NP_033542.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
71,578 Da
NCBI Official Full Name
wee1-like protein kinase isoform 1
NCBI Official Synonym Full Names
WEE 1 homolog 1 (S. pombe)
NCBI Official Synonym Symbols
NCBI Protein Information
wee1-like protein kinase
UniProt Protein Name
Wee1-like protein kinase
UniProt Synonym Protein Names
Wee1A kinase
UniProt Comments for Wee1
Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation ().
Research Articles on Wee1
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Products associated with Wee1 recombinant protein
Pathways associated with Wee1 recombinant protein
Diseases associated with Wee1 recombinant protein
Organs/Tissues associated with Wee1 recombinant protein
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