P58930.2
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UniProt Primary Accession #
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NCBI Official Full Name
Waglerin-4
UniProt Protein Name
Waglerin-4
UniProt Synonym Protein Names
SL-Waglerin-2Cleaved into the following chain:Waglerin-2; Alternative name(s):; Lethal peptide II; Waglerin II
UniProt Entry Name
WAG24_TROWA
UniProt Comments for Waglerin-4
Function: Waglerin-2 selectively blocks the epsilon subunit of muscle nicotinic acetylcholine receptor (nAChR). Has also effects on rodent ionotropic GABA(A)/GABRA1 receptors, since it potentiates I(GABA) in some neurons and depresses I(GABA) in others. In mice, it elicits tachypnea, ocular proctosis, rapid collapse and spasms, whereas no toxic effects on respiration and blood pressure are observed in rats
By similarity.Waglerin-4 selectively blocks the epsilon subunit of muscle nicotinic acetylcholine receptor. It elicits tachypnea, ocular proctosis, rapid collapse and spasms in mice. It causes death by respiratory failure
By similarity.
Subunit structure: Monomer
By similarity.
Subcellular location: Secreted.
Tissue specificity: Expressed by the venom gland.
Toxic dose: LD50 is 0.51-0.583 mg/kg by intraperitoneal injection into mice. Ref.2LD50 of waglerin-2 is 0.51 mg/kg by intraperitoneal injection into mice. Ref.2
Sequence similarities: Belongs to the waglerin family.
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Products associated with Waglerin-4 recombinant protein
Pathways associated with Waglerin-4 recombinant protein
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