NP_001126104.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
52,580 Da
NCBI Official Full Name
BUB3-interacting and GLEBS motif-containing protein ZNF207
NCBI Official Synonym Symbols
NCBI Protein Information
BUB3-interacting and GLEBS motif-containing protein ZNF207
UniProt Protein Name
BUB3-interacting and GLEBS motif-containing protein ZNF207
UniProt Synonym Protein Names
Zinc finger protein 207
UniProt Synonym Gene Names
UniProt Comments for ZNF207
Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks. Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3. According to another report, the stabilization is independent of the proteasome.
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Products associated with ZNF207 recombinant protein
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