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WFS1 recombinant protein :: Wolframin (WFS1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1039162 WFS1 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $615 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $765 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $825 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $910 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $910 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,025 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,150 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,150 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,160 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,285 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,660 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,750 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,760 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,215 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Wolframin (WFS1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Wolframin (WFS1)

 Product Synonym Names    Recombinant Wolframin (WFS1); Wolframin
 Product Gene Name   

WFS1 recombinant protein

[Similar Products]
 Product Synonym Gene Name    WFS1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    653-869. Partial.
 Sequence    RSEGMKVYNS TLTWQQYGAL CGPRAWKETN MARTQILCSH LEGHRVTWTG RFKYVRVTDI DNSAESAINM LPFFIGDWMR CLYGEAYPAC SPGNTSTAEE ELCRLKLLAK HPCHIKKFDR YKFEITVGMP FSSGADGSRS REEDDVTKDI VLRASSEFKS VLLSLRQGSL IEFSTILEGR LGSKWPVFEL KAISCLNCMA QLSPTRRHVK IEHDWRS
 Chromosome Location    Chromosome: 4; NC_000004.11 (6271577..6304992). Location: 4p16.1
 OMIM    222300
 3D Structure    ModBase 3D Structure for O76024
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of WFS1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for WFS1. It may not necessarily be applicable to this product.
 NCBI GI #    224994205
 NCBI GeneID    7466
 NCBI Accession #    NP_001139325.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001145853.1 [Other Products]
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 UniProt Primary Accession #    O76024 [Other Products]
 UniProt Secondary Accession #    Q8N6I3; Q9UNW6; B2R797; D3DVT1 [Other Products]
 UniProt Related Accession #    O76024 [Other Products]
 Molecular Weight    100,292 Da [Similar Products]
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 NCBI Official Full Name    wolframin
 NCBI Official Synonym Full Names    Wolfram syndrome 1 (wolframin)
 NCBI Official Symbol    WFS1 [Similar Products]
 NCBI Official Synonym Symbols   
WFS; WFRS; WFSL
[Similar Products]
 NCBI Protein Information    wolframin
 UniProt Protein Name    Wolframin
 Protein Family    Wolframin
 UniProt Gene Name    WFS1 [Similar Products]
 UniProt Entry Name    WFS1_HUMAN
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 NCBI Summary for WFS1    This gene encodes a transmembrane protein, which is located primarily in the endoplasmic reticulum and ubiquitously expressed with highest levels in brain, pancreas, heart, and insulinoma beta-cell lines. Mutations in this gene are associated with Wolfram syndrome, also called DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness), an autosomal recessive disorder. The disease affects the brain and central nervous system. Mutations in this gene can also cause autosomal dominant deafness 6 (DFNA6), also known as DFNA14 or DFNA38. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
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 UniProt Comments for WFS1    WFS1: Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store. Highly expressed in heart followed by brain, placenta, lung and pancreas. Weakly expressed in liver, kidney and skeletal muscle. Also expressed in islet and beta-cell insulinoma cell line.

Protein type: Endoplasmic reticulum; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4p16.1

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; dendrite; integral to endoplasmic reticulum membrane

Molecular Function: calmodulin binding; transcription activator binding; transporter activity; ubiquitin protein ligase binding; calcium-dependent protein binding; ATPase binding

Biological Process: ER-associated protein catabolic process; protein maturation via protein folding; protein stabilization; olfactory behavior; positive regulation of proteolysis; unfolded protein response; negative regulation of transcription factor activity; glucose homeostasis; positive regulation of protein metabolic process; neurological system process; calcium ion homeostasis; endoplasmic reticulum calcium ion homeostasis; sensory perception of sound; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; visual perception; positive regulation of protein ubiquitination; negative regulation of programmed cell death; renal water homeostasis; negative regulation of neuron apoptosis; kidney development; positive regulation of calcium ion transport; positive regulation of growth; ER overload response

Disease: Deafness, Autosomal Dominant 6; Wolfram Syndrome 1; Wolfram-like Syndrome, Autosomal Dominant; Cataract 41; Diabetes Mellitus, Noninsulin-dependent
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 Research Articles on WFS1    1. Cataract could be a marker for the WFS1 heterozygosity in this family, namely the c.2431_2465dup35 mutation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with WFS1 recombinant proteinDiseases associated with WFS1 recombinant protein
 Products by Pathway  Pathway Diagram
 Activation Of Chaperone Genes By XBP1(S) Pathway antibodies  Activation Of Chaperone Genes By XBP1(S) Pathway Diagram
 Activation Of Chaperones By IRE1alpha Pathway antibodies  Activation Of Chaperones By IRE1alpha Pathway Diagram
 Diabetes Pathways antibodies  Diabetes Pathways Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Unfolded Protein Response Pathway antibodies  Unfolded Protein Response Pathway Diagram
 Disease Name  Pubmed Publications
 Wolfram Syndrome Antibodies  >134 publications with WFS1 and Wolfram Syndrome
 Nervous System Diseases Antibodies  >112 publications with WFS1 and Nervous System Diseases
 Kidney Diseases Antibodies  >88 publications with WFS1 and Kidney Diseases
 Pituitary Diseases Antibodies  >87 publications with WFS1 and Pituitary Diseases
 Atrophy Antibodies  >77 publications with WFS1 and Atrophy
 Diabetes Mellitus, Type 2 Antibodies  >38 publications with WFS1 and Diabetes Mellitus, Type 2
 Mood Disorders Antibodies  >13 publications with WFS1 and Mood Disorders
 Insulin Resistance Antibodies  >11 publications with WFS1 and Insulin Resistance
 Glucose Intolerance Antibodies  >7 publications with WFS1 and Glucose Intolerance
 Obesity Antibodies  >7 publications with WFS1 and Obesity
Organs/Tissues associated with WFS1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >30 publications with WFS1 and Pancreas
 Brain Antibodies  >27 publications with WFS1 and Brain
 Nerve Antibodies  >14 publications with WFS1 and Nerve
 Liver Antibodies  >5 publications with WFS1 and Liver
 Bone Antibodies  >5 publications with WFS1 and Bone
 Kidney Antibodies  >3 publications with WFS1 and Kidney
 Eye Antibodies  >3 publications with WFS1 and Eye
 Connective Tissue Antibodies  >2 publications with WFS1 and Connective Tissue
 Skin Antibodies  >1 publications with WFS1 and Skin
 Ovary Antibodies  >1 publications with WFS1 and Ovary
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