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KCNAB2 recombinant protein :: Voltage-gated potassium channel subunit beta-2 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS969550
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $890 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,025 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,200 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,270 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,300 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,355 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,865 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,925 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,060 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,480 +3 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Voltage-gated potassium channel subunit beta-2 (KCNAB2), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Voltage-gated potassium channel subunit beta-2

 Product Synonym Names    K(+) channel subunit beta-2; Kv-beta-2; hKvbeta2
 Product Gene Name   

KCNAB2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS969550 COA    COA PDF
 Sequence Positions    1-367aa; Full Length
 OMIM    601142
 3D Structure    ModBase 3D Structure for Q13303
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of KCNAB2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for KCNAB2 recombinant protein

   Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability. Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity. Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore. Promotes KCNA4 channel closure. Modulates the functional properties of KCNA5. Enhances KCNB2 channel activity. Binds NADPH and has NADPH-dependent aldoketoreductase activity. Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro).
 Product Categories/Family for KCNAB2 recombinant protein    Neuroscience
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 SDS-PAGE of KCNAB2 recombinant protein    KCNAB2 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for KCNAB2. It may not necessarily be applicable to this product.
 NCBI GI #    315434245
 NCBI GeneID    8514
 NCBI Accession #    NP_001186789.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001199860.1 [Other Products]
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 UniProt Primary Accession #    Q13303 [Other Products]
 UniProt Secondary Accession #    O43659; Q2YD85; Q5TG82; Q5TG83; Q6ZNE4; Q99411; A0AVM9; A8K1A4; B0AZR7 [Other Products]
 UniProt Related Accession #    Q13303 [Other Products]
 Molecular Weight    56.97kD
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 NCBI Official Full Name    voltage-gated potassium channel subunit beta-2 isoform 1
 NCBI Official Synonym Full Names    potassium voltage-gated channel subfamily A regulatory beta subunit 2
 NCBI Official Symbol    KCNAB2 [Similar Products]
 NCBI Official Synonym Symbols   
AKR6A5; KCNA2B; HKvbeta2; KV-BETA-2; HKvbeta2.1; HKvbeta2.2
[Similar Products]
 NCBI Protein Information    voltage-gated potassium channel subunit beta-2
 UniProt Protein Name    Voltage-gated potassium channel subunit beta-2
 UniProt Synonym Protein Names   
K(+) channel subunit beta-2; Kv-beta-2; hKvbeta2
 Protein Family    Voltage-gated potassium channel
 UniProt Gene Name    KCNAB2 [Similar Products]
 UniProt Synonym Gene Names    KCNA2B; KCNK2; hKvbeta2 [Similar Products]
 UniProt Entry Name    KCAB2_HUMAN
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 NCBI Summary for KCNAB2    Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2010]
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 UniProt Comments for KCNAB2    Kv-beta2: Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters functional properties of Kv1.4. Forms heteromultimeric complex with alpha subunits. Forms a ternary complex with SQSTM1 and PRKCZ. Belongs to the shaker potassium channel beta subunit family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, potassium

Chromosomal Location of Human Ortholog: 1p36.3

Cellular Component: cell junction; cytosol; extrinsic to internal side of plasma membrane; membrane; microtubule; nerve terminal; plasma membrane; postsynaptic density; voltage-gated potassium channel complex

Molecular Function: aldo-keto reductase activity; potassium channel regulator activity; voltage-gated potassium channel activity

Biological Process: hemopoietic progenitor cell differentiation; neuromuscular process; synaptic transmission
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Product References and Citations for KCNAB2 recombinant protein

   Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product.Mccormack K., McCormack T., Tanouye M.A., Rudy B., Stuehmer W.FEBS Lett. 370:32-36(1995) McCormack K.Rae J.L., Shepard A.R. Complete sequencing and characterization of 21,243 full-length human cDNAs.Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.Nat. Genet. 36:40-45(2004) The DNA sequence and biological annotation of human chromosome 1.Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.Nature 441:315-321(2006) Subunit composition and novel localization of K+ channels in spinal cord.Rasband M.N., Trimmer J.S.3.0.CO;2-Y>J. Comp. Neurol. 429:166-176(2001) Genetic analysis of the mammalian K+ channel beta subunit Kvbeta 2 (Kcnab2) .McCormack K., Connor J.X., Zhou L., Ho L.L., Ganetzky B., Chiu S.Y., Messing A.J. Biol. Chem. 277:13219-13228(2002) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.Sci. Signal. 2:RA46-RA46(2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions.Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.Science 325:834-840(2009) Initial characterization of the human central proteome.Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011) Cdk-mediated phosphorylation of the Kvbeta2 auxiliary subunit regulates Kv1 channel axonal targeting.Vacher H., Yang J.W., Cerda O., Autillo-Touati A., Dargent B., Trimmer J.S.J. Cell Biol. 192:813-824(2011) N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) Crystal structure of human potassium channel Kv beta-subunit (KCNAB2) .Structural genomics consortium (SGC) Submitted (JUN-2005) to the PDB data bank
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 Research Articles on KCNAB2    1. Results identified gain and loss of function mutations which lead to increased and decreased potassium currents enhancing AF.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with KCNAB2 recombinant proteinPathways associated with KCNAB2 recombinant protein
 Reference Product  PubMed Publications
 KCNA2 recombinant protein  >4 publications with KCNAB2 and KCNA2
 KCNA5 recombinant protein  >3 publications with KCNAB2 and KCNA5
 KCNA3 recombinant protein  >2 publications with KCNAB2 and KCNA3
 KCNA1 recombinant protein  >2 publications with KCNAB2 and KCNA1
 KCND2 recombinant protein  >1 publications with KCNAB2 and KCND2
 KCNA4 recombinant protein  >1 publications with KCNAB2 and KCNA4
 Products by Pathway  Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Voltage Gated Potassium Channels Pathway antibodies  Voltage Gated Potassium Channels Pathway Diagram
 Metapathway Biotransformation antibodies  Metapathway Biotransformation Diagram
Diseases associated with KCNAB2 recombinant proteinOrgans/Tissues associated with KCNAB2 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >11 publications with KCNAB2 and Nervous System Diseases
 Epilepsy Antibodies  >6 publications with KCNAB2 and Epilepsy
 Disease Models, Animal Antibodies  >2 publications with KCNAB2 and Disease Models, Animal
 Hyperplasia Antibodies  >2 publications with KCNAB2 and Hyperplasia
 Puberty, Precocious Antibodies  >1 publications with KCNAB2 and Puberty, Precocious
 Central Nervous System Neoplasms Antibodies  >1 publications with KCNAB2 and Central Nervous System Neoplasms
 Memory Disorders Antibodies  >1 publications with KCNAB2 and Memory Disorders
 Learning Disorders Antibodies  >1 publications with KCNAB2 and Learning Disorders
 Necrosis Antibodies  >1 publications with KCNAB2 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >20 publications with KCNAB2 and Brain
 Heart Antibodies  >5 publications with KCNAB2 and Heart
 Muscle Antibodies  >3 publications with KCNAB2 and Muscle
 Blood Antibodies  >2 publications with KCNAB2 and Blood
 Bone Antibodies  >1 publications with KCNAB2 and Bone
 Intestine Antibodies  >1 publications with KCNAB2 and Intestine
 Pancreas Antibodies  >1 publications with KCNAB2 and Pancreas
 Ovary Antibodies  >1 publications with KCNAB2 and Ovary
 Lung Antibodies  >1 publications with KCNAB2 and Lung
 Uncharacterized Tissue Antibodies  >1 publications with KCNAB2 and Uncharacterized Tissue
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