type voltage-gated calcium channel alpha1D subunit ChCaChA1D
 UniProt Protein Name    Voltage-dependent L-type calcium channel subunit alpha-1D
 UniProt Synonym Protein Names   
CHCACHA1D; Voltage-gated calcium channel subunit alpha Cav1.3
 Protein Family    Voltage-dependent L-type calcium channel
 UniProt Gene Name    CACNA1D [Similar Products]
 UniProt Entry Name    CAC1D_CHICK
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 NCBI Summary for CACNA1D    This gene encodes a member of the voltage-dependent calcium channel protein subunit family. The cDNA for this gene was cloned from hair cells of the cochlea in the chicken inner ear. Study of the similar transmembrane protein in deficient mice reported impaired cardiac function and deafness, suggesting that the encoded protein is required for normal hearing and pacemaker activity in the heart. [provided by RefSeq, Aug 2012]
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 UniProt Comments for CACNA1D    Function: The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group.

Subunit structure: Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity

By similarity. Interacts with RIMBP2.

Subcellular location: Membrane; Multi-pass membrane protein.

Tissue specificity: Expressed in the basilar papilla of the cochlea.

Domain: Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

Sequence similarities: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily. [View classification]
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 Research Articles on CACNA1D    1. A transient Ca(2+) current produced by the Ca(v)3.1 channel is expressed early in development to initiate spontaneous Ca(2+) spikes. Ca(v)1.3 currents, typical of mature hair cells, appeared later in development.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with CACNA1D recombinant proteinDiseases associated with CACNA1D recombinant protein
 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 GnRH Signaling Pathway antibodies  GnRH Signaling Pathway Diagram
 GnRH Signaling Pathway antibodies  GnRH Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Vascular Smooth Muscle Contraction Pathway antibodies  Vascular Smooth Muscle Contraction Pathway Diagram
 Vascular Smooth Muscle Contraction Pathway antibodies  Vascular Smooth Muscle Contraction Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >20 publications with CACNA1D and Nervous System Diseases
 Disease Models, Animal Antibodies  >14 publications with CACNA1D and Disease Models, Animal
 Arrhythmias, Cardiac Antibodies  >9 publications with CACNA1D and Arrhythmias, Cardiac
 Brain Diseases Antibodies  >8 publications with CACNA1D and Brain Diseases
 Bradycardia Antibodies  >8 publications with CACNA1D and Bradycardia
 Deafness Antibodies  >8 publications with CACNA1D and Deafness
 Pain Antibodies  >5 publications with CACNA1D and Pain
 Atrioventricular Block Antibodies  >5 publications with CACNA1D and Atrioventricular Block
 Neoplasms Antibodies  >4 publications with CACNA1D and Neoplasms
 Substance Withdrawal Syndrome Antibodies  >3 publications with CACNA1D and Substance Withdrawal Syndrome
Organs/Tissues associated with CACNA1D recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >63 publications with CACNA1D and Brain
 Heart Antibodies  >21 publications with CACNA1D and Heart
 Head Antibodies  >3 publications with CACNA1D and Head
 Embryonic Tissue Antibodies  >2 publications with CACNA1D and Embryonic Tissue
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