NP_001139770.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,491 Da
NCBI Official Full Name
WW domain-containing adapter protein with coiled-coil isoform 2
NCBI Official Synonym Full Names
WW domain containing adaptor with coiled-coil
NCBI Official Synonym Symbols
Wwp4; AI256735; AI256776; 1110067P07Rik; A230035H12Rik [Similar Products]
NCBI Protein Information
WW domain-containing adapter protein with coiled-coil
UniProt Protein Name
WW domain-containing adapter protein with coiled-coil
UniProt Synonym Gene Names
UniProt Comments for Wac
Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. Also acts as a negative regulator of basal autophagy. Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation. May negatively regulate the ubiquitin proteasome pathway.
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Diseases associated with Wac recombinant protein
Organs/Tissues associated with Wac recombinant protein
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