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WARS recombinant protein

Scan QR to view Datasheet Catalog #    MBS203690
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

WARS, Recombinant Protein

★Popular Item★
 Also Known As   

WARS, 1-471aa, Human, His tag, E Coli

 Product Synonym Names    Tryptophanyl-tRNA synthetase cytoplasmic; GAMMA-2; IFI53; IFP53; Tryptophanyl-tRNA synthetase; cytoplasmic; TrpRS; hWRS
 Product Gene Name   

WARS recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MPNSEPASLL ELFNSIATQG ELVRSLKAGN ASKDEIDSAV KMLVSLKMSY KAAAGEDYKA DCPPGNPAPT SNHGPDATEA EEDFVDPWTV QTSSAKGIDY DKLIVRFGSS KIDKELINRI ERATGQRPHH FLRRGIFFSH RDMNQVLDAY ENKKPFYLYT GRGPSSEAMH VGHLIPFIFT KWLQDVFNVP LVIQMTDDEK YLWKDLTLDQ AYSYAVENAK DIIACGFDIN KTFIFSDLDY MGMSSGFYKN VVKIQKHVTF NQVKGIFGFT DSDCIGKISF PAIQAAPSFS NSFPQIFRDR TDIQCLIPCA IDQDPYFRMT RDVAPRIGYP KPALLHSTFF PALQGAQTKM SASDPNSSIF LTDTAKQIKT KVNKHAFSGG RDTIEEHRQF GGNCDVDVSF MYLTFFLEDD DKLEQIRKDY TSGAMLTGEL KKALIEVLQP LIAEHQARRK EVTDEIVKEF MTPRKLSFDF Q
 OMIM    M77804 mRNA
 3D Structure    ModBase 3D Structure for P23381
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 Host    E Coli
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 Purity/Purification    > 90% by SDS-PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 0.1M NaCl, 1mM DTT, 10% glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of WARS recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for WARS recombinant protein

   WARS, also known as tryptophanyl-tRNA synthetase, belongs to the class I tRNA synthetase family. Two forms of tryptophanyl tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. WARS catalyzes the aminoacylation of tRNA (trp) with tryptophan and is induced by interferon. It also regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression. Recombinant human WARS protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for WARS recombinant protein    Angiogenesis
 Applications Tested/Suitable for WARS recombinant protein   

SDS-PAGE

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 SDS-Page of WARS recombinant protein    WARS recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for WARS. It may not necessarily be applicable to this product.
 NCBI GI #    47419916
 NCBI GeneID    7453
 NCBI Accession #    NP_776049 [Other Products]
 NCBI GenBank Nucleotide #    NM_173701.1 [Other Products]
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 UniProt Primary Accession #    P23381 [Other Products]
 UniProt Secondary Accession #    P78535; Q502Y0; Q53XB6; Q9UDI5; Q9UDL3; A6NGN1; A6NID3 [Other Products]
 UniProt Related Accession #    P23381 [Other Products]
 Molecular Weight    55.3 kDa (491aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    tryptophan--tRNA ligase, cytoplasmic isoform a
 NCBI Official Synonym Full Names    tryptophanyl-tRNA synthetase
 NCBI Official Symbol    WARS [Similar Products]
 NCBI Official Synonym Symbols   
HMN9; IFI53; IFP53; GAMMA-2
[Similar Products]
 NCBI Protein Information    tryptophan--tRNA ligase, cytoplasmic
 UniProt Protein Name    Tryptophan--tRNA ligase, cytoplasmic
 UniProt Synonym Protein Names   
Interferon-induced protein 53; IFP53
 Protein Family    Tryptophan--tRNA ligase
 UniProt Gene Name    WARS [Similar Products]
 UniProt Synonym Gene Names    IFI53; WRS; IFP53; TrpRS; hWRS [Similar Products]
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 NCBI Summary for WARS    Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for WARS    Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression.
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Product References and Citations for WARS recombinant protein

   Nagano K., et al. (2004) Oncogene. 23 (9):1693-703.
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 Research Articles on WARS    1. Based on these results, secretion of full-length tryptophanyl-tRNA synthetase appears to work as a primary defence system against infection, acting before full activation of innate immunity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with WARS recombinant proteinPathways associated with WARS recombinant protein
 Reference Product  PubMed Publications
 MARS recombinant protein  >62 publications with WARS and MARS
 WARS2 recombinant protein  >1 publications with WARS and WARS2
 YARS recombinant protein  >1 publications with WARS and YARS
 Products by Pathway  Pathway Diagram
 Amino Acid Metabolism Pathway antibodies  Amino Acid Metabolism Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies  Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
 Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies  Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
 Cytosolic TRNA Aminoacylation Pathway antibodies  Cytosolic TRNA Aminoacylation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Photodynamic Therapy-induced Unfolded Protein Response Pathway antibodies  Photodynamic Therapy-induced Unfolded Protein Response Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 TRNA Aminoacylation Pathway antibodies  TRNA Aminoacylation Pathway Diagram
Diseases associated with WARS recombinant proteinOrgans/Tissues associated with WARS recombinant protein
 Disease Name  Pubmed Publications
 Poisoning Antibodies  >1507 publications with WARS and Poisoning
 Cardiovascular Diseases Antibodies  >1225 publications with WARS and Cardiovascular Diseases
 Brain Diseases Antibodies  >1201 publications with WARS and Brain Diseases
 Pain Antibodies  >647 publications with WARS and Pain
 Hemorrhage Antibodies  >498 publications with WARS and Hemorrhage
 Heart Diseases Antibodies  >496 publications with WARS and Heart Diseases
 Inflammation Antibodies  >449 publications with WARS and Inflammation
 Disease Models, Animal Antibodies  >433 publications with WARS and Disease Models, Animal
 Liver Diseases Antibodies  >280 publications with WARS and Liver Diseases
 Necrosis Antibodies  >237 publications with WARS and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2809 publications with WARS and Blood
 Brain Antibodies  >2527 publications with WARS and Brain
 Nerve Antibodies  >1684 publications with WARS and Nerve
 Skin Antibodies  >1066 publications with WARS and Skin
 Bone Antibodies  >1023 publications with WARS and Bone
 Lung Antibodies  >909 publications with WARS and Lung
 Vascular Antibodies  >737 publications with WARS and Vascular
 Eye Antibodies  >692 publications with WARS and Eye
 Heart Antibodies  >670 publications with WARS and Heart
 Muscle Antibodies  >419 publications with WARS and Muscle
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