Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow WNT4  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Retinol Binding Protein 1, Cellular (RBP1) ELISA Kit
 • TERF1 Antibody
 • SOX10 Antibody
 • Cathepsin K (CTSK) Recombinant Protein
 • Toll-like receptor 2 (TLR2) Antibody
 • ATP1B1 Antibody
 • S- (hydroxymethyl)glutathione dehydrogenase (SFA1) Recombinant Protein
 • Plasminogen Activator Inhibitor 1 (PAI 1) ELISA Kit
 • Goat F(ab')2 Anti-Human IgA (alpha chain specific) Secondary Antibody
 • Muscle, skeletal receptor tyrosine-protein kinase (MUSK) Recombinant Protein
 • LRRC8E Antibody
 • Erbin (ERBB2IP) Antibody
 • V5-TAG Antibody
 • Fowl Pox Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

WNT4 recombinant protein :: Wnt-4 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS964633
SDS-Page
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $860 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $995 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,155 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,240 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,260 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,305 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,815 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,880 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,985 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,415 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Wnt-4 (WNT4), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Protein Wnt-4

 Product Gene Name   

WNT4 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence Positions    23-351aa; Full Length
 Sequence    SNWLYLAKLS SVGSISEEET CEKLKGLIQR QVQMCKRNLE VMDSVRRGAQ LAIEECQYQF RNRRWNCSTL DSLPVFGKVV TQGTREAAFV YAISSAGVAF AVTRACSSGE LEKCGCDRTV HGVSPQGFQW SGCSDNIAYG VAFSQSFVDV RERSKGASSS RALMNLHNNE AGRKAILTHM RVECKCHGVS GSCEVKTCWR AVPPFRQVGH ALKEKFDGAT EVEPRRVGSS RALVPRNAQF KPHTDEDLVY LEPSPDFCEQ DMRSGVLGTR GRTCNKTSKA IDGCELLCCG RGFHTAQVEL AERCSCKFHW CCFVKCRQCQ RLVELHTCR
 OMIM    158330
 3D Structure    ModBase 3D Structure for P56705
Section Bar
 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
Section Bar
 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
Section Bar
Section Bar
 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of WNT4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for WNT4 recombinant protein

   Ligand for mbers of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Overexpression may be associated with abnormal proliferation in human breast tissue.
 Product Categories/Family for WNT4 recombinant protein    Signal Transduction
Section Bar
 SDS-Page of WNT4 recombinant protein    WNT4 recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for WNT4. It may not necessarily be applicable to this product.
 NCBI GI #    17402922
 NCBI GeneID    54361
 NCBI Accession #    NP_110388.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_030761.4 [Other Products]
Section Bar
 UniProt Primary Accession #    P56705 [Other Products]
 UniProt Secondary Accession #    Q5TZQ0; Q96T81; Q9BXF5; Q9H1J8; Q9UJM2; B4DJF9 [Other Products]
 UniProt Related Accession #    P56705 [Other Products]
 Molecular Weight    52.65kD
Table BarTOPTable Bar
 NCBI Official Full Name    protein Wnt-4
 NCBI Official Synonym Full Names    wingless-type MMTV integration site family member 4
 NCBI Official Symbol    WNT4 [Similar Products]
 NCBI Official Synonym Symbols   
WNT-4; SERKAL
[Similar Products]
 NCBI Protein Information    protein Wnt-4
 UniProt Protein Name    Protein Wnt-4
 UniProt Gene Name    WNT4 [Similar Products]
 UniProt Entry Name    WNT4_HUMAN
Section Bar
 NCBI Summary for WNT4    The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for WNT4    WNT4: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Overexpression may be associated with abnormal proliferation in human breast tissue. Defects in WNT4 are a cause of Rokitansky-Kuster-Hauser syndrome (RKH syndrome); also called Mayer- Rokitansky-Kuster-Hauser syndrome (MRKH syndrome or MRKH anomaly). RKH syndrome is characterized by utero-vaginal atresia in otherwise phenotypically normal female with a normal 46,XX karyotype. Anomalies of the genital tract range from upper vaginal atresia to total Muellerian agenesis with urinary tract abnormalities. It has an incidence of approximately 1 in 5'000 newborn girls. Defects in WNT4 are the cause of female sex reversal with dysgenesis of kidneys, adrenals, and lungs (SERKAL); also known as SERKAL syndrome. Defects in WNT4 are the cause of Muellerian aplasia (MULLAPL). Belongs to the Wnt family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p36.23-p35.1

Cellular Component: cell surface; cytoplasm; endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi lumen; plasma membrane; proteinaceous extracellular matrix

Molecular Function: frizzled binding; receptor agonist activity; transcription corepressor activity

