NP_620780.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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NCBI Official Full Name
thyroid autoantigen
NCBI Official Synonym Full Names
X-ray repair complementing defective repair in Chinese hamster cells 6
NCBI Protein Information
thyroid autoantigen; Ku70 DNA-binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa)
UniProt Protein Name
Protein Xrcc6
UniProt Entry Name
Q6AZ64_RAT
NCBI Summary for XRCC6
DNA targeting component of the DNA-dependent protein kinase complex DNA-PK, which plays a role in DNA double strand break repair [RGD, Feb 2006]
UniProt Comments for XRCC6
Ku70: a mini-chromosome maintenance protein, essential for the initiation of eukaryotic genome replication. Allows DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division.
Protein type: Helicase; Nuclear receptor co-regulator; EC 4.2.99.-; RNA-binding; EC 3.6.4.-; DNA repair, damage; DNA-binding
Cellular Component: nucleoplasm; transcription factor complex; protein complex; membrane; cytoplasm; nucleolus; nucleus
Molecular Function: ATP-dependent DNA helicase activity; protein C-terminus binding; protein binding; double-stranded DNA binding; damaged DNA binding; telomeric DNA binding; double-stranded telomeric DNA binding; 5'-deoxyribose-5-phosphate lyase activity
Biological Process: positive regulation of neurogenesis; V(D)J recombination; double-strand break repair; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; brain development; response to ionizing radiation; negative regulation of transcription, DNA-dependent; telomere maintenance; response to DNA damage stimulus; DNA duplex unwinding; double-strand break repair via nonhomologous end joining
Research Articles on XRCC6
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Products associated with XRCC6 recombinant protein
Pathways associated with XRCC6 recombinant protein
Diseases associated with XRCC6 recombinant protein
Organs/Tissues associated with XRCC6 recombinant protein
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