Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow XRCC6/G22P1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • HIV-1 gag p24 Recombinant Protein
 • Insulin-like growth factor 1 (IGF-1) ELISA Kit
 • H Cadherin (CDH13) Antibody
 • CaMKIbeta Antibody
 • Akt (Akt1) Antibody
 • GFP Antibody
 • growth differentiation factor 11 (GDF11) ELISA Kit
 • G-CSF Antibody
 • ACTH Antibody
 • beta tubulin (TUBB) ELISA Kit
 • iron-responsive element binding protein 2 (IREB2) ELISA Kit
 • Angiotensin II (AngII) ELISA Kit
 • Elastin (ELN) ELISA Kit
 • sIgA ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

XRCC6/G22P1 recombinant protein :: X-ray repair cross-complementing protein 6 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1265152
SDS-PAGE
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.05 mg  /  $190 +1 FREE 8GB USB
0.1 mg  /  $285 +1 FREE 8GB USB
0.2 mg  /  $460 +1 FREE 8GB USB
0.5 mg  /  $750 +1 FREE 8GB USB
1 mg  /  $1,180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

X-ray repair cross-complementing protein 6 (XRCC6/G22P1), Recombinant Protein

 Also Known As   

Recombinant Human X-ray repair cross-complementing protein 6

 Product Synonym Names    5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; Lupus Ku autoantigen protein p70; Ku70; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 6
 Product Gene Name   

XRCC6/G22P1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence Positions    6-222aa; Partial
 Sequence    SYYKTEGDEE AEEEQEENLE ASGDYKYSGR DSLIFLVDAS KAMFESQSED ELTPFDMSIQ CIQSVYISKI ISSDRDLLAV VFYGTEKDKN SVNFKNIYVL QELDNPGAKR ILELDQFKGQ QGQKRFQDMM GHGSDYSLSE VLWVCANLFS DVQFKMSHKR IMLFTNEDNP HGNDSAKASR ARTKAGDLRD TGIFLDLMHL KKPGGFDISL FYRDIIS
 OMIM    152690
 3D Structure    ModBase 3D Structure for P12956
Section Bar
 Host    E Coli
Section Bar
 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
Section Bar
Section Bar
 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of XRCC6/G22P1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for XRCC6/G22P1 recombinant protein

   Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing th together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription
 Product Categories/Family for XRCC6/G22P1 recombinant protein    Epigenetics and Nuclear Signaling
Section Bar
 SDS-PAGE of XRCC6/G22P1 recombinant protein    XRCC6/G22P1 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for XRCC6/G22P1. It may not necessarily be applicable to this product.
 NCBI GI #    573014815
 NCBI GeneID    2547
 NCBI Accession #    NP_001275905.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001288976.1 [Other Products]
Section Bar
 UniProt Primary Accession #    P12956 [Other Products]
 UniProt Secondary Accession #    Q6FG89; Q9UCQ2; Q9UCQ3; B1AHC8 [Other Products]
 UniProt Related Accession #    P12956 [Other Products]
 Molecular Weight    28.9kD
Table BarTOPTable Bar
 NCBI Official Full Name    X-ray repair cross-complementing protein 6 isoform 1
 NCBI Official Synonym Full Names    X-ray repair complementing defective repair in Chinese hamster cells 6
 NCBI Official Symbol    XRCC6 [Similar Products]
 NCBI Official Synonym Symbols   
ML8; KU70; TLAA; CTC75; CTCBF; G22P1
[Similar Products]
 NCBI Protein Information    X-ray repair cross-complementing protein 6
 UniProt Protein Name    X-ray repair cross-complementing protein 6
 UniProt Synonym Protein Names   
5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; Lupus Ku autoantigen protein p70; Ku70; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 6
 Protein Family    X-ray repair cross-complementing protein
 UniProt Gene Name    XRCC6 [Similar Products]
 UniProt Synonym Gene Names    G22P1; 5'-dRP lyase Ku70; CTC75; CTCBF; Ku70; TLAA [Similar Products]
 UniProt Entry Name    XRCC6_HUMAN
Section Bar
 NCBI Summary for XRCC6/G22P1    The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for XRCC6/G22P1    Ku70: a mini-chromosome maintenance protein, essential for the initiation of eukaryotic genome replication. Allows DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division.

Protein type: Nuclear receptor co-regulator; Helicase; EC 3.6.4.-; DNA-binding; EC 4.2.99.-; RNA-binding; DNA repair, damage

Chromosomal Location of Human Ortholog: 22q13.2

Cellular Component: cytosol; membrane; nuclear chromosome, telomeric region; nuclear telomere cap complex; nucleoplasm; nucleus; transcription factor complex

Molecular Function: 5'-deoxyribose-5-phosphate lyase activity; ATP binding; ATP-dependent DNA helicase activity; damaged DNA binding; DNA binding; double-stranded DNA binding; double-stranded telomeric DNA binding; protein binding; protein C-terminus binding

Biological Process: DNA duplex unwinding; DNA ligation; DNA recombination; DNA repair; double-strand break repair; double-strand break repair via nonhomologous end joining; innate immune response; negative regulation of transcription, DNA-dependent; positive regulation of interferon type I production; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein heterotetramerization; regulation of smooth muscle cell proliferation; telomere maintenance; transcription, DNA-dependent; viral reproduction
Table BarTOPTable Bar
 

Product References and Citations for XRCC6/G22P1 recombinant protein

   Cloning and characterization of a cDNA that encodes a 70-kDa novel human thyroid autoantigen.Chan J.Y., Lerman M.I., Prabhakar B.S., Isozaki O., Santisteban P., Kuppers R.C., Oates E.L., Notkins A.L., Kohn L.D.J. Biol. Chem. 264:3651-3654(1989)
Section Bar
 Research Articles on XRCC6/G22P1    1. retinoblastoma tumor suppressor protein variants disabled for the interaction with XRCC5 and XRCC6, including a cancer-associated variant, are unable to support canonical non-homologous end-joining despite being able to confer cell-cycle control
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with XRCC6/G22P1 recombinant proteinPathways associated with XRCC6/G22P1 recombinant protein
 Reference Product  PubMed Publications
 LIG4 recombinant protein  >7 publications with XRCC6/G22P1 and LIG4
 PRKDC recombinant protein  >6 publications with XRCC6/G22P1 and PRKDC
 MRE11A recombinant protein  >3 publications with XRCC6/G22P1 and MRE11A
 BAX recombinant protein  >2 publications with XRCC6/G22P1 and BAX
 SIRT1 recombinant protein  >1 publications with XRCC6/G22P1 and SIRT1
 WRN recombinant protein  >1 publications with XRCC6/G22P1 and WRN
 Products by Pathway  Pathway Diagram
 2-LTR Circle Formation Pathway antibodies  2-LTR Circle Formation Pathway Diagram
 BARD1 Signaling Events Pathway antibodies  BARD1 Signaling Events Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 DNA Double-Strand Break Repair Pathway antibodies  DNA Double-Strand Break Repair Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 DNA-PK Complex Pathway antibodies  DNA-PK Complex Pathway Diagram
 DNA-PK Complex Pathway antibodies  DNA-PK Complex Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Early Phase Of HIV Life Cycle Pathway antibodies  Early Phase Of HIV Life Cycle Pathway Diagram
Diseases associated with XRCC6/G22P1 recombinant proteinOrgans/Tissues associated with XRCC6/G22P1 recombinant protein
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >15 publications with XRCC6/G22P1 and Carcinoma
 Adenocarcinoma Antibodies  >9 publications with XRCC6/G22P1 and Adenocarcinoma
 Breast Neoplasms Antibodies  >8 publications with XRCC6/G22P1 and Breast Neoplasms
 Carcinoma, Hepatocellular Antibodies  >5 publications with XRCC6/G22P1 and Carcinoma, Hepatocellular
 Chromosome Aberrations Antibodies  >5 publications with XRCC6/G22P1 and Chromosome Aberrations
 Liver Neoplasms Antibodies  >4 publications with XRCC6/G22P1 and Liver Neoplasms
 Leukemia Antibodies  >4 publications with XRCC6/G22P1 and Leukemia
 Lymphoma Antibodies  >4 publications with XRCC6/G22P1 and Lymphoma
 Liver Diseases Antibodies  >4 publications with XRCC6/G22P1 and Liver Diseases
 Lung Neoplasms Antibodies  >3 publications with XRCC6/G22P1 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >12 publications with XRCC6/G22P1 and Blood
 Liver Antibodies  >5 publications with XRCC6/G22P1 and Liver
 Lung Antibodies  >5 publications with XRCC6/G22P1 and Lung
 Brain Antibodies  >4 publications with XRCC6/G22P1 and Brain
 Kidney Antibodies  >3 publications with XRCC6/G22P1 and Kidney
 Ovary Antibodies  >3 publications with XRCC6/G22P1 and Ovary
 Prostate Antibodies  >3 publications with XRCC6/G22P1 and Prostate
 Bone Antibodies  >2 publications with XRCC6/G22P1 and Bone
 Bladder Antibodies  >2 publications with XRCC6/G22P1 and Bladder
 Bone Marrow Antibodies  >2 publications with XRCC6/G22P1 and Bone Marrow
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions