NP_001095190.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
212,029 Da
NCBI Official Full Name
voltage-dependent L-type calcium channel subunit alpha-1S
NCBI Official Synonym Symbols
NCBI Protein Information
voltage-dependent L-type calcium channel subunit alpha-1S
UniProt Protein Name
Voltage-dependent L-type calcium channel subunit alpha-1S
UniProt Synonym Protein Names
Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle; Dihydropyridine receptor alpha-1S subunit
UniProt Synonym Gene Names
UniProt Comments for CACNA1S
Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle (PubMed:9465115, PubMed:15201141, PubMed:25548159, PubMed:27621462, PubMed:29078335). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca2+ release from the sarcplasmic reticulum and ultimately results in muscle contraction (PubMed:9465115 PubMed:15201141, PubMed:27621462). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group.
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Diseases associated with CACNA1S recombinant protein
Organs/Tissues associated with CACNA1S recombinant protein
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