NP_001258659.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,888 Da
NCBI Official Full Name
X-box-binding protein 1 isoform XBP1(S)
NCBI Official Synonym Full Names
X-box binding protein 1
NCBI Official Synonym Symbols
TREB5; XBP-1; TREB-5; D11Ertd39e [Similar Products]
NCBI Protein Information
X-box-binding protein 1
UniProt Protein Name
X-box-binding protein 1
UniProt Synonym Protein Names
Tax-responsive element-binding protein 5
UniProt Synonym Gene Names
UniProt Comments for Xbp1
Functions as a transcription factor during endoplasmic reticulum stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development and the development of secretory tissues such as exocrine pancreas and salivary gland (PubMed:10425189, PubMed:10652269, PubMed:16362047, PubMed:17612490). Involved in differentiation of B lymphocytes to plasma cells and production of immunoglobulins. Modulates the cellular response to ER stress in a PIK3R-dependent manner. Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions (PubMed:23529610). Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention (PubMed:15486293).
Research Articles on Xbp1
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Products associated with Xbp1 recombinant protein
Pathways associated with Xbp1 recombinant protein
Diseases associated with Xbp1 recombinant protein
Organs/Tissues associated with Xbp1 recombinant protein
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