View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List XIAP recombinant protein :: X-Linked Inhibitor Of Apoptosis Recombinant Protein Catalog # MBS2031583 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment) Unit / Price 0.01 mg / $180 +1 FREE 8GB USB 0.05 mg / $315 +1 FREE 8GB USB 0.1 mg / $470 +1 FREE 8GB USB 0.2 mg / $575 +1 FREE 8GB USB 0.5 mg / $1,075 +1 FREE 8GB USB 1 mg / $1,585 +1 FREE 8GB USB 5 mg / $3,855 +4 FREE 8GB USB 5x5 mg / $17,340 +10 FREE 8GB USB Previous Next Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name X-Linked Inhibitor Of Apoptosis (XIAP), Recombinant Protein Popular Item Full Product Name Recombinant X-Linked Inhibitor Of Apoptosis Protein (XIAP) Product Gene Name XIAP recombinant protein[Similar Products] Matching Pairs Unconjugated Antibody: XIAP (MBS2028046)Immunogen: XIAP (MBS2031583) Matching Pairs APC-CY7 Conjugated Antibody: XIAP (MBS2067043)Immunogen: XIAP (MBS2031583) Matching Pairs PE Conjugated Antibody: XIAP (MBS2067044)Immunogen: XIAP (MBS2031583) Show more Matching Pairs Matching Pairs APC Conjugated Antibody: XIAP (MBS2067045)Immunogen: XIAP (MBS2031583) Matching Pairs Cy3 Conjugated Antibody: XIAP (MBS2067046)Immunogen: XIAP (MBS2031583) Matching Pairs FITC Conjugated Antibody: XIAP (MBS2067047)Immunogen: XIAP (MBS2031583) Matching Pairs HRP Conjugated Antibody: XIAP (MBS2067048)Immunogen: XIAP (MBS2031583) Matching Pairs Biotin Conjugated Antibody: XIAP (MBS2094701)Immunogen: XIAP (MBS2031583) Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP MBS2031583 Technical Datasheet Technical Datasheet PDF OMIM 300079 Host E.coli Species Reactivity Homo sapiens (Human) Purity/Purification > 90% Form/Format 20mM Tris, 150mM NaCl, pH8.0, containing 0.01% skl, 5%Trehalose. Concentration Original Concentration: 150ug/mL (lot specific) Source Prokaryotic expression Residues Met1~Ser497 Tags N-terminal His Tag Subcellular Location Nucleus, Cytoplasm Traits Freeze-dried powder Predicted isoelectric point 6.2 Usage Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex. Preparation and Storage Storage:Avoid repeated freeze/thaw cycles.Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.Stability Test:The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. ISO Certification Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory. Supply Chain Verification Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire. Other Notes Small volumes of XIAP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Applications Tested/Suitable for XIAP recombinant protein Positive Control; Immunogen; SDS-PAGE; Western Blot (WB). Application Notes for XIAP recombinant protein (May be suitable for use in other assays to be determined by the end user.) Sequence of XIAP recombinant protein SDS-Page of XIAP recombinant protein TOP NCBI/Uniprot data below describe general gene information for XIAP. It may not necessarily be applicable to this product. NCBI GI # 21619764 NCBI GeneID 331 UniProt Secondary Accession # Q9NQ14; D3DTF2[Other Products] UniProt Related Accession # P98170[Other Products] Molecular Weight Predicted Molecular Mass: 60.4kDaAccurate Molecular Mass: 60kDa as determined by SDS-PAGE reducing conditions. TOP NCBI Official Full Name X-linked inhibitor of apoptosis NCBI Official Synonym Full Names X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase NCBI Official Symbol XIAP [Similar Products] NCBI Official Synonym Symbols API3; ILP1; MIHA; XLP2; BIRC4; IAP-3; hIAP3; hIAP-3 [Similar Products] NCBI Protein Information E3 ubiquitin-protein ligase XIAP UniProt Protein Name E3 ubiquitin-protein ligase XIAP UniProt Synonym Protein Names Baculoviral IAP repeat-containing protein 4; IAP-like protein; ILP; hILP; Inhibitor of apoptosis protein 3; IAP-3; hIAP-3; hIAP3; X-linked inhibitor of apoptosis protein; X-linked IAP Protein Family E3 ubiquitin-protein ligase UniProt Gene Name XIAP [Similar Products] UniProt Synonym Gene Names API3; BIRC4; IAP3; ILP; hILP; IAP-3; hIAP-3; hIAP3; X-linked IAP [Similar Products] UniProt Entry Name XIAP_HUMAN TOP NCBI Summary for XIAP This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011] TOP UniProt Comments for XIAP XIAP: an apoptotic suppressor protein. Inhibist apoptosis through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2. Inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. Inhibits cell-death proteases, caspase-3, caspase-7, and perhaps caspase-9.Protein type: Ubiquitin conjugating system; Ligase; EC 6.3.2.