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WARS recombinant protein

Scan QR to view Datasheet Catalog #    MBS203690
SDS-PAGE
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

WARS, Recombinant Protein

★Popular Item★
 Also Known As   

WARS, 1-471aa, Human, His tag, E Coli

 Product Synonym Names    GAMMA-2; IFI53; IFP53; Tryptophanyl-tRNA synthetase; cytoplasmic; TrpRS; hWRS
 Product Gene Name   

WARS recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MPNSEPASLL ELFNSIATQG ELVRSLKAGN ASKDEIDSAV KMLVSLKMSY KAAAGEDYKA DCPPGNPAPT SNHGPDATEA EEDFVDPWTV QTSSAKGIDY DKLIVRFGSS KIDKELINRI ERATGQRPHH FLRRGIFFSH RDMNQVLDAY ENKKPFYLYT GRGPSSEAMH VGHLIPFIFT KWLQDVFNVP LVIQMTDDEK YLWKDLTLDQ AYSYAVENAK DIIACGFDIN KTFIFSDLDY MGMSSGFYKN VVKIQKHVTF NQVKGIFGFT DSDCIGKISF PAIQAAPSFS NSFPQIFRDR TDIQCLIPCA IDQDPYFRMT RDVAPRIGYP KPALLHSTFF PALQGAQTKM SASDPNSSIF LTDTAKQIKT KVNKHAFSGG RDTIEEHRQF GGNCDVDVSF MYLTFFLEDD DKLEQIRKDY TSGAMLTGEL KKALIEVLQP LIAEHQARRK EVTDEIVKEF MTPRKLSFDF Q
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 Purity/Purification    > 90% by SDS - PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 0.1M NaCl, 1mM DTT, 10% glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag    His-tag
 Expression System    E Coli
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of WARS recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for WARS recombinant protein

   WARS, also known as tryptophanyl-tRNA synthetase, belongs to the class I tRNA synthetase family. Two forms of tryptophanyl tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. WARS catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. It also regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression. Recombinant human WARS protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
 Product Categories/Family for WARS recombinant protein    Angiogenesis
 Applications Tested/Suitable for WARS recombinant protein   

SDS-PAGE

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 SDS-PAGE of WARS recombinant protein    WARS recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for WARS. It may not necessarily be applicable to this product.
 NCBI GI #    47419916
 NCBI GeneID    7453
 NCBI Accession #    NP_776049 [Other Products]
 NCBI GenBank Nucleotide #    NM_173701.1 [Other Products]
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 UniProt Secondary Accession #    P78535; Q502Y0; Q53XB6; Q9UDI5; Q9UDL3; A6NGN1; A6NID3 [Other Products]
 UniProt Related Accession #    P23381 [Other Products]
 Molecular Weight    55.3 kDa (491aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    tryptophan--tRNA ligase, cytoplasmic isoform a
 NCBI Official Synonym Full Names    tryptophanyl-tRNA synthetase
 NCBI Official Symbol    WARS [Similar Products]
 NCBI Official Synonym Symbols   
IFI53; IFP53; GAMMA-2
[Similar Products]
 NCBI Protein Information    tryptophan--tRNA ligase, cytoplasmic; hWRS; interferon-induced protein 53; trpRS; tryptophan tRNA ligase 1, cytoplasmic
 UniProt Protein Name    Tryptophan--tRNA ligase, cytoplasmic
 UniProt Synonym Protein Names   
Interferon-induced protein 53; IFP53; Tryptophanyl-tRNA synthetase; TrpRS; hWRS
 Protein Family    Tryptophan--tRNA ligase
 UniProt Gene Name    WARS [Similar Products]
 UniProt Synonym Gene Names    IFI53; WRS; IFP53; TrpRS; hWRS [Similar Products]
 UniProt Entry Name    SYWC_HUMAN
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 NCBI Summary for WARS    Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for WARS    WARS: Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression. Belongs to the class-I aminoacyl-tRNA synthetase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - tryptophan; Ligase; EC 6.1.1.2; Translation

Chromosomal Location of Human Ortholog: 14q32.31

Cellular Component: cytoplasm; nucleus; cytosol

Molecular Function: protein binding; tryptophan-tRNA ligase activity; ATP binding

Biological Process: negative regulation of cell proliferation; tRNA aminoacylation for protein translation; tryptophanyl-tRNA aminoacylation; translation; gene expression; angiogenesis; regulation of angiogenesis
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Product References and Citations for WARS recombinant protein

   Nagano K., et al. (2004) Oncogene. 23(9):1693-703.
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 Research Articles on WARS    1. Genes within recently identified loci associated with waist-hip ratio (WHR) exhibit fat depot-specific mRNA expression, which correlates with obesity-related traits. Adipose tissue (AT) mRNA expression of 6 genes (TBX15/WARS2, STAB1, PIGC, ZNRF3, GRB14)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with WARS recombinant proteinDiseases associated with WARS recombinant protein
 Products by Pathway  Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies  Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
 Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies  Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
 Cytosolic TRNA Aminoacylation Pathway antibodies  Cytosolic TRNA Aminoacylation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 TRNA Aminoacylation Pathway antibodies  TRNA Aminoacylation Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >1625 publications with WARS and Cardiovascular Diseases
 Pain Antibodies  >946 publications with WARS and Pain
 Poisoning Antibodies  >926 publications with WARS and Poisoning
 Heart Diseases Antibodies  >722 publications with WARS and Heart Diseases
 Inflammation Antibodies  >355 publications with WARS and Inflammation
 Hypertension Antibodies  >319 publications with WARS and Hypertension
 Memory Disorders Antibodies  >265 publications with WARS and Memory Disorders
 Kidney Diseases Antibodies  >263 publications with WARS and Kidney Diseases
 Breast Neoplasms Antibodies  >257 publications with WARS and Breast Neoplasms
 Cognition Disorders Antibodies  >217 publications with WARS and Cognition Disorders
Organs/Tissues associated with WARS recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3044 publications with WARS and Blood
 Brain Antibodies  >2905 publications with WARS and Brain
 Bone Antibodies  >1268 publications with WARS and Bone
 Heart Antibodies  >993 publications with WARS and Heart
 Skin Antibodies  >961 publications with WARS and Skin
 Lung Antibodies  >920 publications with WARS and Lung
 Vascular Antibodies  >880 publications with WARS and Vascular
 Nerve Antibodies  >806 publications with WARS and Nerve
 Eye Antibodies  >752 publications with WARS and Eye
 Muscle Antibodies  >522 publications with WARS and Muscle
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