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Wt1 recombinant protein :: Wilms tumor protein homolog (Wt1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS957212
SDS-PAGE
Unit / Price
0.05 mg (E-Coli)  /  $865 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,085 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,160 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,280 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,290 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,335 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,380 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,460 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,820 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,980 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,020 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,225 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,605 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Wilms tumor protein homolog (Wt1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Wilms tumor protein homolog (Wt1)

 Product Gene Name   

Wt1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-449aa, Full length protein
 Sequence    MGSDVRDLNA LLPAVSSLGG GGGGCGLPVS GARQWAPVLD FAPPGASAYG SLGGPAPPPA PPPPPPPPHS FIKQEPSWGG AEPHEEQCLS AFTLHFSGQF TGTAGACRYG PFGPPPPSQA SSGQARMFPN APYLPSCLES QPTIRNQGYS TVTFDGAPSY GHTPSHHAAQ FPNHSFKHED PMGQQGSLGE QQYSVPPPVY GCHTPTDSCT GSQALLLRTP YSSDNLYQMT SQLECMTWNQ MNLGATLKGM AAGSSSSVKW TEGQSNHGIG YESENHTAPI LCGAQYRIHT HGVFRGIQDV RRVSGVAPTL VRSASETSEK RPFMCAYPGC NKRYFKLSHL QMHSRKHTGE KPYQCDFKDC ERRFSRSDQL KRHQRRHTGV KPFQCKTCQR KFSRSDHLKT HTRTHTGKTS EKPFSCRWHS CQKKFARSDE LVRHHNMHQR NMTKLHVAL
 3D Structure    ModBase 3D Structure for P22561
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mouse
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Wt1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Wt1 recombinant protein

   This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline
glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm s tumors. Multiple transcript variants, resulting from alternative splicing at two coding exons, have been well characterized. There is also evidence for the use of non-AUG (CUG) translation initiation site upstream of, and in-frame with the first AUG, leading to additional isoforms. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.
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 SDS-PAGE of Wt1 recombinant protein    Wt1 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for Wt1. It may not necessarily be applicable to this product.
 NCBI GI #    139779
 NCBI GeneID    22431
 NCBI Accession #    P22561.1 [Other Products]
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 UniProt Primary Accession #    P22561 [Other Products]
 UniProt Secondary Accession #    A2A402 [Other Products]
 UniProt Related Accession #    P22561 [Other Products]
 Molecular Weight    54,943 Da
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 NCBI Official Full Name    Wilms tumor protein homolog
 NCBI Official Synonym Full Names    Wilms tumor 1 homolog
 NCBI Official Symbol    Wt1 [Similar Products]
 NCBI Official Synonym Symbols   
Wt-1; D630046I19Rik
[Similar Products]
 NCBI Protein Information    Wilms tumor protein homolog
 UniProt Protein Name    Wilms tumor protein homolog
 Protein Family    Wilms tumor protein
 UniProt Gene Name    Wt1 [Similar Products]
 UniProt Synonym Gene Names    Wt-1 [Similar Products]
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 NCBI Summary for Wt1    This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It plays an essential role in the normal development of the urogenital system, and the orthologous human gene is mutated in a small subset of patients with Wilm's tumors. Alternative splicing has been noted for this gene, however, the full-length nature of these variants is not known. The mRNA for this gene has been shown to initiate translation from non-AUG (CUG) and AUG translation start sites, resulting in different isoforms. [provided by RefSeq, Apr 2013]
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 UniProt Comments for Wt1    Transcription factor that plays an important role in cellular development and cell survival (PubMed:16467207, PubMed:16920711, PubMed:17537799). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (). Regulates the expression of numerous target genes, including EPO (PubMed:16467207). Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:17167543). Isoform 1 has lower affinity for DNA, and can bind RNA.
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 Research Articles on Wt1    1. both the local oxygen environment and WT1, which enhances KDR expression, contribute to sex-specific Sox9 expression in developing murine gonads
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Wt1 recombinant proteinDiseases associated with Wt1 recombinant protein
 Products by Pathway  Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1641 publications with Wt1 and Neoplasms
 Wilms Tumor Antibodies  >1554 publications with Wt1 and Wilms Tumor
 Kidney Diseases Antibodies  >769 publications with Wt1 and Kidney Diseases
 Leukemia, Myeloid Antibodies  >378 publications with Wt1 and Leukemia, Myeloid
 Leukemia, Myeloid, Acute Antibodies  >315 publications with Wt1 and Leukemia, Myeloid, Acute
 Carcinoma Antibodies  >291 publications with Wt1 and Carcinoma
 Chromosome Aberrations Antibodies  >179 publications with Wt1 and Chromosome Aberrations
 Denys-Drash Syndrome Antibodies  >173 publications with Wt1 and Denys-Drash Syndrome
 Hematologic Diseases Antibodies  >165 publications with Wt1 and Hematologic Diseases
 Adenocarcinoma Antibodies  >156 publications with Wt1 and Adenocarcinoma
Organs/Tissues associated with Wt1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >830 publications with Wt1 and Kidney
 Blood Antibodies  >456 publications with Wt1 and Blood
 Testis Antibodies  >135 publications with Wt1 and Testis
 Embryonic Tissue Antibodies  >123 publications with Wt1 and Embryonic Tissue
 Lung Antibodies  >118 publications with Wt1 and Lung
 Ovary Antibodies  >112 publications with Wt1 and Ovary
 Heart Antibodies  >77 publications with Wt1 and Heart
 Brain Antibodies  >76 publications with Wt1 and Brain
 Uterus Antibodies  >42 publications with Wt1 and Uterus
 Pancreas Antibodies  >11 publications with Wt1 and Pancreas
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