-; Ubiquitin ligase; ApoptosisChromosomal Location of Human Ortholog: Xq25Cellular Component: nucleoplasm; spindle microtubule; cytoplasm; cytosol; nucleusMolecular Function: protein binding; zinc ion binding; caspase inhibitor activity; ubiquitin-protein ligase activity; ligase activityBiological Process: Wnt receptor signaling pathway; apoptosis; positive regulation of protein ubiquitination; regulation of BMP signaling pathway; regulation of inflammatory response; protein ubiquitination; negative regulation of caspase activity; response to DNA damage stimulus; copper ion homeostasis; regulation of cell proliferation; negative regulation of apoptosis; regulation of innate immune responseDisease: Lymphoproliferative Syndrome, X-linked, 1; Lymphoproliferative Syndrome, X-linked, 2 Research Articles on XIAP 1. Patients carrying the Glu349del mutation in the XIAP gene may have a clinically and immunologically distinct phenotype from patients with other XIAP mutations. The Glu349del mutation may be associated with dysgammaglobulinemia. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with XIAP recombinant protein Reference Product PubMed Publications CASP3 recombinant protein >893 publications with XIAP and CASP3 CASP9 recombinant protein >431 publications with XIAP and CASP9 DIABLO recombinant protein >317 publications with XIAP and DIABLO CASP7 recombinant protein >82 publications with XIAP and CASP7 HTRA2 recombinant protein >79 publications with XIAP and HTRA2 APAF1 recombinant protein >61 publications with XIAP and APAF1 TAB1 recombinant protein >12 publications with XIAP and TAB1 UBC recombinant protein >3 publications with XIAP and UBC UBE2D1 recombinant protein >1 publications with XIAP and UBE2D1 Pathways associated with XIAP recombinant protein Products by Pathway Pathway Diagram Apoptosis Pathway antibodies Apoptosis Pathway Diagram Apoptosis Pathway antibodies Apoptosis Pathway Diagram Apoptosis Pathway antibodies Apoptosis Pathway Diagram Apoptosis Pathway antibodies Apoptosis Pathway Diagram Apoptotic Factor-mediated Response Pathway antibodies Apoptotic Factor-mediated Response Pathway Diagram BMP Receptor Signaling Pathway antibodies BMP Receptor Signaling Pathway Diagram Caspase Cascade In Apoptosis Pathway antibodies Caspase Cascade In Apoptosis Pathway Diagram Focal Adhesion Pathway antibodies Focal Adhesion Pathway Diagram Focal Adhesion Pathway antibodies Focal Adhesion Pathway Diagram HTLV-I Infection Pathway antibodies HTLV-I Infection Pathway Diagram Diseases associated with XIAP recombinant protein Disease Name Pubmed Publications Necrosis Antibodies >452 publications with XIAP and Necrosis Leukemia Antibodies >383 publications with XIAP and Leukemia Adenocarcinoma Antibodies >180 publications with XIAP and Adenocarcinoma Nervous System Diseases Antibodies >163 publications with XIAP and Nervous System Diseases Breast Neoplasms Antibodies >114 publications with XIAP and Breast Neoplasms Neoplasms, Experimental Antibodies >111 publications with XIAP and Neoplasms, Experimental Brain Diseases Antibodies >111 publications with XIAP and Brain Diseases Liver Diseases Antibodies >110 publications with XIAP and Liver Diseases Lung Neoplasms Antibodies >100 publications with XIAP and Lung Neoplasms Liver Neoplasms Antibodies >99 publications with XIAP and Liver Neoplasms Organs/Tissues associated with XIAP recombinant protein Organ/Tissue Name Pubmed Publications Blood Antibodies >326 publications with XIAP and Blood Brain Antibodies >176 publications with XIAP and Brain Liver Antibodies >144 publications with XIAP and Liver Lung Antibodies >138 publications with XIAP and Lung Prostate Antibodies >119 publications with XIAP and Prostate Bone Antibodies >96 publications with XIAP and Bone Vascular Antibodies >83 publications with XIAP and Vascular Nerve Antibodies >81 publications with XIAP and Nerve Muscle Antibodies >72 publications with XIAP and Muscle Bone Marrow Antibodies >60 publications with XIAP and Bone Marrow TOP