NP_001161076.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
85.8 kDa
NCBI Official Full Name
xaa-Pro aminopeptidase 1 isoform 2
NCBI Official Synonym Full Names
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
NCBI Official Synonym Symbols
APP1; SAMP; XPNPEP; XPNPEPL; XPNPEPL1 [Similar Products]
NCBI Protein Information
xaa-Pro aminopeptidase 1
UniProt Protein Name
Xaa-Pro aminopeptidase 1
UniProt Synonym Protein Names
Aminoacylproline aminopeptidase; Cytosolic aminopeptidase P; Soluble aminopeptidase P; sAmp; X-Pro aminopeptidase 1; X-prolyl aminopeptidase 1, soluble
UniProt Synonym Gene Names
UniProt Entry Name
XPP1_HUMAN
NCBI Summary for XPNPEP1
This gene encodes the cytosolic form of a metalloaminopeptidase that catalyzes the cleavage of the N-terminal amino acid adjacent to a proline residue. The gene product may play a role in degradation and maturation of tachykinins, neuropeptides, and peptide hormones. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]
UniProt Comments for XPNPEP1
XPNPEP1: Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. Belongs to the peptidase M24B family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.11.9; Protease
Chromosomal Location of Human Ortholog: 10q25.3
Cellular Component: cytoplasm
Molecular Function: aminopeptidase activity; manganese ion binding; protein homodimerization activity
Biological Process: proteolysis
Research Articles on XPNPEP1
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Diseases associated with XPNPEP1 recombinant protein
Organs/Tissues associated with XPNPEP1 recombinant protein
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