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vWFCP recombinant protein :: Von Willebrand Factor Cleaving Protease Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2034172 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $210 +1 FREE 8GB USB
0.05 mg  /  $460 +1 FREE 8GB USB
0.1 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Von Willebrand Factor Cleaving Protease (vWFCP), Recombinant Protein

 Also Known As   

Recombinant Von Willebrand Factor Cleaving Protease (vWFCP)

 Product Synonym Names    ADAMTS13; TTP; vWF-cp; vWF-cleaving protease; A Disintegrin And Metalloproteinase With A Thrombospondin Type 1 Motif Member 13
 Product Gene Name   

vWFCP recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    274150
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 Host    E Coli
 Species Reactivity    Human
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 Purity/Purification    >95%
 Form/Format    20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300
 Concentration    200ug/mL (lot specific)
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 Source    Prokaryotic expression
 Residues    Val896~Val1131
 Tags    Two N-terminal Tags, His-tag and GST-tag
 Tissue Specificity    Liver
 Subcellular Location    Secreted
 Traits    Freeze-dried powder
 Usage    Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8 degree C for one month.
Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed.The loss rate is less than 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of vWFCP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for vWFCP recombinant protein   

SDS-PAGE; WB; ELISA; IP; CoIP; Purification; Amine Reactive Labeling.
(May be suitable for use in other assays to be determined by the end user.)

 Application Notes for vWFCP recombinant protein    Predicted isoelectric point: 6.4
Predicted Molecular Mass: 55.4kDa
Accurate Molecular Mass: 55kDa as determined by SDS-PAGE reducing conditions
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 Sequence of vWFCP recombinant protein    vWFCP recombinant protein Sequence image
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 SDS-PAGE of vWFCP recombinant protein    vWFCP recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for vWFCP. It may not necessarily be applicable to this product.
 NCBI GI #    16306598
 NCBI GeneID    11093
 NCBI Accession #    AAL17652.1 [Other Products]
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 UniProt Secondary Accession #    Q6UY16; Q710F6; Q711T8; Q96L37; Q9H0G3; Q9UGQ1 [Other Products]
 UniProt Related Accession #    Q76LX8 [Other Products]
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 NCBI Official Full Name    von Willebrand factor-cleaving protease
 NCBI Official Synonym Full Names    ADAM metallopeptidase with thrombospondin type 1 motif 13
 NCBI Official Symbol    ADAMTS13 [Similar Products]
 NCBI Official Synonym Symbols   
VWFCP; C9orf8; vWF-CP; ADAM-TS13; ADAMTS-13
[Similar Products]
 NCBI Protein Information    A disintegrin and metalloproteinase with thrombospondin motifs 13
 UniProt Protein Name    A disintegrin and metalloproteinase with thrombospondin motifs 13
 UniProt Synonym Protein Names   
von Willebrand factor-cleaving protease; vWF-CP; vWF-cleaving protease
 UniProt Gene Name    ADAMTS13 [Similar Products]
 UniProt Synonym Gene Names    C9orf8; ADAM-TS 13; ADAM-TS13; ADAMTS-13; vWF-CP; vWF-cleaving protease [Similar Products]
 UniProt Entry Name    ATS13_HUMAN
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 NCBI Summary for vWFCP    This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
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 UniProt Comments for vWFCP    ADAMTS13: Cleaves the vWF multimers in plasma into smaller forms. Defects in ADAMTS13 are the cause of thrombotic thrombocytopenic purpura congenital (TTP); also known as Upshaw-Schulman syndrome (USS). A hematologic disease characterized by hemolytic anemia with fragmentation of erythrocytes, thrombocytopenia, diffuse and non-focal neurologic findings, decreased renal function and fever. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; EC 3.4.24.87; Extracellular matrix; Secreted; Calcium-binding; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: cell surface; endoplasmic reticulum lumen; extracellular space; proteinaceous extracellular matrix

Molecular Function: calcium ion binding; integrin binding; metalloendopeptidase activity; metallopeptidase activity; protein binding; zinc ion binding

Biological Process: cell-matrix adhesion; cellular protein metabolic process; glycoprotein metabolic process; integrin-mediated signaling pathway; peptide catabolic process; platelet activation; post-translational protein modification; protein amino acid O-linked glycosylation; protein processing; proteolysis; response to toxin

Disease: Thrombotic Thrombocytopenic Purpura, Congenital
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 Research Articles on vWFCP    1. ADAMTS13 activity is reduced and VWF:Ag expression is increased within 4 weeks of TIA or ischaemic stroke onset, and can promote enhanced platelet adhesion and aggregation in response to stimulation with collagen and ADP via VWF-mediated pathways
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with vWFCP recombinant proteinPathways associated with vWFCP recombinant protein
 Reference Product  PubMed Publications
 VWF recombinant protein  >722 publications with vWFCP and VWF
 C1R recombinant protein  >4 publications with vWFCP and C1R
 FURIN recombinant protein  >3 publications with vWFCP and FURIN
 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 O-glycosylation Of TSR Domain-containing Proteins Pathway antibodies  O-glycosylation Of TSR Domain-containing Proteins Pathway Diagram
 O-linked Glycosylation Pathway antibodies  O-linked Glycosylation Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
Diseases associated with vWFCP recombinant proteinOrgans/Tissues associated with vWFCP recombinant protein
 Disease Name  Pubmed Publications
 Purpura, Thrombotic Thrombocytopenic Antibodies  >1076 publications with vWFCP and Purpura, Thrombotic Thrombocytopenic
 Thrombotic Microangiopathies Antibodies  >1009 publications with vWFCP and Thrombotic Microangiopathies
 Kidney Diseases Antibodies  >261 publications with vWFCP and Kidney Diseases
 Purpura, Thrombocytopenic, Idiopathic Antibodies  >176 publications with vWFCP and Purpura, Thrombocytopenic, Idiopathic
 Autoimmune Diseases Antibodies  >148 publications with vWFCP and Autoimmune Diseases
 Inflammation Antibodies  >94 publications with vWFCP and Inflammation
 Liver Diseases Antibodies  >52 publications with vWFCP and Liver Diseases
 Sepsis Antibodies  >50 publications with vWFCP and Sepsis
 Disease Models, Animal Antibodies  >47 publications with vWFCP and Disease Models, Animal
 Necrosis Antibodies  >26 publications with vWFCP and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1107 publications with vWFCP and Blood
 Kidney Antibodies  >141 publications with vWFCP and Kidney
 Liver Antibodies  >109 publications with vWFCP and Liver
 Brain Antibodies  >61 publications with vWFCP and Brain
 Connective Tissue Antibodies  >19 publications with vWFCP and Connective Tissue
 Nerve Antibodies  >8 publications with vWFCP and Nerve
 Ovary Antibodies  >4 publications with vWFCP and Ovary
 Placenta Antibodies  >3 publications with vWFCP and Placenta
 Intestine Antibodies  >3 publications with vWFCP and Intestine
 Eye Antibodies  >1 publications with vWFCP and Eye
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