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Wrn recombinant protein :: Werner syndrome ATP-dependent helicase homolog (Wrn), partial Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1066596 Wrn recombinant protein
Unit / Price
0.5 mg (E-Coli)  /  $930 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $930 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,155 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,155 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,330 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,330 +1 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,790 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,790 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,285 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,620 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Werner syndrome ATP-dependent helicase homolog (Wrn), partial, Recombinant Protein

 Also Known As   

Recombinant Mouse Werner syndrome ATP-dependent helicase homolog (Wrn), partial

 Product Synonym Names    Werner syndrome ATP-dependent helicase homolog; EC=3.6.4.12; Exonuclease WRN; EC=3.1.-.-
 Product Gene Name   

Wrn recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    713-866; Helicase C-terminal domain
 Sequence    DLKPFLVRKA SSAWEFEGPT IIYCPSRKMT EQVTAELGKL NLACRTYHAG MKISERKDVH HRFLRDEIQC VVATVAFGMG INKADIRKVI HYGAPKEMES YYQEIGRAGR DGLQSSCHLL WAPADFNTSR NLLIEIHDEK FRLYKLKMMV KMEK
 3D Structure    ModBase 3D Structure for O09053
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mus musculus (Mouse)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Wrn recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for Wrn recombinant protein

   This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3 to 5 DNA helicase activity, and is also a 3 to 5 exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.
NCBI/Uniprot data below describe general gene information for Wrn. It may not necessarily be applicable to this product.
 NCBI GI #    170763504
 NCBI GeneID    22427
 NCBI Accession #    NP_001116294.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001122822.1 [Other Products]
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 UniProt Primary Accession #    O09053 [Other Products]
 UniProt Secondary Accession #    O09050; Q80YP9; Q9JKD4; Q9Z241; Q9Z242 [Other Products]
 UniProt Related Accession #    O09053 [Other Products]
 Molecular Weight    157,204 Da
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 NCBI Official Full Name    Werner syndrome ATP-dependent helicase homolog
 NCBI Official Synonym Full Names    Werner syndrome homolog (human)
 NCBI Official Symbol    Wrn [Similar Products]
 NCBI Official Synonym Symbols   
AI846146
[Similar Products]
 NCBI Protein Information    Werner syndrome ATP-dependent helicase homolog; exonuclease WRN
 UniProt Protein Name    Werner syndrome ATP-dependent helicase homolog
 UniProt Synonym Protein Names   
Exonuclease WRN (EC:3.1.-.-)
 Protein Family    Werner syndrome ATP-dependent helicase
 UniProt Gene Name    Wrn [Similar Products]
 UniProt Entry Name    WRN_MOUSE
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 UniProt Comments for Wrn    WRN: Multifunctional enzyme that has both magnesium and ATP- dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double- stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Monomer, and homooligomer. May exist as homodimer, homotrimer, homotetramer and/or homohexamer. Homotetramer, or homohexamer, when bound to DNA. Interacts via its N-terminal domain with WRNIP1. Interacts with EXO1, PCNA and SUPV3L1. Belongs to the helicase family. RecQ subfamily.

Protein type: Cell cycle regulation; Nucleolus; Helicase; EC 3.6.4.12; DNA-binding; DNA repair, damage

Cellular Component: MutLalpha complex; nucleoplasm; centrosome; nucleolus; intracellular; nucleus

Molecular Function: G-quadruplex DNA binding; protein homodimerization activity; metal ion binding; ATPase activity; 3'-5' DNA helicase activity; magnesium ion binding; bubble DNA binding; four-way junction helicase activity; Y-form DNA binding; ATP-dependent 3'-5' DNA helicase activity; nucleic acid binding; exonuclease activity; protein complex binding; 3'-5' exonuclease activity; catalytic activity; ATP binding; nuclease activity; hydrolase activity; nucleotide binding; ATP-dependent helicase activity; helicase activity; T/G mismatch-specific endonuclease activity; phosphoric ester hydrolase activity; ATP-dependent DNA helicase activity; protein binding; DNA helicase activity; DNA binding; manganese ion binding

Biological Process: nucleolus to nucleoplasm transport; metabolic process; positive regulation of hydrolase activity; cell aging; multicellular organismal aging; DNA repair; replicative cell aging; cellular response to starvation; response to UV-C; DNA duplex unwinding; DNA recombination; replication fork processing; regulation of apoptosis; DNA synthesis during DNA repair; cellular metabolic process; base-excision repair; double-strand break repair; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; regulation of growth rate; response to oxidative stress; DNA replication; DNA metabolic process; response to DNA damage stimulus; telomere maintenance
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 Research Articles on Wrn    1. Studies show that in the context of Myc-associated tumorigenesis, loss of Wrn amplifies the DNA damage response, both in preneoplastic and neoplastic tissue, engaging activation of tumor suppressor pathways.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Wrn recombinant proteinDiseases associated with Wrn recombinant protein
 Reference Product  PubMed Publications
 Wrnip1 recombinant protein  >9 publications with Wrn and Wrnip1
 Disease Name  Pubmed Publications
 Werner Syndrome Antibodies  >602 publications with Wrn and Werner Syndrome
 Aging, Premature Antibodies  >276 publications with Wrn and Aging, Premature
 Chromosome Aberrations Antibodies  >40 publications with Wrn and Chromosome Aberrations
 Carcinoma Antibodies  >31 publications with Wrn and Carcinoma
 Nervous System Diseases Antibodies  >25 publications with Wrn and Nervous System Diseases
 Gastrointestinal Diseases Antibodies  >24 publications with Wrn and Gastrointestinal Diseases
 Adenocarcinoma Antibodies  >20 publications with Wrn and Adenocarcinoma
 Anemia Antibodies  >17 publications with Wrn and Anemia
 Cell Transformation, Neoplastic Antibodies  >17 publications with Wrn and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >16 publications with Wrn and Breast Neoplasms
Organs/Tissues associated with Wrn recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >39 publications with Wrn and Skin
 Brain Antibodies  >17 publications with Wrn and Brain
 Liver Antibodies  >17 publications with Wrn and Liver
 Lung Antibodies  >13 publications with Wrn and Lung
 Bone Marrow Antibodies  >8 publications with Wrn and Bone Marrow
 Embryonic Tissue Antibodies  >8 publications with Wrn and Embryonic Tissue
 Eye Antibodies  >7 publications with Wrn and Eye
 Testis Antibodies  >6 publications with Wrn and Testis
 Pancreas Antibodies  >3 publications with Wrn and Pancreas
 Spleen Antibodies  >2 publications with Wrn and Spleen
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