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YARS2 recombinant protein

Scan QR to view Datasheet Catalog #    MBS204733
SDS-Page
Unit / Price
0.02 mg  /  $310 +1 FREE 8GB USB
0.1 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

YARS2, Recombinant Protein

 Also Known As   

YARS2, 17-477aa, Human, His tag, E Coli

 Product Synonym Names    Tyrosyl-tRNA synthetase mitochondrial precursor; Tyrosyl-tRNA synthetase; mitochondrial precursor; CGI-04; FLJ13995; MLASA2; MT-TYRRS; TYRRS
 Product Gene Name   

YARS2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MTLNLSVLLP LGLRKAHSGA QGLLAAQKAR GLFKDFFPET GTKIELPELF DRGTASFPQT IYCGFDPTAD SLHVGHLLAL LGLFHLQRAG HNVIALVGGA TARLGDPSGR TKEREALETE RVRANARALR LGLEALAANH QQLFTDGRSW GSFTVLDNSA WYQKQHLVDF LAAVGGHFRM GTLLSRQSVQ LRLKSPEGMS LAEFFYQVLQ AYDFYYLFQR YGCRVQLGGS DQLGNIMSGY EFINKLTGED VFGITVPLIT STTGAKLGKS AGNAVWLNRD KTSPFELYQF FVRQPDDSVE RYLKLFTFLP LPEIDHIMQL HVKEPERRGP QKRLAAEVTK LVHGREGLDS AKRCTQALYH SSIDALEVMS DQELKELFKE APFSEFFLDP GTSVLDTCRK ANAIPDGPRG YRMITEGGVS INHQQVTNPE SVLIVGQHIL KNGLSLLKIG KRNFYIIKWL QL
 OMIM    AF132939 mRNA
 3D Structure    ModBase 3D Structure for Q9Y2Z4
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 Host    E Coli
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 Purity/Purification    > 85% by SDS-PAGE
 Form/Format    Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT
 Concentration    0.25 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of YARS2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for YARS2 recombinant protein

   YARS2, also known as tyrosyl-tRNA synthetase, catalyzes the attachment of tyrosine to tRNA (Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA (Tyr). Recombinant human YARS2 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography.
 Product Categories/Family for YARS2 recombinant protein    Enzymes & Proteases
 Applications Tested/Suitable for YARS2 recombinant protein   

SDS-PAGE

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 SDS-Page of YARS2 recombinant protein    YARS2 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for YARS2. It may not necessarily be applicable to this product.
 NCBI GI #    94681057
 NCBI GeneID    51067
 NCBI Accession #    NP_001035526 [Other Products]
 NCBI GenBank Nucleotide #    NM_001040436.2 [Other Products]
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 UniProt Primary Accession #    Q9Y2Z4 [Other Products]
 UniProt Secondary Accession #    Q9H817; D3DUW8 [Other Products]
 UniProt Related Accession #    Q9Y2Z4 [Other Products]
 Molecular Weight    53.7 kDa (482aa)
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 NCBI Official Full Name    tyrosine--tRNA ligase, mitochondrial
 NCBI Official Synonym Full Names    tyrosyl-tRNA synthetase 2
 NCBI Official Symbol    YARS2 [Similar Products]
 NCBI Official Synonym Symbols   
TYRRS; CGI-04; MLASA2; MT-TYRRS
[Similar Products]
 NCBI Protein Information    tyrosine--tRNA ligase, mitochondrial
 UniProt Protein Name    Tyrosine--tRNA ligase, mitochondrial
 UniProt Synonym Protein Names   
Tyrosyl-tRNA synthetase; TyrRS
 UniProt Gene Name    YARS2 [Similar Products]
 UniProt Synonym Gene Names    TyrRS [Similar Products]
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 NCBI Summary for YARS2    This gene encodes a mitochondrial protein that catalyzes the attachment of tyrosine to tRNA(Tyr). Mutations in this gene are associated with myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2). [provided by RefSeq, Jan 2011]
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 UniProt Comments for YARS2    Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
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Product References and Citations for YARS2 recombinant protein

   Bonnefond L., et al. (2005) Biochemistry. 44:4805-4816; Riley L.G., et al. (2010) Am. J. Hum. Genet. 87:52-59
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 Research Articles on YARS2    1. The p.Leu392Ser variant is likely a newly identified founder YARS2 mutation in mitochondrial myopathy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with YARS2 recombinant proteinPathways associated with YARS2 recombinant protein
 Reference Product  PubMed Publications
 PUS1 recombinant protein  >4 publications with YARS2 and PUS1
 Products by Pathway  Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies  Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
 Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies  Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Mitochondrial TRNA Aminoacylation Pathway antibodies  Mitochondrial TRNA Aminoacylation Pathway Diagram
 TRNA Aminoacylation Pathway antibodies  TRNA Aminoacylation Pathway Diagram
Diseases associated with YARS2 recombinant proteinOrgans/Tissues associated with YARS2 recombinant protein
 Disease Name  Pubmed Publications
 Anemia Antibodies  >10 publications with YARS2 and Anemia
 Atrophy Antibodies  >1 publications with YARS2 and Atrophy
 Heart Diseases Antibodies  >1 publications with YARS2 and Heart Diseases
 Cardiovascular Diseases Antibodies  >1 publications with YARS2 and Cardiovascular Diseases
 Myopathy with lactic acidosis and sideroblastic anemia Antibodies  >1 publications with YARS2 and Myopathy with lactic acidosis and sideroblastic anemia
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >2 publications with YARS2 and Bone
 Bone Marrow Antibodies  >2 publications with YARS2 and Bone Marrow
 Blood Antibodies  >2 publications with YARS2 and Blood
 Eye Antibodies  >1 publications with YARS2 and Eye
 Testis Antibodies  >1 publications with YARS2 and Testis
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