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Wnt-3a recombinant protein

Scan QR to view Datasheet Catalog #    MBS9422044 Wnt-3a recombinant protein
Unit / Price
0.01 mg  /  $180 +1 FREE 8GB USB
0.05 mg  /  $225 +1 FREE 8GB USB
0.1 mg  /  $320 +1 FREE 8GB USB
0.2 mg  /  $500 +1 FREE 8GB USB
0.5 mg  /  $800 +1 FREE 8GB USB
1 mg  /  $1,235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Wnt-3a, Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Protein Wnt-3a

 Product Synonym Names    WNT3A
 Product Gene Name   

Wnt-3a recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    Partial of the Full Length of 19-352aa, 19-351aa
 Sequence    SYPIWWSLAV GPQYSSLGSQ PILCASIPGL VPKQLRFCRN YVEIMPSVAE GIKIGIQECQ HQFRGRRWNC TTVHDSLAIF GPVLDKATRE SAFVHAIASA GVAFAVTRSC AEGTAAICGC SSRHQGSPGK GWKWGGCSED IEFGGMVSRE FADARENRPD ARSAMNRHNN EAGRQAIASH MHLKCKCHGL SGSCEVKTCW WSQPDFRAIG DFLKDKYDSA SEMVVEKHRE SRGWVETLRP RYTYFKVPTE RDLVYYEASP NFCEPNPETG SFGTRDRTCN VSSHGIDGCD LLCCGRGHNA RAERRREKCR CVFHWCCYVS CQECTRVYDV HTC
 OMIM    AB060284 mRNA
 3D Structure    ModBase 3D Structure for P56704
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 Host    E Coli
 Species Reactivity    Human
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE.
 Form/Format    Tri-based buffer 50% glycerol.
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 Tag Info    N-Terminal 6xHis-tagged
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 Preparation and Storage    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.

Generally, the shelf life of liquid form is 6 months at -20C,-80C. The shelf life of lyophilized form is 12 months at -20C,-80C.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
 Other Notes    Small volumes of Wnt-3a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Wnt-3a recombinant protein

   Ligand for mbers of the frizzled family of seven transmbrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube.
NCBI/Uniprot data below describe general gene information for Wnt-3a. It may not necessarily be applicable to this product.
 NCBI GI #    14916475
 NCBI GeneID    89780
 NCBI Accession #    NP_149122.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_033131.3 [Other Products]
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 UniProt Primary Accession #    P56704 [Other Products]
 UniProt Secondary Accession #    Q3SY79; Q3SY80; Q969P2 [Other Products]
 UniProt Related Accession #    P56704 [Other Products]
 Molecular Weight    41.3kD
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 NCBI Official Full Name    protein Wnt-3a
 NCBI Official Synonym Full Names    Wnt family member 3A
 NCBI Official Symbol    WNT3A [Similar Products]
 NCBI Protein Information    protein Wnt-3a
 UniProt Protein Name    Protein Wnt-3a
 Protein Family    Protein
 UniProt Gene Name    WNT3A [Similar Products]
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 NCBI Summary for Wnt-3a    The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. [provided by RefSeq, Jul 2008]
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 UniProt Comments for Wnt-3a    WNT3A: Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube. Interacts with PORCN. Interacts with APCDD1 and WLS. Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly in the complex with LRP6. Moderately expressed in placenta and at low levels in adult lung, spleen, and prostate. Belongs to the Wnt family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q42.13

Cellular Component: cell surface; early endosome membrane; endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi lumen; plasma membrane

Molecular Function: frizzled binding; protein binding; receptor agonist activity; receptor binding; transcription coactivator activity

Biological Process: cell proliferation in forebrain; cell proliferation in midbrain; negative regulation of neurogenesis; neuron differentiation; palate development; positive regulation of cell proliferation; positive regulation of mesodermal cell fate specification; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of protein binding; positive regulation of receptor internalization; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; signalosome assembly; Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin
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 Research Articles on Wnt-3a    1. Taken together, our results suggest that canonical Wnt signaling and its antagonist, sFRP1, regulate proliferation of human CSCs. Furthermore, excess sFRP1 in elderly patients causes CSC aging.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Wnt-3a recombinant proteinPathways associated with Wnt-3a recombinant protein
 Reference Product  PubMed Publications
 CTNNB1 recombinant protein  >739 publications with Wnt-3a and CTNNB1
 DKK1 recombinant protein  >130 publications with Wnt-3a and DKK1
 LRP6 recombinant protein  >100 publications with Wnt-3a and LRP6
 FZD1 recombinant protein  >20 publications with Wnt-3a and FZD1
 DVL2 recombinant protein  >17 publications with Wnt-3a and DVL2
 AXIN1 recombinant protein  >14 publications with Wnt-3a and AXIN1
 DVL3 recombinant protein  >12 publications with Wnt-3a and DVL3
 FZD8 recombinant protein  >8 publications with Wnt-3a and FZD8
 WIF1 recombinant protein  >7 publications with Wnt-3a and WIF1
 DVL1 recombinant protein  >5 publications with Wnt-3a and DVL1
 Products by Pathway  Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Canonical Wnt Signaling Pathway antibodies  Canonical Wnt Signaling Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
Diseases associated with Wnt-3a recombinant proteinOrgans/Tissues associated with Wnt-3a recombinant protein
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >37 publications with Wnt-3a and Breast Neoplasms
 Necrosis Antibodies  >29 publications with Wnt-3a and Necrosis
 Inflammation Antibodies  >28 publications with Wnt-3a and Inflammation
 Fibrosis Antibodies  >27 publications with Wnt-3a and Fibrosis
 Congenital Abnormalities Antibodies  >26 publications with Wnt-3a and Congenital Abnormalities
 Liver Diseases Antibodies  >22 publications with Wnt-3a and Liver Diseases
 Lung Diseases Antibodies  >18 publications with Wnt-3a and Lung Diseases
 Liver Neoplasms Antibodies  >17 publications with Wnt-3a and Liver Neoplasms
 Brain Diseases Antibodies  >17 publications with Wnt-3a and Brain Diseases
 Neoplasms, Experimental Antibodies  >14 publications with Wnt-3a and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >56 publications with Wnt-3a and Connective Tissue
 Lung Antibodies  >39 publications with Wnt-3a and Lung
 Placenta Antibodies  >11 publications with Wnt-3a and Placenta
 Testis Antibodies  >6 publications with Wnt-3a and Testis
 Trachea Antibodies  >2 publications with Wnt-3a and Trachea
 Uncharacterized Tissue Antibodies  >1 publications with Wnt-3a and Uncharacterized Tissue
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