AKI72472.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Predicted Molecular Mass: 71.9kDa Accurate Molecular Mass: 72kDa as determined by SDS-PAGE reducing conditions.
NCBI Official Full Name
PROZ, partial
NCBI Official Synonym Full Names
protein Z, vitamin K-dependent plasma glycoprotein
NCBI Official Synonym Symbols
NCBI Protein Information
vitamin K-dependent protein Z
UniProt Protein Name
Vitamin K-dependent protein Z
UniProt Entry Name
PROZ_HUMAN
NCBI Summary for PROZ
This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
UniProt Comments for PROZ
PROZ: Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 13q34
Cellular Component: endoplasmic reticulum lumen; Golgi lumen
Molecular Function: serine-type endopeptidase activity; calcium ion binding
Biological Process: cellular protein metabolic process; blood coagulation; proteolysis; post-translational protein modification; peptidyl-glutamic acid carboxylation
Disease: Protein Z Deficiency
Research Articles on PROZ
Precautions
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Products associated with PROZ recombinant protein
Pathways associated with PROZ recombinant protein
Diseases associated with PROZ recombinant protein
Organs/Tissues associated with PROZ recombinant protein
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