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WASP recombinant protein :: Wiskott Aldrich Syndrome Protein Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2033079 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
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Unit / Price
0.01 mg  /  $135 +1 FREE 8GB USB
0.05 mg  /  $250 +1 FREE 8GB USB
0.1 mg  /  $385 +1 FREE 8GB USB
0.2 mg  /  $470 +1 FREE 8GB USB
0.5 mg  /  $910 +1 FREE 8GB USB
1 mg  /  $1,345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Wiskott Aldrich Syndrome Protein (WASP), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Wiskott Aldrich Syndrome Protein (WASP)

 Product Synonym Names    WAS; IMD2; THC; Eczema-Thrombocytopenia
 Product Gene Name   

WASP recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    LG RKCLTLATAV VQLYLALPPG AEHWTKEHCG AVCFVKDNPQ KSYFIRLYGL QAGRLLWEQE LYSQLVYSTP TPFFHTFAGD DCQAGLNFAD EDEAQAFRAL VQEKIQKRNQ RQSGDRRQLP PPPTPANEER RGGLPPLPLH PGGDQGGPPV GPLSLGLATV DIQNPDITSS RYRGLPAPGP SPADKKRSGK KKISKADIGA PSGFKHVSHV G
 OMIM    300299
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 Host    E Coli
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 Purity/Purification    > 90%
 Form/Format    Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
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 Predicted Molecular Mass    26.9kDa
 Usage    Reconstitute in sterile PBS, pH7.2-pH7.4.
 Endotoxin Level    <1.0EU per 1 ug (determined by the LAL method)
 Expression System    Prokaryotic expression
 Fragment    Leu39~Gly251
 Organism Species    Human
 Tag    two N-terminal Tags, His-tag and T7-tag
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 Preparation and Storage    Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of WASP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for WASP recombinant protein   

SDS-PAGE, Western (WB), ELISA (EIA), Immunoprecipitation (IP).

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 SDS-Page of WASP recombinant protein    WASP recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for WASP. It may not necessarily be applicable to this product.
 NCBI GI #    4507909
 NCBI GeneID    7454
 NCBI Accession #    NP_000368.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000377.2 [Other Products]
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 UniProt Secondary Accession #    Q9BU11; Q9UNJ9 [Other Products]
 UniProt Related Accession #    P42768 [Other Products]
 Molecular Weight    52,913 Da
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 NCBI Official Full Name    wiskott-Aldrich syndrome protein
 NCBI Official Synonym Full Names    Wiskott-Aldrich syndrome
 NCBI Official Symbol    WAS [Similar Products]
 NCBI Official Synonym Symbols   
THC; IMD2; SCNX; THC1; WASP; WASPA
[Similar Products]
 NCBI Protein Information    wiskott-Aldrich syndrome protein
 UniProt Protein Name    Wiskott-Aldrich syndrome protein
 UniProt Gene Name    WAS [Similar Products]
 UniProt Synonym Gene Names    IMD2; WASp [Similar Products]
 UniProt Entry Name    WASP_HUMAN
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 NCBI Summary for WASP    The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known. [provided by RefSeq, Jul 2008]
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 UniProt Comments for WASP    WASP: a member of the Wiskott-Aldrich syndrome (WAS) family of proteins. A cytoplasmic protein expressed exclusively in hematopoietic cells. Transduces signals from surface receptors to the actin cytoskeleton. Associates with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Mutated in Wiskott-Aldrich syndrome, a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: Xp11.4-p11.21

Cellular Component: actin cytoskeleton; cytosol; intercellular junction; vesicle membrane

Molecular Function: actin binding; GTPase regulator activity; identical protein binding; phospholipase binding; protein binding; protein kinase binding; SH3 domain binding

Biological Process: actin filament polymerization; actin filament-based movement; actin polymerization and/or depolymerization; blood coagulation; defense response; endosome transport; epidermis development; immune response; innate immune response; protein complex assembly; regulation of catalytic activity; regulation of T cell antigen processing and presentation; small GTPase mediated signal transduction; T cell activation; T cell receptor signaling pathway

Disease: Neutropenia, Severe Congenital, X-linked; Thrombocytopenia 1
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 Research Articles on WASP    1. The introduction of functional WASp by GT corrected the alterations of both central and peripheral B cell tolerance checkpoints. WASp plays an important role in the establishment and maintenance of B cell tolerance in humans.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with WASP recombinant protein
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Choline Metabolism In Cancer Pathway antibodies  Choline Metabolism In Cancer Pathway Diagram
 Choline Metabolism In Cancer Pathway antibodies  Choline Metabolism In Cancer Pathway Diagram
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