Biological Process: adrenal gland development; androgen biosynthetic process; cell fate commitment; cellular response to starvation; embryonic epithelial tube formation; epithelial to mesenchymal transition; female gonad development; female sex determination; immature T cell proliferation in the thymus; kidney development; liver development; male gonad development; negative regulation of cell differentiation; negative regulation of cell migration; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of transcription, DNA-dependent; neuron differentiation; oocyte development; positive regulation of aldosterone biosynthetic process; positive regulation of bone mineralization; positive regulation of collagen biosynthetic process; positive regulation of focal adhesion formation; positive regulation of GTPase activity; positive regulation of meiosis; positive regulation of osteoblast differentiation; positive regulation of stress fiber formation; positive regulation of transcription, DNA-dependent; regulation of cell-cell adhesion; smooth muscle cell differentiation; somatotropin secreting cell differentiation; thyroid stimulating hormone secreting cell differentiation; ureteric bud branching; Wnt receptor signaling pathway through beta-catenin

Disease: 46,xx Sex Reversal With Dysgenesis Of Kidneys, Adrenals, And Lungs; Mullerian Aplasia And Hyperandrogenism
Table BarTOPTable Bar
 

Product References and Citations for WNT4 recombinant protein

   Molecular cloning and characterization of six novel human WNT genes.Testa T.T., Mossakowska D.E., Carter P.S., Hu E., Zhu Y., Kelsell D.P., Murdock P.R., Herrity N.C., Lewis C.J., Cross D.A., Culbert A.A., Reith A.D., Barnes M.R.Up-regulation of wnt-4 signaling and dosage-sensitive sex reversal in humans.Jordan B.K., Mohammed M., Ching S.T., Delot E., Chen X.N., Dewing P., Swain A., Rao P.N., Elejalde B.R., Vilain E.Am. J. Hum. Genet. 68:1102-1109(2001)
Section Bar
 Research Articles on WNT4    1. The results demonstrated that WNT4 rs2235529 is associated with endometriosis in Chinese Han women, which may result in aberrant expression of WNT4, leading to the pathogenesis of endometriosis.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with WNT4 recombinant proteinPathways associated with WNT4 recombinant protein
 Reference Product  PubMed Publications
 FZD1 recombinant protein  >19 publications with WNT4 and FZD1
 BMP4 recombinant protein  >18 publications with WNT4 and BMP4
 SFRP1 recombinant protein  >14 publications with WNT4 and SFRP1
 FZD2 recombinant protein  >13 publications with WNT4 and FZD2
 SFRP2 recombinant protein  >13 publications with WNT4 and SFRP2
 LRP6 recombinant protein  >12 publications with WNT4 and LRP6
 FZD6 recombinant protein  >9 publications with WNT4 and FZD6
 FZD3 recombinant protein  >8 publications with WNT4 and FZD3
 WIF1 recombinant protein  >5 publications with WNT4 and WIF1
 WLS recombinant protein  >1 publications with WNT4 and WLS
 Products by Pathway  Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Beta-catenin Independent WNT Signaling Pathway antibodies  Beta-catenin Independent WNT Signaling Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
Diseases associated with WNT4 recombinant proteinOrgans/Tissues associated with WNT4 recombinant protein
 Disease Name  Pubmed Publications
 Female Urogenital Diseases Antibodies  >95 publications with WNT4 and Female Urogenital Diseases
 Disease Models, Animal Antibodies  >24 publications with WNT4 and Disease Models, Animal
 Kidney Diseases Antibodies  >23 publications with WNT4 and Kidney Diseases
 Fibrosis Antibodies  >19 publications with WNT4 and Fibrosis
 MAYER-ROKITANSKY-KUSTER-HAUSER SYNDROME Antibodies  >16 publications with WNT4 and MAYER-ROKITANSKY-KUSTER-HAUSER SYNDROME
 Inflammation Antibodies  >12 publications with WNT4 and Inflammation
 Breast Neoplasms Antibodies  >12 publications with WNT4 and Breast Neoplasms
 Hypertension Antibodies  >9 publications with WNT4 and Hypertension
 Infertility, Male Antibodies  >9 publications with WNT4 and Infertility, Male
 Liver Diseases Antibodies  >7 publications with WNT4 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >113 publications with WNT4 and Kidney
 Ovary Antibodies  >99 publications with WNT4 and Ovary
 Embryonic Tissue Antibodies  >87 publications with WNT4 and Embryonic Tissue
 Uterus Antibodies  >52 publications with WNT4 and Uterus
 Brain Antibodies  >34 publications with WNT4 and Brain
 Mammary Gland Antibodies  >28 publications with WNT4 and Mammary Gland
 Eye Antibodies  >19 publications with WNT4 and Eye
 Heart Antibodies  >13 publications with WNT4 and Heart
 Lung Antibodies  >12 publications with WNT4 and Lung
 Placenta Antibodies  >7 publications with WNT4 and Placenta
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions