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XDH recombinant protein :: Xanthine dehydrogenase/oxidase (XDH), partial Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS958091
Testing Data
Unit / Price
0.05 mg (E-Coli)  /  $495 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $655 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $665 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $725 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $820 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $895 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,005 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,015 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,030 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,055 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,500 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,530 +1 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,615 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,010 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Xanthine dehydrogenase/oxidase (XDH), partial, Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Xanthine dehydrogenase/oxidase (XDH), partial

 Product Synonym Names    Xanthine dehydrogenase/oxidase; Including the following 2 domains:; Xanthine dehydrogenase; XD; EC=1.17.1.4; Xanthine oxidase; XO; EC=1.17.3.2; Xanthine oxidoreductase
 Product Gene Name   

XDH recombinant protein

[Similar Products]
 Product Synonym Gene Name    XDH; XDHA [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS958091 COA    COA PDF
 Sequence Positions    1234-1333. Partial.
 Sequence    GSIPIEFRVS LLRDCPNKKA IYASKAVGEP PLFLAASIFF AIKDAIRAAR AQHTGNNVKE LFRLDSPATP EKIRNACVDK FTTLCVTGVP ENCKPWSVRV
 OMIM    607633
 3D Structure    ModBase 3D Structure for P47989
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of XDH recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for XDH recombinant protein

   XDH; XDHA
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 Testing Data of XDH recombinant protein    XDH recombinant protein Testing Data image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for XDH. It may not necessarily be applicable to this product.
 NCBI GI #    91823271
 NCBI GeneID    7498
 NCBI Accession #    NP_000370.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000379.3 [Other Products]
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 UniProt Primary Accession #    P47989 [Other Products]
 UniProt Secondary Accession #    Q16681; Q16712; Q4PJ16 [Other Products]
 UniProt Related Accession #    P47989 [Other Products]
 Molecular Weight    146,424 Da
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 NCBI Official Full Name    xanthine dehydrogenase/oxidase
 NCBI Official Synonym Full Names    xanthine dehydrogenase
 NCBI Official Symbol    XDH [Similar Products]
 NCBI Official Synonym Symbols   
XO; XOR
[Similar Products]
 NCBI Protein Information    xanthine dehydrogenase/oxidase; xanthine oxidoreductase
 UniProt Protein Name    Xanthine dehydrogenase/oxidase
 UniProt Synonym Protein Names   
Xanthine oxidoreductase; XOR
 Protein Family    Xanthine dehydrogenase
 UniProt Gene Name    XDH [Similar Products]
 UniProt Synonym Gene Names    XDHA; XD; XO; XOR [Similar Products]
 UniProt Entry Name    XDH_HUMAN
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 NCBI Summary for XDH    Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. [provided by RefSeq, Jan 2014]
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 UniProt Comments for XDH    XDH: Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro). Defects in XDH are the cause of xanthinuria type 1 (XU1). Xanthinuria is characterized by excretion of very large amounts of xanthine in the urine and a tendency to form xanthine stones. Uric acid is strikingly diminished in serum and urine. XU1 is due to isolated xanthine dehydrogenase. XU1 patients can metabolize allopurinol. Belongs to the xanthine dehydrogenase family.

Protein type: Oxidoreductase; EC 1.17.1.4; Xenobiotic Metabolism - drug metabolism - other enzymes; EC 1.17.3.2; Secondary Metabolites Metabolism - caffeine; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 2p23.1

Cellular Component: extracellular space; peroxisome; cytosol

Molecular Function: molybdopterin cofactor binding; 2 iron, 2 sulfur cluster binding; UDP-N-acetylmuramate dehydrogenase activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors; protein homodimerization activity; electron carrier activity; FAD binding; iron ion binding; xanthine dehydrogenase activity; xanthine oxidase activity

Biological Process: lactation; caspase activation; xanthine catabolic process; negative regulation of protein kinase B signaling cascade; negative regulation of protein amino acid phosphorylation; negative regulation of endothelial cell differentiation; nucleobase, nucleoside and nucleotide metabolic process; negative regulation of endothelial cell proliferation; purine nucleotide catabolic process; purine base metabolic process

Disease: Xanthinuria, Type I
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 Research Articles on XDH    1. This study reveals a noncanonical molecular pathway in which, after the inhibition of cathepsin S, autophagy induces early reactive oxygen species production for oxidative DNA damage and cell death through xanthine oxidase.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with XDH recombinant proteinPathways associated with XDH recombinant protein
 Reference Product  PubMed Publications
 BTN1A1 recombinant protein  >1 publications with XDH and BTN1A1
 Products by Pathway  Pathway Diagram
 Caffeine Metabolism Pathway antibodies  Caffeine Metabolism Pathway Diagram
 Caffeine Metabolism Pathway antibodies  Caffeine Metabolism Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Oxidative Stress Pathway antibodies  Oxidative Stress Pathway Diagram
 Peroxisome Pathway antibodies  Peroxisome Pathway Diagram
 Peroxisome Pathway antibodies  Peroxisome Pathway Diagram
 Purine Catabolism Pathway antibodies  Purine Catabolism Pathway Diagram
Diseases associated with XDH recombinant proteinOrgans/Tissues associated with XDH recombinant protein
 Disease Name  Pubmed Publications
 Ischemia Antibodies  >31 publications with XDH and Ischemia
 Reperfusion Injury Antibodies  >26 publications with XDH and Reperfusion Injury
 Cardiovascular Diseases Antibodies  >23 publications with XDH and Cardiovascular Diseases
 Metabolic Diseases Antibodies  >17 publications with XDH and Metabolic Diseases
 Female Urogenital Diseases Antibodies  >13 publications with XDH and Female Urogenital Diseases
 Male Urogenital Diseases Antibodies  >13 publications with XDH and Male Urogenital Diseases
 Genetic Diseases, Inborn Antibodies  >12 publications with XDH and Genetic Diseases, Inborn
 Lung Injury Antibodies  >12 publications with XDH and Lung Injury
 Neoplasms Antibodies  >12 publications with XDH and Neoplasms
 Kidney Diseases Antibodies  >12 publications with XDH and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >74 publications with XDH and Liver
 Kidney Antibodies  >27 publications with XDH and Kidney
 Lung Antibodies  >20 publications with XDH and Lung
 Intestine Antibodies  >14 publications with XDH and Intestine
 Muscle Antibodies  >13 publications with XDH and Muscle
 Eye Antibodies  >10 publications with XDH and Eye
 Mammary Gland Antibodies  >4 publications with XDH and Mammary Gland
 Embryonic Tissue Antibodies  >4 publications with XDH and Embryonic Tissue
 Mouth Antibodies  >2 publications with XDH and Mouth
 Pancreas Antibodies  >2 publications with XDH and Pancreas
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