O57483.1
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UniProt Primary Accession #
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NCBI Official Full Name
Voltage-dependent L-type calcium channel subunit alpha-1S
UniProt Protein Name
Voltage-dependent L-type calcium channel subunit alpha-1S
UniProt Synonym Protein Names
FGalpha1S; Voltage-gated calcium channel subunit alpha Cav1.1
UniProt Comments for Voltage-dependent L-type calcium channel subunit alpha-1S
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and B omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle ().
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