Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow Wrn  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Osteoprotegerin (TNFRSF11B) Antibody
 • C Reactive Protein (CRP) Antibody
 • Platelet-derived microparticles (PDMP) ELISA Kit
 • APOBEC1 Peptide
 • Prolactin-Luteotropic Hormone (PRL-LTH) ELISA Kit
 • PP ELISA Kit
 • Lipid Peroxidation Assay Kit
 • SH3-domain GRB2-like 1 (SH3GL1) ELISA Kit
 • 5-aminolevulinate synthase, nonspecific, mitochondrial (ALAS... Recombinant Protein
 • Glutamate--tRNA ligase 1 (gltX1) Recombinant Protein
 • MLANA Antibody
 • Alpha-1 Acid Glycoprotein (A1GP) Protein
 • VEGFA Antibody
 • Leptin (LEP) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

Wrn recombinant protein :: Werner syndrome ATP-dependent helicase homolog (Wrn) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1066596 Wrn recombinant protein
Unit / Price
0.5 mg (E-Coli)  /  $930 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $930 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,155 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,155 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,330 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,330 +1 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,790 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,790 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,285 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,620 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Werner syndrome ATP-dependent helicase homolog (Wrn), Recombinant Protein

 Also Known As   

Recombinant Mouse Werner syndrome ATP-dependent helicase homolog (Wrn) , partial

 Product Gene Name   

Wrn recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence Positions    713-866; Helicase C-terminal domain
 Sequence    DLKPFLVRKA SSAWEFEGPT IIYCPSRKMT EQVTAELGKL NLACRTYHAG MKISERKDVH HRFLRDEIQC VVATVAFGMG INKADIRKVI HYGAPKEMES YYQEIGRAGR DGLQSSCHLL WAPADFNTSR NLLIEIHDEK FRLYKLKMMV KMEK
 3D Structure    ModBase 3D Structure for O09053
Section Bar
 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
Section Bar
 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
Section Bar
 Species    Mouse
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
Section Bar
 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Wrn recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for Wrn recombinant protein

   This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3 to 5 DNA helicase activity, and is also a 3 to 5 exonuclease. Based on interactions between this protein and Ku70
80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.
NCBI/Uniprot data below describe general gene information for Wrn. It may not necessarily be applicable to this product.
 NCBI GI #    170763504
 NCBI GeneID    22427
 NCBI Accession #    NP_001116294.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001122822.1 [Other Products]
Section Bar
 UniProt Primary Accession #    O09053 [Other Products]
 UniProt Secondary Accession #    O09050; Q80YP9; Q9JKD4; Q9Z241; Q9Z242 [Other Products]
 UniProt Related Accession #    O09053 [Other Products]
 Molecular Weight    157,204 Da
Table BarTOPTable Bar
 NCBI Official Full Name    Werner syndrome ATP-dependent helicase homolog
 NCBI Official Synonym Full Names    Werner syndrome RecQ like helicase
 NCBI Official Symbol    Wrn [Similar Products]
 NCBI Official Synonym Symbols   
AI846146
[Similar Products]
 NCBI Protein Information    Werner syndrome ATP-dependent helicase homolog
 UniProt Protein Name    Werner syndrome ATP-dependent helicase homolog
 UniProt Synonym Protein Names   
Exonuclease WRN (EC:3.1.-.-)
 Protein Family    Werner syndrome ATP-dependent helicase
 UniProt Gene Name    Wrn [Similar Products]
Section Bar
 UniProt Comments for Wrn    Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (). Plays a role in double-strand break repair after gamma-irradiation ().
Table BarTOPTable Bar
 Research Articles on Wrn    1. A mislocalization of the Wrn mutant protein in the liver endoplasmic reticulum fraction increased oxidative stress in that cellular compartment. Vitamin C reversed this oxidative stress.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with Wrn recombinant proteinDiseases associated with Wrn recombinant protein
 Reference Product  PubMed Publications
 Wrnip1 recombinant protein  >9 publications with Wrn and Wrnip1
 Disease Name  Pubmed Publications
 Werner Syndrome Antibodies  >539 publications with Wrn and Werner Syndrome
 Aging, Premature Antibodies  >247 publications with Wrn and Aging, Premature
 Neoplasms Antibodies  >132 publications with Wrn and Neoplasms
 Chromosome Aberrations Antibodies  >39 publications with Wrn and Chromosome Aberrations
 Ataxia Antibodies  >29 publications with Wrn and Ataxia
 Carcinoma Antibodies  >27 publications with Wrn and Carcinoma
 Nervous System Diseases Antibodies  >23 publications with Wrn and Nervous System Diseases
 Gastrointestinal Diseases Antibodies  >21 publications with Wrn and Gastrointestinal Diseases
 Intestinal Neoplasms Antibodies  >17 publications with Wrn and Intestinal Neoplasms
 Adenocarcinoma Antibodies  >17 publications with Wrn and Adenocarcinoma
Organs/Tissues associated with Wrn recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >34 publications with Wrn and Skin
 Brain Antibodies  >14 publications with Wrn and Brain
 Lung Antibodies  >12 publications with Wrn and Lung
 Liver Antibodies  >10 publications with Wrn and Liver
 Embryonic Tissue Antibodies  >8 publications with Wrn and Embryonic Tissue
 Testis Antibodies  >6 publications with Wrn and Testis
 Bone Marrow Antibodies  >3 publications with Wrn and Bone Marrow
 Eye Antibodies  >3 publications with Wrn and Eye
 Spleen Antibodies  >2 publications with Wrn and Spleen
 Prostate Antibodies  >2 publications with Wrn and Prostate
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions