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XIAP recombinant protein :: X-Linked Inhibitor Of Apoptosis Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2031583 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
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Unit / Price
0.01 mg  /  $145 +1 FREE 8GB USB
0.05 mg  /  $270 +1 FREE 8GB USB
0.1 mg  /  $420 +1 FREE 8GB USB
0.2 mg  /  $515 +1 FREE 8GB USB
0.5 mg  /  $995 +1 FREE 8GB USB
1 mg  /  $1,480 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

X-Linked Inhibitor Of Apoptosis (XIAP), Recombinant Protein

 Also Known As   

Recombinant X-Linked Inhibitor Of Apoptosis Protein (XIAP)

 Product Gene Name   

XIAP recombinant protein

[Similar Products]
 Matching Pairs    Antibody: Inhibitor Of Apoptosis (MBS2028046)
Antigen: X-Linked Inhibitor Of Apoptosis (MBS2031583)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with two N-terminal Tags, His-tag and T7-tag, its sequence is listed below.
MTFNSFEGS K TCVPADINKE EEFVEEFNRL KTFANFPSGS PVSASTLARA GFLYTGEGDT VRCFSCHAAV DRWQYGDSAV GRHRKVSPNC RFINGFYLEN SATQSTNSGI QNGQYKVENY LGSRDHFALD RPSETHADYL LRTGQVVDIS DTIYPRNPAM YSEEARLKSF QNWPDYAHLT PRELASAGLY YTGIGDQVQC FCCGGKLKNW EPCDRAWSEH RRHFPNCFFV LGRNLNIRSE SDAVSSDRNF PNSTNLPRNP SMADYEARIF TFGTWIYSVN KEQLARAGFY ALGEGDKVKC FHCGGGLTDW KPSEDPWEQH AKWYPGCKYL LEQKGQEYIN NIHLTHSLEE CLVRTTEKTP SLTRRIDDTI FQNPMVQEAI RMGFSFKDIK KIMEEKIQIS GSNYKSLEVL VADLVNAQKD SMQDESSQTS LQKEISTEEQ LRRLQEEKLC KICMDRNIAI VFVPCGHLVT CKQCAEAVDK CPMCYTVITF KQKIFMS
 OMIM    300079
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 Host    Host: E Coli
Source: Prokaryotic expression
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 Purity/Purification    >90%
 Form/Format    Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
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 Predicted Molecular Mass    60.4kDa
 Accurate Molecular Mass (KD)    60kDa
 Endotoxin    <1.0EU per 1ug (determined by the LAL method)
 Expression System    Prokaryotic expression
 Tag    N-terminal His-Tag
 Organism Species    Homo sapiens (Human)
 Fragment    Met1~Ser497
 Usage    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of XIAP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for XIAP recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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 SDS-Page of XIAP recombinant protein    XIAP recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for XIAP. It may not necessarily be applicable to this product.
 NCBI GI #    21619764
 NCBI GeneID    331
 NCBI Accession #    AAH32729.1 [Other Products]
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 UniProt Secondary Accession #    Q9NQ14; D3DTF2 [Other Products]
 UniProt Related Accession #    P98170 [Other Products]
 Molecular Weight    56,685 Da
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 NCBI Official Full Name    X-linked inhibitor of apoptosis
 NCBI Official Synonym Full Names    X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
 NCBI Official Symbol    XIAP [Similar Products]
 NCBI Official Synonym Symbols   
API3; ILP1; MIHA; XLP2; BIRC4; IAP-3; hIAP3; hIAP-3
[Similar Products]
 NCBI Protein Information    E3 ubiquitin-protein ligase XIAP
 UniProt Protein Name    E3 ubiquitin-protein ligase XIAP
 UniProt Synonym Protein Names   
Baculoviral IAP repeat-containing protein 4; IAP-like protein; ILP; hILP; Inhibitor of apoptosis protein 3; IAP-3; hIAP-3; hIAP3; X-linked inhibitor of apoptosis protein; X-linked IAP
 Protein Family    E3 ubiquitin-protein ligase
 UniProt Gene Name    XIAP [Similar Products]
 UniProt Synonym Gene Names    API3; BIRC4; IAP3; ILP; hILP; IAP-3; hIAP-3; hIAP3; X-linked IAP [Similar Products]
 UniProt Entry Name    XIAP_HUMAN
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 NCBI Summary for XIAP    This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]
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 UniProt Comments for XIAP    XIAP: an apoptotic suppressor protein. Inhibist apoptosis through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2. Inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. Inhibits cell-death proteases, caspase-3, caspase-7, and perhaps caspase-9.

Protein type: Ubiquitin conjugating system; Ligase; EC 6.3.2.-; Ubiquitin ligase; Apoptosis

Chromosomal Location of Human Ortholog: Xq25

Cellular Component: nucleoplasm; spindle microtubule; cytoplasm; cytosol; nucleus

Molecular Function: protein binding; zinc ion binding; caspase inhibitor activity; ubiquitin-protein ligase activity; ligase activity

Biological Process: Wnt receptor signaling pathway; apoptosis; positive regulation of protein ubiquitination; regulation of BMP signaling pathway; regulation of inflammatory response; protein ubiquitination; negative regulation of caspase activity; response to DNA damage stimulus; copper ion homeostasis; regulation of cell proliferation; negative regulation of apoptosis; regulation of innate immune response

Disease: Lymphoproliferative Syndrome, X-linked, 1; Lymphoproliferative Syndrome, X-linked, 2
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 Research Articles on XIAP    1. Patients carrying the Glu349del mutation in the XIAP gene may have a clinically and immunologically distinct phenotype from patients with other XIAP mutations. The Glu349del mutation may be associated with dysgammaglobulinemia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with XIAP recombinant proteinPathways associated with XIAP recombinant protein
 Reference Product  PubMed Publications
 CASP3 recombinant protein  >893 publications with XIAP and CASP3
 CASP9 recombinant protein  >431 publications with XIAP and CASP9
 DIABLO recombinant protein  >317 publications with XIAP and DIABLO
 CASP7 recombinant protein  >82 publications with XIAP and CASP7
 HTRA2 recombinant protein  >79 publications with XIAP and HTRA2
 APAF1 recombinant protein  >61 publications with XIAP and APAF1
 TAB1 recombinant protein  >12 publications with XIAP and TAB1
 UBC recombinant protein  >3 publications with XIAP and UBC
 UBE2D1 recombinant protein  >1 publications with XIAP and UBE2D1
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Factor-mediated Response Pathway antibodies  Apoptotic Factor-mediated Response Pathway Diagram
 BMP Receptor Signaling Pathway antibodies  BMP Receptor Signaling Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
Diseases associated with XIAP recombinant proteinOrgans/Tissues associated with XIAP recombinant protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >452 publications with XIAP and Necrosis
 Leukemia Antibodies  >383 publications with XIAP and Leukemia
 Adenocarcinoma Antibodies  >180 publications with XIAP and Adenocarcinoma
 Nervous System Diseases Antibodies  >163 publications with XIAP and Nervous System Diseases
 Breast Neoplasms Antibodies  >114 publications with XIAP and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >111 publications with XIAP and Neoplasms, Experimental
 Brain Diseases Antibodies  >111 publications with XIAP and Brain Diseases
 Liver Diseases Antibodies  >110 publications with XIAP and Liver Diseases
 Lung Neoplasms Antibodies  >100 publications with XIAP and Lung Neoplasms
 Liver Neoplasms Antibodies  >99 publications with XIAP and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >326 publications with XIAP and Blood
 Brain Antibodies  >176 publications with XIAP and Brain
 Liver Antibodies  >144 publications with XIAP and Liver
 Lung Antibodies  >138 publications with XIAP and Lung
 Prostate Antibodies  >119 publications with XIAP and Prostate
 Bone Antibodies  >96 publications with XIAP and Bone
 Vascular Antibodies  >83 publications with XIAP and Vascular
 Nerve Antibodies  >81 publications with XIAP and Nerve
 Muscle Antibodies  >72 publications with XIAP and Muscle
 Bone Marrow Antibodies  >60 publications with XIAP and Bone Marrow
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