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| Product Name
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Wnt3a, Recombinant Protein
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| Also Known As
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Wnt3a protein (Mouse)
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| Product Synonym Names
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Wnta-3 protein; wingless-type MMTV integration site family protein; Wnta 3 protein; WNT member 3A protein
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| Sequence
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AA sequence (19-352): SYPIWWSLAV GPQYSSLSTQ PILCASIPGL VPKQLRFCRN YVEIMPSVAE GVKAGIQECQ HQFRGRRWN CTTVSNSLAI FGPVLDKATR ESAFVHAIAS AGVAFAVTRS CAEGSAAICG C SSRLQGSPGE GWKWGGCS EDIEFGGMVS REFADARENR PDARSAMNRH NNEAGRQAIA SH MHLKCKCHGL SGSCEVKTCW WSQPDFR TIGDFLKDKY DSASEMVVEK HRESRGWVET LRP RYTYFKVPTE RDLVYYEASP NFCEPNPETG SFGTRD RTCNVSSHGI DGCDLLCCGR GHNA RTERRREKCH CVFHWCCYVS CQECTRVYDV HTCK
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| OMIM
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606359
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| Host
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E. Coli
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| Purity/Purification
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> 90% by SDS-PAGE
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| Form/Format
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Liquid in 20mM Tris-HCl, pH8.0 with 500mM Arg and 50% glycerol.
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| Concentration
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0.125 mg/ml (lot specific)
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| Protein Type
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Recombinant
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| Biological Significance
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Wnt3ais a ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube.
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| Biohazard
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Use standard laboratory precautions when handling this material.
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| Preparation and Storage
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4 degree C shipping only. Upon receipt store at -20 degree C to -80 degree C. Avoid repeat freeze-thaw cycles.
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| Other Notes
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Small volumes of Wnt3a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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TOP
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Purified recombinant Wnt3a protein (Mouse)
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| Product Categories/Family for Wnt3a recombinant protein
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Signal Transduction
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| NCBI/Uniprot data below describe general gene information for Wnt3a. It may not necessarily be applicable to this product. |
| NCBI GI #
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14530679
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| NCBI GeneID
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89780
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| NCBI Accession #
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BAB61052.1
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[Other Products]
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| UniProt Secondary Accession #
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Q3SY79; Q3SY80; Q969P2
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[Other Products]
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| UniProt Related Accession #
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P56704
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[Other Products]
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| Molecular Weight
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42,905 Da
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TOP
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| NCBI Official Full Name
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WNT3A
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| NCBI Official Synonym Full Names
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wingless-type MMTV integration site family, member 3A
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| NCBI Official Symbol
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WNT3A
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[Similar Products]
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| NCBI Protein Information
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protein Wnt-3a
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| UniProt Protein Name
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Protein Wnt-3a
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| UniProt Gene Name
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WNT3A
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[Similar Products]
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| UniProt Entry Name
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WNT3A_HUMAN
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| NCBI Summary for Wnt3a
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The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. [provided by RefSeq, Jul 2008]
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| UniProt Comments for Wnt3a
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WNT3A: Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube. Interacts with PORCN. Interacts with APCDD1 and WLS. Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly in the complex with LRP6. Moderately expressed in placenta and at low levels in adult lung, spleen, and prostate. Belongs to the Wnt family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1q42
Cellular Component: extracellular space; proteinaceous extracellular matrix; cell surface; Golgi lumen; early endosome membrane; endoplasmic reticulum lumen; extracellular region; plasma membrane
Molecular Function: protein domain specific binding; protein binding; frizzled binding; transcription coactivator activity; receptor agonist activity; frizzled-2 binding
Biological Process: positive regulation of mesodermal cell fate specification; axon guidance; extracellular matrix organization and biogenesis; positive regulation of protein binding; cell proliferation in forebrain; positive regulation of transcription, DNA-dependent; positive regulation of receptor internalization; positive regulation of caspase activity; Wnt receptor signaling pathway through beta-catenin; positive regulation of collateral sprouting in the absence of injury; palate development; negative regulation of axon extension involved in axon guidance; Wnt receptor signaling pathway in forebrain neuroblast division; negative regulation of neurogenesis; neuron differentiation; mammary gland development; positive regulation of cell proliferation; positive regulation of B cell proliferation; hemopoiesis; heart looping; dorsoventral neural tube patterning; inner ear morphogenesis; in utero embryonic development; hippocampus development; negative regulation of fat cell differentiation; positive regulation of peptidyl-serine phosphorylation; osteoblast differentiation; paraxial mesodermal cell fate commitment; signalosome assembly; spinal cord association neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; positive regulation of protein amino acid phosphorylation
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TOP
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| Research Articles on Wnt3a
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1. miR-195 is key in regulating cell proliferation, cell cycle and apoptosis through targeting Wnt3a.
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TOP
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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| Products associated with Wnt3a recombinant protein | Pathways associated with Wnt3a recombinant protein |
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| Diseases associated with Wnt3a recombinant protein | Organs/Tissues associated with Wnt3a recombinant protein |
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TOP
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Recombinant Protein 
